High frequency of toxigenic Clostridium difficile and Clostridium perfringens coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogotá, Colombia

Alex J. Forero, Marina Muñoz, Milena Camargo, Sara C. Soto-De León, Dora I. Ríos-Chaparro, Claudia Birchenall, Darío Pinilla, Juan M. Pardo, Diego F. Josa, Manuel A. Patarroyo, Juan D. Ramírez

Resultado de la investigación: Contribución a una revistaArtículo

Resumen

Background: The aim of this study was to evaluate the frequency of toxigenic C. difficile and C. perfringens infections at health care facility-onset (HCFO) and community-onset (CO), in two health care centers (HCC) in Bogotá, Colombia. A total of 220 stool samples from patients presenting diarrhea acquired at HCFO or CO were analyzed by several PCR tests. Results: We found that 65.5% (n = 144) of the population had C. difficile infection, followed by toxigenic C. difficile with 57.3% (n = 126), and finally toxigenic C. perfringens with a frequency of 32.7% (n = 72). Conclusions: This study is the first molecular detection and characterization of C. difficile and C. perfringens in HCFO and CO in Latin America and demonstrates a relevant frequency of these two species, including coinfection and strikingly diverse toxigenic profiles, especially in the CO.

Idioma originalInglés estadounidense
Número de artículo27
PublicaciónGut Pathogens
Volumen11
N.º1
DOI
EstadoPublicada - jun 3 2019

All Science Journal Classification (ASJC) codes

  • Parasitología
  • Microbiología
  • Gastroenterología
  • Virología
  • Enfermedades infecciosas

Citar esto

Forero, Alex J. ; Muñoz, Marina ; Camargo, Milena ; Soto-De León, Sara C. ; Ríos-Chaparro, Dora I. ; Birchenall, Claudia ; Pinilla, Darío ; Pardo, Juan M. ; Josa, Diego F. ; Patarroyo, Manuel A. ; Ramírez, Juan D. / High frequency of toxigenic Clostridium difficile and Clostridium perfringens coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogotá, Colombia. En: Gut Pathogens. 2019 ; Vol. 11, N.º 1.
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title = "High frequency of toxigenic Clostridium difficile and Clostridium perfringens coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogot{\'a}, Colombia",
abstract = "Background: The aim of this study was to evaluate the frequency of toxigenic C. difficile and C. perfringens infections at health care facility-onset (HCFO) and community-onset (CO), in two health care centers (HCC) in Bogot{\'a}, Colombia. A total of 220 stool samples from patients presenting diarrhea acquired at HCFO or CO were analyzed by several PCR tests. Results: We found that 65.5{\%} (n = 144) of the population had C. difficile infection, followed by toxigenic C. difficile with 57.3{\%} (n = 126), and finally toxigenic C. perfringens with a frequency of 32.7{\%} (n = 72). Conclusions: This study is the first molecular detection and characterization of C. difficile and C. perfringens in HCFO and CO in Latin America and demonstrates a relevant frequency of these two species, including coinfection and strikingly diverse toxigenic profiles, especially in the CO.",
author = "Forero, {Alex J.} and Marina Mu{\~n}oz and Milena Camargo and {Soto-De Le{\'o}n}, {Sara C.} and R{\'i}os-Chaparro, {Dora I.} and Claudia Birchenall and Dar{\'i}o Pinilla and Pardo, {Juan M.} and Josa, {Diego F.} and Patarroyo, {Manuel A.} and Ram{\'i}rez, {Juan D.}",
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High frequency of toxigenic Clostridium difficile and Clostridium perfringens coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogotá, Colombia. / Forero, Alex J.; Muñoz, Marina; Camargo, Milena; Soto-De León, Sara C.; Ríos-Chaparro, Dora I.; Birchenall, Claudia; Pinilla, Darío; Pardo, Juan M.; Josa, Diego F.; Patarroyo, Manuel A.; Ramírez, Juan D.

En: Gut Pathogens, Vol. 11, N.º 1, 27, 03.06.2019.

Resultado de la investigación: Contribución a una revistaArtículo

TY - JOUR

T1 - High frequency of toxigenic Clostridium difficile and Clostridium perfringens coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogotá, Colombia

AU - Forero, Alex J.

AU - Muñoz, Marina

AU - Camargo, Milena

AU - Soto-De León, Sara C.

AU - Ríos-Chaparro, Dora I.

AU - Birchenall, Claudia

AU - Pinilla, Darío

AU - Pardo, Juan M.

AU - Josa, Diego F.

AU - Patarroyo, Manuel A.

AU - Ramírez, Juan D.

PY - 2019/6/3

Y1 - 2019/6/3

N2 - Background: The aim of this study was to evaluate the frequency of toxigenic C. difficile and C. perfringens infections at health care facility-onset (HCFO) and community-onset (CO), in two health care centers (HCC) in Bogotá, Colombia. A total of 220 stool samples from patients presenting diarrhea acquired at HCFO or CO were analyzed by several PCR tests. Results: We found that 65.5% (n = 144) of the population had C. difficile infection, followed by toxigenic C. difficile with 57.3% (n = 126), and finally toxigenic C. perfringens with a frequency of 32.7% (n = 72). Conclusions: This study is the first molecular detection and characterization of C. difficile and C. perfringens in HCFO and CO in Latin America and demonstrates a relevant frequency of these two species, including coinfection and strikingly diverse toxigenic profiles, especially in the CO.

AB - Background: The aim of this study was to evaluate the frequency of toxigenic C. difficile and C. perfringens infections at health care facility-onset (HCFO) and community-onset (CO), in two health care centers (HCC) in Bogotá, Colombia. A total of 220 stool samples from patients presenting diarrhea acquired at HCFO or CO were analyzed by several PCR tests. Results: We found that 65.5% (n = 144) of the population had C. difficile infection, followed by toxigenic C. difficile with 57.3% (n = 126), and finally toxigenic C. perfringens with a frequency of 32.7% (n = 72). Conclusions: This study is the first molecular detection and characterization of C. difficile and C. perfringens in HCFO and CO in Latin America and demonstrates a relevant frequency of these two species, including coinfection and strikingly diverse toxigenic profiles, especially in the CO.

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