Guillain-Barré syndrome: causes, immunopathogenic mechanisms and treatment

Anil K. Jasti, Carlo Selmi, Juan C. Sarmiento-Monroy, Daniel A. Vega, Juan Manuel Anaya, M. Eric Gershwin

Resultado de la investigación: Contribución a RevistaRevisión Literaria

18 Citas (Scopus)

Resumen

© 2016 Informa UK Limited, trading as Taylor & Francis Group.Introduction: Guillain-Barré syndrome is a rare disease representing the most frequent cause of acute flaccid symmetrical weakness of the limbs and areflexia usually reaching its peak within a month. The etiology and pathogenesis remain largely enigmatic and the syndrome results in death or severe disability in 9–17% of cases despite immunotherapy. Areas covered: In terms of etiology, Guillain-Barré syndrome is linked to Campylobacter infection but less than 0.1% of infections result in the syndrome. In terms of pathogenesis, activated macrophages and T cells and serum antibodies against gangliosides are observed but their significance is unclear. Expert commentary: Guillain-Barré syndrome is a heterogeneous condition with numerous subtypes and recent data point towards the role of ganglioside epitopes by immunohistochemical methods. Ultimately, the syndrome results from a permissive genetic background on which environmental factors, including infections, vaccination and the influence of aging, lead to disease.
Idioma originalEnglish (US)
Páginas (desde-hasta)1175-1189
Número de páginas15
PublicaciónExpert Review of Clinical Immunology
DOI
EstadoPublished - nov 1 2016

Huella dactilar

Guillain-Barre Syndrome
Gangliosides
Campylobacter Infections
Rare Diseases
Infection
Immunotherapy
Epitopes
Vaccination
Therapeutics
Extremities
Macrophages
T-Lymphocytes
Antibodies
Serum

Citar esto

Jasti, Anil K. ; Selmi, Carlo ; Sarmiento-Monroy, Juan C. ; Vega, Daniel A. ; Anaya, Juan Manuel ; Gershwin, M. Eric. / Guillain-Barré syndrome: causes, immunopathogenic mechanisms and treatment. En: Expert Review of Clinical Immunology. 2016 ; pp. 1175-1189.
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Guillain-Barré syndrome: causes, immunopathogenic mechanisms and treatment. / Jasti, Anil K.; Selmi, Carlo; Sarmiento-Monroy, Juan C.; Vega, Daniel A.; Anaya, Juan Manuel; Gershwin, M. Eric.

En: Expert Review of Clinical Immunology, 01.11.2016, p. 1175-1189.

Resultado de la investigación: Contribución a RevistaRevisión Literaria

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AU - Selmi, Carlo

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AU - Gershwin, M. Eric

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