High frequency of toxigenic Clostridium difficile and Clostridium perfringens coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogotá, Colombia

Alex J. Forero; Marina Muñoz; Milena Camargo; Sara C. Soto-De León; Dora I. Ríos-Chaparro; Claudia Birchenall; Darío Pinilla; Juan Mauricio Pardo Oviedo; Diego F. Josa; Manuel A. Patarroyo; Juan D. Ramírez

doi:10.1186/s13099-019-0308-7

High frequency of toxigenic Clostridium difficile and Clostridium perfringens coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogotá, Colombia

Alex J. Forero, Marina Muñoz, Milena Camargo, Sara C. Soto-De León, Dora I. Ríos-Chaparro, Claudia Birchenall, Darío Pinilla, Juan Mauricio Pardo Oviedo, Diego F. Josa, Manuel A. Patarroyo, Juan D. Ramírez

Producción científica: Contribución a una revista › Artículo de Investigación › revisión exhaustiva

5 Citas (Scopus)

Resumen

Background: The aim of this study was to evaluate the frequency of toxigenic C. difficile and C. perfringens infections at health care facility-onset (HCFO) and community-onset (CO), in two health care centers (HCC) in Bogotá, Colombia. A total of 220 stool samples from patients presenting diarrhea acquired at HCFO or CO were analyzed by several PCR tests. Results: We found that 65.5% (n = 144) of the population had C. difficile infection, followed by toxigenic C. difficile with 57.3% (n = 126), and finally toxigenic C. perfringens with a frequency of 32.7% (n = 72). Conclusions: This study is the first molecular detection and characterization of C. difficile and C. perfringens in HCFO and CO in Latin America and demonstrates a relevant frequency of these two species, including coinfection and strikingly diverse toxigenic profiles, especially in the CO.

Idioma original	Inglés estadounidense
Número de artículo	27
Publicación	Gut Pathogens
Volumen	11
N.º	1
DOI	https://doi.org/10.1186/s13099-019-0308-7
Estado	Publicada - jun. 3 2019

Áreas temáticas de ASJC Scopus

Parasitología
Microbiología
Gastroenterología
Virología
Enfermedades infecciosas

ODS de las Naciones Unidas

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Forero, A. J., Muñoz, M., Camargo, M., Soto-De León, S. C., Ríos-Chaparro, D. I., Birchenall, C., Pinilla, D., Pardo Oviedo, J. M., Josa, D. F., Patarroyo, M. A., & Ramírez, J. D. (2019). High frequency of toxigenic Clostridium difficile and Clostridium perfringens coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogotá, Colombia. Gut Pathogens, 11(1), Artículo 27. https://doi.org/10.1186/s13099-019-0308-7

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title = "High frequency of toxigenic Clostridium difficile and Clostridium perfringens coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogot{\'a}, Colombia",

abstract = "Background: The aim of this study was to evaluate the frequency of toxigenic C. difficile and C. perfringens infections at health care facility-onset (HCFO) and community-onset (CO), in two health care centers (HCC) in Bogot{\'a}, Colombia. A total of 220 stool samples from patients presenting diarrhea acquired at HCFO or CO were analyzed by several PCR tests. Results: We found that 65.5% (n = 144) of the population had C. difficile infection, followed by toxigenic C. difficile with 57.3% (n = 126), and finally toxigenic C. perfringens with a frequency of 32.7% (n = 72). Conclusions: This study is the first molecular detection and characterization of C. difficile and C. perfringens in HCFO and CO in Latin America and demonstrates a relevant frequency of these two species, including coinfection and strikingly diverse toxigenic profiles, especially in the CO.",

author = "Forero, {Alex J.} and Marina Mu{\~n}oz and Milena Camargo and {Soto-De Le{\'o}n}, {Sara C.} and R{\'i}os-Chaparro, {Dora I.} and Claudia Birchenall and Dar{\'i}o Pinilla and {Pardo Oviedo}, {Juan Mauricio} and Josa, {Diego F.} and Patarroyo, {Manuel A.} and Ram{\'i}rez, {Juan D.}",

year = "2019",

month = jun,

day = "3",

doi = "10.1186/s13099-019-0308-7",

language = "English (US)",

volume = "11",

journal = "Gut Pathogens",

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Forero, AJ, Muñoz, M, Camargo, M, Soto-De León, SC, Ríos-Chaparro, DI, Birchenall, C, Pinilla, D, Pardo Oviedo, JM, Josa, DF, Patarroyo, MA & Ramírez, JD 2019, 'High frequency of toxigenic Clostridium difficile and Clostridium perfringens coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogotá, Colombia', Gut Pathogens, vol. 11, n.º 1, 27. https://doi.org/10.1186/s13099-019-0308-7

High frequency of toxigenic Clostridium difficile and Clostridium perfringens coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogotá, Colombia. / Forero, Alex J.; Muñoz, Marina; Camargo, Milena et al.
En: Gut Pathogens, Vol. 11, N.º 1, 27, 03.06.2019.

Producción científica: Contribución a una revista › Artículo de Investigación › revisión exhaustiva

TY - JOUR

T1 - High frequency of toxigenic Clostridium difficile and Clostridium perfringens coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogotá, Colombia

AU - Forero, Alex J.

AU - Muñoz, Marina

AU - Camargo, Milena

AU - Soto-De León, Sara C.

AU - Ríos-Chaparro, Dora I.

AU - Birchenall, Claudia

AU - Pinilla, Darío

AU - Pardo Oviedo, Juan Mauricio

AU - Josa, Diego F.

AU - Patarroyo, Manuel A.

AU - Ramírez, Juan D.

PY - 2019/6/3

Y1 - 2019/6/3

N2 - Background: The aim of this study was to evaluate the frequency of toxigenic C. difficile and C. perfringens infections at health care facility-onset (HCFO) and community-onset (CO), in two health care centers (HCC) in Bogotá, Colombia. A total of 220 stool samples from patients presenting diarrhea acquired at HCFO or CO were analyzed by several PCR tests. Results: We found that 65.5% (n = 144) of the population had C. difficile infection, followed by toxigenic C. difficile with 57.3% (n = 126), and finally toxigenic C. perfringens with a frequency of 32.7% (n = 72). Conclusions: This study is the first molecular detection and characterization of C. difficile and C. perfringens in HCFO and CO in Latin America and demonstrates a relevant frequency of these two species, including coinfection and strikingly diverse toxigenic profiles, especially in the CO.

AB - Background: The aim of this study was to evaluate the frequency of toxigenic C. difficile and C. perfringens infections at health care facility-onset (HCFO) and community-onset (CO), in two health care centers (HCC) in Bogotá, Colombia. A total of 220 stool samples from patients presenting diarrhea acquired at HCFO or CO were analyzed by several PCR tests. Results: We found that 65.5% (n = 144) of the population had C. difficile infection, followed by toxigenic C. difficile with 57.3% (n = 126), and finally toxigenic C. perfringens with a frequency of 32.7% (n = 72). Conclusions: This study is the first molecular detection and characterization of C. difficile and C. perfringens in HCFO and CO in Latin America and demonstrates a relevant frequency of these two species, including coinfection and strikingly diverse toxigenic profiles, especially in the CO.

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U2 - 10.1186/s13099-019-0308-7

DO - 10.1186/s13099-019-0308-7

M3 - Research Article

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AN - SCOPUS:85066861681

SN - 1757-4749

VL - 11

JO - Gut Pathogens

JF - Gut Pathogens

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