Genomic characterization of SARS-CoV-2 and its association with clinical outcomes: a 1-year longitudinal study of the pandemic in Colombia: a 1-year longitudinal study of the pandemic in Colombia

Ángela María Ruiz-Sternberg; Henry Mauricio Chaparro-Solano; Ludwig L. Albornóz; Ángela María Pinzón-Rondón; Juan Mauricio Pardo-Oviedo; Nicolás Molano-González; Diego Andrés Otero-Rodríguez; Fabio Andrés Zapata-Gómez; Jubby Marcela Gálvez

doi:10.1016/j.ijid.2021.12.326

Genomic characterization of SARS-CoV-2 and its association with clinical outcomes: a 1-year longitudinal study of the pandemic in Colombia: a 1-year longitudinal study of the pandemic in Colombia

Título traducido de la contribución: Caracterización genómica del SARS-CoV-2 y su asociación con los resultados clínicos: estudio longitudinal de 1 año de la pandemia en Colombia

Ángela María Ruiz-Sternberg, Henry Mauricio Chaparro-Solano, Ludwig L. Albornóz, Ángela María Pinzón-Rondón, Juan Mauricio Pardo-Oviedo, Nicolás Molano-González, Diego Andrés Otero-Rodríguez, Fabio Andrés Zapata-Gómez, Jubby Marcela Gálvez

Producción científica: Contribución a una revista › Artículo de Investigación › revisión exhaustiva

6 Citas (Scopus)

Resumen

Objetivos: Este estudio tuvo como objetivo explorar las asociaciones entre la caracterización molecular del coronavirus-2 del síndrome respiratorio agudo severo (SARS-CoV-2) y la gravedad de la enfermedad en pacientes ambulatorios y hospitalizados en dos epicentros principales de Colombia durante el primer año de la pandemia de la enfermedad por coronavirus 2019. Métodos: En total, 1000 pacientes con infección por SARS-CoV-2 fueron incluidos en este estudio. Se recogieron datos clínicos de 997 pacientes y se obtuvieron 678 secuencias de genoma completo mediante secuenciación masiva en paralelo. Se realizaron análisis bivariantes, multivariantes y de árbol de clasificación y regresión entre variables clínicas y genómicas. Resultados: La edad >88 años y la infección por los linajes B.1.1, B.1.1.388, B.1.523 o B.1.621 en pacientes de 71-88 años se asociaron con la muerte [odds ratio (OR) 6,048036; intervalo de confianza (IC) del 95%: 1,346567-32,92521; p=0,01718674]. La necesidad de hospitalización se asoció a mayor edad y comorbilidades. La tasa de hospitalización aumentó significativamente en los pacientes de 38-51 años infectados por los linajes A, B, B.1.1.388, B.1.1.434, B.1.153, B.1.36.10, B.1.411, B.1.471, B.1.558 o B.1.621 (OR 8.368427, IC 95% 2.573145-39.10672, P=0.00012). Las asociaciones entre los clados y los resultados clínicos divergieron de los datos comunicados previamente. Conclusiones: La infección por el linaje B.1.621 aumentó las tasas de hospitalización y mortalidad. Estos hallazgos, más el rápido aumento de la prevalencia en Colombia y otros países, sugieren que el linaje B.1.621 debe considerarse como una "variante de interés". Si se confirma la gravedad de la enfermedad asociada, debería considerarse su posible designación como 'variante de interés'.

Título traducido de la contribución	Caracterización genómica del SARS-CoV-2 y su asociación con los resultados clínicos: estudio longitudinal de 1 año de la pandemia en Colombia
Idioma original	Inglés estadounidense
Páginas (desde-hasta)	91-100
Número de páginas	10
Publicación	International Journal of Infectious Diseases
Volumen	116
Fecha en línea anticipada	dic. 15 2021
DOI	https://doi.org/10.1016/j.ijid.2021.12.326
Estado	Publicada - mar. 2022

Áreas temáticas de ASJC Scopus

Microbiología (médica)
Enfermedades infecciosas

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

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Ruiz-Sternberg, Á. M., Chaparro-Solano, H. M., Albornóz, L. L., Pinzón-Rondón, Á. M., Pardo-Oviedo, J. M., Molano-González, N., Otero-Rodríguez, D. A., Zapata-Gómez, F. A., & Gálvez, J. M. (2022). Genomic characterization of SARS-CoV-2 and its association with clinical outcomes: a 1-year longitudinal study of the pandemic in Colombia: a 1-year longitudinal study of the pandemic in Colombia. International Journal of Infectious Diseases, 116, 91-100. https://doi.org/10.1016/j.ijid.2021.12.326

