Gluten sensitivity in multiple sclerosis: Experimental myth or clinical truth

Dana Ben Ami Shor, Ori Barzilai, Maya Ram, David Izhaky, Bat Sheva Porat-Katz, Joab Chapman, Miri Blank, Juan Manuel Anaya, Yehuda Shoenfeld

Resultado de la investigación: Capítulo en Libro/Reporte/ConferenciaContribución a la conferencia

29 Citas (Scopus)

Resumen

Patients with neurological disease of unknown etiology sometimes present with antigliadin and antitissue transglutaminase antibodies. The association between these antibodies and multiple sclerosis has been previously suggested. The purpose of this study was to determine the prevalence of these antibodies in multiple sclerosis patients. We determined the level of serum immunoglobulin A and immunoglobulin G antigliadin and antitissue transglutaminase antibodies in 98 patients with multiple sclerosis. We found a highly significant increase in titers of immunoglobulin G antibodies against gliadin and tissue transglutaminase in the multiple sclerosis patients. Seven patients had a positive IgG AGA, whereas only 2 controls presented positive titers (P = 0.03). Four patients had positive IgG anti-tTG while all the controls tested negative (P = 0.02). However, immunoglobulin A antibodies against gliadin and tissue transglutaminase were not statistically higher in the multiple sclerosis group in comparison to the control group. Our findings support the associations between antibodies against gliadin and tissue transglutaminase to multiple sclerosis. The specific role of these antibodies in the pathogenesis of multiple sclerosis remains uncertain and requires additional research. A gluten free diet should be considered in specific cases of patients who present with gluten antibodies.

Idioma originalInglés estadounidense
Título de la publicación alojadaContemporary Challenges in Autoimmunity
EditorialBlackwell Publishing, Inc.
Páginas343-349
Número de páginas7
ISBN (versión impresa)9781573317627
DOI
EstadoPublicada - sep 2009

Serie de la publicación

NombreAnnals of the New York Academy of Sciences
Volumen1173
ISSN (versión impresa)0077-8923
ISSN (versión digital)1749-6632

All Science Journal Classification (ASJC) codes

  • Neurociencia (todo)
  • Bioquímica, genética y biología molecular (todo)
  • Historia y filosofía de la ciencia

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