Guillain-Barré syndrome associated with SARS-CoV-2 infection: A case series from 4 Colombian cities during the pandemic

N. Cerón Blanco; Jesus Hernán Rodríguez Quintana; M.C. Valencia Mendoza; C.A. Forero Botero; L. Rodríguez; S. Carrillo Villa; A. M. Gómez-Mazuera; J.A. Angarita Díaz; B. Uribe García; C. C. Bermúdez Riveros; J. Alban

doi:10.1016/j.neurop.2022.06.004

Guillain-Barré syndrome associated with SARS-CoV-2 infection: A case series from 4 Colombian cities during the pandemic

Título traducido de la contribución: Síndrome de Guillain Barré y Sars Cov2: serie de casos en el primer año de pandemia

N. Cerón Blanco
, Jesus Hernán Rodríguez Quintana
, M.C. Valencia Mendoza
, C.A. Forero Botero
, L. Rodríguez
, S. Carrillo Villa
, A. M. Gómez-Mazuera
, J.A. Angarita Díaz
, B. Uribe García
, C. C. Bermúdez Riveros
, J. Alban

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

1 Cita (Scopus)

Resumen

En el año 2020 se declaro la pandemia ocasionada por la infección por el virus SARSCoV-2, virus de la familia del coronavirus, adoptándose el nombre de COVID-19 a la enfermedad 1. En Bogotá, Colombia, se confirmó el primer caso de COVID-19 el 6 de marzo de 2020 (2). Los principales síntomas reportados en la infección por SARSCoV-2 son fiebre (43.8% en la admisión y 88.7% durante la hospitalización) y tos (67.8%) (3). Otros síntomas encontrados son fatiga (38.1%), producción de esputo (33.7%) y cefalea (13.6%). Los principales signos neurológicos reportados en los pacientes con infección severa por SARS-Cov-2 son agitación (69%), compromiso en tracto corticoespinal (67%) y delirium (65%) (4). Las principales complicaciones neurológicas descritas asociadas a Covid 19 son: anosmia, disgeusia, encefalopatia, Síndrome de Guillain Barre, complicaciones cerebrovasculares y daño en musculo esquelético (5–8).

En el presente articulo se presenta una serie de casos de pacientes con síndrome de Guillain-Barré asociado a infección por SARS-CoV-2. Se recolectaron casos de diferentes instituciones medicas de Colombia.

Título traducido de la contribución	Síndrome de Guillain Barré y Sars Cov2: serie de casos en el primer año de pandemia
Idioma original	Inglés estadounidense
Páginas (desde-hasta)	232-239
Número de páginas	8
Publicación	Neurology Perspectives
Volumen	2
N.º	4
DOI	https://doi.org/10.1016/j.neurop.2022.06.004
Estado	Publicada - 2022

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

ODS 3: Salud y bienestar

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Neurología

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Cerón Blanco, N., Rodríguez Quintana, J. H., Valencia Mendoza, M. C., Forero Botero, C. A., Rodríguez, L., Carrillo Villa, S., Gómez-Mazuera, A. M., Angarita Díaz, J. A., Uribe García, B., Bermúdez Riveros, C. C., & Alban, J. (2022). Guillain-Barré syndrome associated with SARS-CoV-2 infection: A case series from 4 Colombian cities during the pandemic. Neurology Perspectives, 2(4), 232-239. https://doi.org/10.1016/j.neurop.2022.06.004

@article{d0c683786ddf46a092162606d0b9136a,

title = "Guillain-Barr{\'e} syndrome associated with SARS-CoV-2 infection: A case series from 4 Colombian cities during the pandemic",

abstract = "SARS-CoV-2 infection has been associated with multiple neurological manifestations. One such manifestation, which has been described since the early stages of the COVID-19 pandemic and is relevant for current neurological practice, is Guillain-Barr{\'e} syndrome (GBS). The literature describes neurotoxic mechanisms of the virus itself and the possible pathways by which it may affect the peripheral nerves in experimental studies; however, we still lack information on the mechanisms causing the immune response that gives rise to GBS in the context of SARS-CoV-2 infection. Colombia is one of the Latin American countries worst affected by the pandemic, with the third-highest number of cases in the region; thus, it is essential to recognise GBS, as this potential postinfectious complication may severely compromise the patient's functional status in the absence of timely diagnosis and treatment. We present a series of 12 cases of GBS associated with SARS-CoV-2 infection from hospitals in 4 different Colombian cities and describe the clinical presentation, laboratory and electrophysiological study findings, and treatment.",