Ruiz-Sternberg, Ángela María ; Chaparro-Solano, Henry Mauricio ; Albornóz, Ludwig L. et al. / Genomic characterization of SARS-CoV-2 and its association with clinical outcomes: a 1-year longitudinal study of the pandemic in Colombia : a 1-year longitudinal study of the pandemic in Colombia. En: International Journal of Infectious Diseases. 2022 ; Vol. 116. pp. 91-100.

@article{f2b0c33755064a738d4d8a45285084da,

title = "Genomic characterization of SARS-CoV-2 and its association with clinical outcomes: a 1-year longitudinal study of the pandemic in Colombia: a 1-year longitudinal study of the pandemic in Colombia",

abstract = "Objectives: This study aimed to explore associations between the molecular characterization of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and disease severity in ambulatory and hospitalized patients in two main Colombian epicentres during the first year of the coronavirus disease 2019 pandemic. Methods: In total, 1000 patients with SARS-CoV-2 infection were included in this study. Clinical data were collected from 997 patients, and 678 whole-genome sequences were obtained by massively parallel sequencing. Bivariate, multi-variate, and classification and regression tree analyses were run between clinical and genomic variables. Results: Age >88 years, and infection with lineages B.1.1, B.1.1.388, B.1.523 or B.1.621 for patients aged 71–88 years were associated with death [odds ratio (OR) 6.048036, 95% confidence interval (CI) 1.346567–32.92521; P=0.01718674]. The need for hospitalization was associated with higher age and comorbidities. The hospitalization rate increased significantly for patients aged 38–51 years infected with lineages A, B, B.1.1.388, B.1.1.434, B.1.153, B.1.36.10, B.1.411, B.1.471, B.1.558 or B.1.621 (OR 8.368427, 95% CI 2.573145–39.10672, P=0.00012). Associations between clades and clinical outcomes diverged from previously reported data. Conclusions: Infection with lineage B.1.621 increased the hospitalization and mortality rates. These findings, plus the rapidly increasing prevalence in Colombia and other countries, suggest that lineage B.1.621 should be considered as a {\textquoteleft}variant of interest{\textquoteright}. If associated disease severity is confirmed, possible designation as a {\textquoteleft}variant of concern{\textquoteright} should be considered.",

author = "Ruiz-Sternberg, {{\'A}ngela Mar{\'i}a} and Chaparro-Solano, {Henry Mauricio} and Alborn{\'o}z, {Ludwig L.} and Pinz{\'o}n-Rond{\'o}n, {{\'A}ngela Mar{\'i}a} and Pardo-Oviedo, {Juan Mauricio} and Nicol{\'a}s Molano-Gonz{\'a}lez and Otero-Rodr{\'i}guez, {Diego Andr{\'e}s} and Zapata-G{\'o}mez, {Fabio Andr{\'e}s} and G{\'a}lvez, {Jubby Marcela}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2022",

month = mar,

doi = "10.1016/j.ijid.2021.12.326",

language = "English (US)",

volume = "116",

pages = "91--100",

journal = "International Journal of Infectious Diseases",

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Ruiz-Sternberg, ÁM, Chaparro-Solano, HM, Albornóz, LL, Pinzón-Rondón, ÁM , Pardo-Oviedo, JM , Molano-González, N, Otero-Rodríguez, DA, Zapata-Gómez, FA & Gálvez, JM 2022, 'Genomic characterization of SARS-CoV-2 and its association with clinical outcomes: a 1-year longitudinal study of the pandemic in Colombia: a 1-year longitudinal study of the pandemic in Colombia', International Journal of Infectious Diseases, vol. 116, pp. 91-100. https://doi.org/10.1016/j.ijid.2021.12.326

Genomic characterization of SARS-CoV-2 and its association with clinical outcomes: a 1-year longitudinal study of the pandemic in Colombia: a 1-year longitudinal study of the pandemic in Colombia. / Ruiz-Sternberg, Ángela María; Chaparro-Solano, Henry Mauricio; Albornóz, Ludwig L. et al.
En: International Journal of Infectious Diseases, Vol. 116, 03.2022, p. 91-100.

