High level of conservation in Plasmodium vivax merozoite surface protein 4 (PvMSP4)

Pilar Martinez, Carlos F. Suarez, Andromeda Gomez, Paula P. Cardenas, Jose E. Guerrero, Manuel A. Patarroyo

Resultado de la investigación: Contribución a una revistaArtículo

16 Citas (Scopus)

Resumen

Plasmodium vivaxmerozoite surface protein 4 (PvMSP4) has been considered to be a promising malarial vaccine candidate. The antigenicdiversity displayed by parasite populations is one of the main factors limiting the efficacy of asexual-stage anti-malarial vaccine candidates.The present study is the first characterising PvMSP4 polymorphism.P. vivaxisolates were collected from endemic areas in Colombia anddiversity and selection pattern studies were carried out. Overall conservation in this protein was remarkable. Changes were only found inexons I and II, the former only having single nucleotide polymorphisms (SNPs) whilst the latter showed variations in tandem repeat numbercaused by exon II slippage. The remaining regions (EGF-like domain, GPI anchor and intron) were completely conserved. Selection andneutrality tests carried out over variant exons indicated negative selective forces acting on them. No evidence of intragenic recombination wasfound. The strong conservation displayed in this molecule by isolates from geographically different regions (Colombia, Salvador andThailand) stresses its potential importance as a candidate for a vaccine againstP. vivaxmalaria.#2004 Elsevier B.V. All rights reserved.
Idioma originalInglés estadounidense
Páginas (desde-hasta)354-361
Número de páginas8
PublicaciónInfection, Genetics and Evolution
Volumen5
N.º4
DOI
EstadoPublicada - ene 18 2005
Publicado de forma externa

All Science Journal Classification (ASJC) codes

  • Microbiología
  • Ecología, evolución, comportamiento y sistemática
  • Biología molecular
  • Genética
  • Microbiología (médica)
  • Enfermedades infecciosas

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