author = "\{Cer{\'o}n Blanco\}, N. and \{Rodr{\'i}guez Quintana\}, \{Jesus Hern{\'a}n\} and \{Valencia Mendoza\}, M.C. and \{Forero Botero\}, C.A. and L. Rodr{\'i}guez and \{Carrillo Villa\}, S. and G{\'o}mez-Mazuera, \{A. M.\} and \{Angarita D{\'i}az\}, J.A. and \{Uribe Garc{\'i}a\}, B. and \{Berm{\'u}dez Riveros\}, \{C. C.\} and J. Alban",

year = "2022",

doi = "10.1016/j.neurop.2022.06.004",

language = "English (US)",

volume = "2",

pages = "232--239",

number = "4",

}

Cerón Blanco, N, Rodríguez Quintana, JH, Valencia Mendoza, MC, Forero Botero, CA, Rodríguez, L, Carrillo Villa, S, Gómez-Mazuera, AM, Angarita Díaz, JA, Uribe García, B, Bermúdez Riveros, CC & Alban, J 2022, 'Guillain-Barré syndrome associated with SARS-CoV-2 infection: A case series from 4 Colombian cities during the pandemic', Neurology Perspectives, vol. 2, n.º 4, pp. 232-239. https://doi.org/10.1016/j.neurop.2022.06.004

Guillain-Barré syndrome associated with SARS-CoV-2 infection: A case series from 4 Colombian cities during the pandemic. / Cerón Blanco, N.; Rodríguez Quintana, Jesus Hernán; Valencia Mendoza, M.C. et al.
En: Neurology Perspectives, Vol. 2, N.º 4, 2022, p. 232-239.

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

TY - JOUR

T1 - Guillain-Barré syndrome associated with SARS-CoV-2 infection: A case series from 4 Colombian cities during the pandemic

AU - Cerón Blanco, N.

AU - Rodríguez Quintana, Jesus Hernán

AU - Valencia Mendoza, M.C.

AU - Forero Botero, C.A.

AU - Rodríguez, L.

AU - Carrillo Villa, S.

AU - Gómez-Mazuera, A. M.

AU - Angarita Díaz, J.A.

AU - Uribe García, B.

AU - Bermúdez Riveros, C. C.

AU - Alban, J.

PY - 2022

Y1 - 2022

N2 - SARS-CoV-2 infection has been associated with multiple neurological manifestations. One such manifestation, which has been described since the early stages of the COVID-19 pandemic and is relevant for current neurological practice, is Guillain-Barré syndrome (GBS). The literature describes neurotoxic mechanisms of the virus itself and the possible pathways by which it may affect the peripheral nerves in experimental studies; however, we still lack information on the mechanisms causing the immune response that gives rise to GBS in the context of SARS-CoV-2 infection. Colombia is one of the Latin American countries worst affected by the pandemic, with the third-highest number of cases in the region; thus, it is essential to recognise GBS, as this potential postinfectious complication may severely compromise the patient's functional status in the absence of timely diagnosis and treatment. We present a series of 12 cases of GBS associated with SARS-CoV-2 infection from hospitals in 4 different Colombian cities and describe the clinical presentation, laboratory and electrophysiological study findings, and treatment.

AB - SARS-CoV-2 infection has been associated with multiple neurological manifestations. One such manifestation, which has been described since the early stages of the COVID-19 pandemic and is relevant for current neurological practice, is Guillain-Barré syndrome (GBS). The literature describes neurotoxic mechanisms of the virus itself and the possible pathways by which it may affect the peripheral nerves in experimental studies; however, we still lack information on the mechanisms causing the immune response that gives rise to GBS in the context of SARS-CoV-2 infection. Colombia is one of the Latin American countries worst affected by the pandemic, with the third-highest number of cases in the region; thus, it is essential to recognise GBS, as this potential postinfectious complication may severely compromise the patient's functional status in the absence of timely diagnosis and treatment. We present a series of 12 cases of GBS associated with SARS-CoV-2 infection from hospitals in 4 different Colombian cities and describe the clinical presentation, laboratory and electrophysiological study findings, and treatment.

U2 - 10.1016/j.neurop.2022.06.004

DO - 10.1016/j.neurop.2022.06.004

M3 - Research Article

C2 - 37521143

SN - 2667-0496

VL - 2

SP - 232

EP - 239

JO - Neurology Perspectives

JF - Neurology Perspectives

IS - 4

ER -

Guillain-Barré syndrome associated with SARS-CoV-2 infection: A case series from 4 Colombian cities during the pandemic

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