Producción científica: Contribución a una revista › Artículo de Investigación › revisión exhaustiva

TY - JOUR

T1 - Genomic characterization of SARS-CoV-2 and its association with clinical outcomes: a 1-year longitudinal study of the pandemic in Colombia

T2 - a 1-year longitudinal study of the pandemic in Colombia

AU - Ruiz-Sternberg, Ángela María

AU - Chaparro-Solano, Henry Mauricio

AU - Albornóz, Ludwig L.

AU - Pinzón-Rondón, Ángela María

AU - Pardo-Oviedo, Juan Mauricio

AU - Molano-González, Nicolás

AU - Otero-Rodríguez, Diego Andrés

AU - Zapata-Gómez, Fabio Andrés

AU - Gálvez, Jubby Marcela

PY - 2022/3

Y1 - 2022/3

N2 - Objectives: This study aimed to explore associations between the molecular characterization of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and disease severity in ambulatory and hospitalized patients in two main Colombian epicentres during the first year of the coronavirus disease 2019 pandemic. Methods: In total, 1000 patients with SARS-CoV-2 infection were included in this study. Clinical data were collected from 997 patients, and 678 whole-genome sequences were obtained by massively parallel sequencing. Bivariate, multi-variate, and classification and regression tree analyses were run between clinical and genomic variables. Results: Age >88 years, and infection with lineages B.1.1, B.1.1.388, B.1.523 or B.1.621 for patients aged 71–88 years were associated with death [odds ratio (OR) 6.048036, 95% confidence interval (CI) 1.346567–32.92521; P=0.01718674]. The need for hospitalization was associated with higher age and comorbidities. The hospitalization rate increased significantly for patients aged 38–51 years infected with lineages A, B, B.1.1.388, B.1.1.434, B.1.153, B.1.36.10, B.1.411, B.1.471, B.1.558 or B.1.621 (OR 8.368427, 95% CI 2.573145–39.10672, P=0.00012). Associations between clades and clinical outcomes diverged from previously reported data. Conclusions: Infection with lineage B.1.621 increased the hospitalization and mortality rates. These findings, plus the rapidly increasing prevalence in Colombia and other countries, suggest that lineage B.1.621 should be considered as a ‘variant of interest’. If associated disease severity is confirmed, possible designation as a ‘variant of concern’ should be considered.

AB - Objectives: This study aimed to explore associations between the molecular characterization of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and disease severity in ambulatory and hospitalized patients in two main Colombian epicentres during the first year of the coronavirus disease 2019 pandemic. Methods: In total, 1000 patients with SARS-CoV-2 infection were included in this study. Clinical data were collected from 997 patients, and 678 whole-genome sequences were obtained by massively parallel sequencing. Bivariate, multi-variate, and classification and regression tree analyses were run between clinical and genomic variables. Results: Age >88 years, and infection with lineages B.1.1, B.1.1.388, B.1.523 or B.1.621 for patients aged 71–88 years were associated with death [odds ratio (OR) 6.048036, 95% confidence interval (CI) 1.346567–32.92521; P=0.01718674]. The need for hospitalization was associated with higher age and comorbidities. The hospitalization rate increased significantly for patients aged 38–51 years infected with lineages A, B, B.1.1.388, B.1.1.434, B.1.153, B.1.36.10, B.1.411, B.1.471, B.1.558 or B.1.621 (OR 8.368427, 95% CI 2.573145–39.10672, P=0.00012). Associations between clades and clinical outcomes diverged from previously reported data. Conclusions: Infection with lineage B.1.621 increased the hospitalization and mortality rates. These findings, plus the rapidly increasing prevalence in Colombia and other countries, suggest that lineage B.1.621 should be considered as a ‘variant of interest’. If associated disease severity is confirmed, possible designation as a ‘variant of concern’ should be considered.

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DO - 10.1016/j.ijid.2021.12.326

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Ruiz-Sternberg ÁM, Chaparro-Solano HM, Albornóz LL, Pinzón-Rondón ÁM , Pardo-Oviedo JM , Molano-González N et al. Genomic characterization of SARS-CoV-2 and its association with clinical outcomes: a 1-year longitudinal study of the pandemic in Colombia: a 1-year longitudinal study of the pandemic in Colombia. International Journal of Infectious Diseases. 2022 mar.;116:91-100. Epub 2021 dic. 15. doi: 10.1016/j.ijid.2021.12.326