Guillain-Barré syndrome: causes, immunopathogenic mechanisms and treatment

Anil K. Jasti, Carlo Selmi, Juan C. Sarmiento-Monroy, Daniel A. Vega, Juan Manuel Anaya, M. Eric Gershwin

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

57 Citas (Scopus)

Resumen

Introduction: Guillain-Barré syndrome is a rare disease representing the most frequent cause of acute flaccid symmetrical weakness of the limbs and areflexia usually reaching its peak within a month. The etiology and pathogenesis remain largely enigmatic and the syndrome results in death or severe disability in 9–17% of cases despite immunotherapy. Areas covered: In terms of etiology, Guillain-Barré syndrome is linked to Campylobacter infection but less than 0.1% of infections result in the syndrome. In terms of pathogenesis, activated macrophages and T cells and serum antibodies against gangliosides are observed but their significance is unclear. Expert commentary: Guillain-Barré syndrome is a heterogeneous condition with numerous subtypes and recent data point towards the role of ganglioside epitopes by immunohistochemical methods. Ultimately, the syndrome results from a permissive genetic background on which environmental factors, including infections, vaccination and the influence of aging, lead to disease.

Idioma originalInglés estadounidense
Páginas (desde-hasta)1175-1189
Número de páginas15
PublicaciónExpert Review of Clinical Immunology
Volumen12
N.º11
DOI
EstadoPublicada - nov. 1 2016

Áreas temáticas de ASJC Scopus

  • Inmulogía y alergología
  • Inmunología

Palabras claves de autor

  • Concepto
  • Molecular mimicry
  • immune tolerance
  • autoimmune neuropathy
  • Guillain-Barré
  • infection and immunity

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