Genomic architecture of adaptive color pattern divergence and convergence in Heliconius butterflies

Megan A. Supple, Heather M. Hines, Kanchon K. Dasmahapatra, James J. Lewis, Dahlia M. Nielsen, Christine Lavoie, David A. Ray, Camilo Salazar, W. Owen McMillan, Brian A. Counterman

Resultado de la investigación: Contribución a RevistaArtículo

37 Citas (Scopus)

Resumen

Identifying the genetic changes driving adaptive variation in natural populations is key to understanding the origins of biodiversity. The mosaic of mimetic wing patterns in Heliconius butterflies makes an excellent system for exploring adaptive variation using next-generation sequencing. In this study, we use a combination of techniques to annotate the genomic interval modulating red color pattern variation, identify a narrow region responsible for adaptive divergence and convergence in Heliconius wing color patterns, and explore the evolutionary history of these adaptive alleles. We use whole genome resequencing from four hybrid zones between divergent color pattern races of Heliconius erato and two hybrid zones of the co-mimic Heliconius melpomene to examine genetic variation across 2.2 Mb of a partial reference sequence. In the intergenic region near optix, the gene previously shown to be responsible for the complex red pattern variation in Heliconius, population genetic analyses identify a shared 65-kb region of divergence that includes several sites perfectly associated with phenotype within each species. This region likely contains multiple cis-regulatory elements that control discrete expression domains of optix. The parallel signatures of genetic differentiation in H. erato and H. melpomene support a shared genetic architecture between the two distantly related co-mimics; however, phylogenetic analysis suggests mimetic patterns in each species evolved independently. Using a combination of next-generation sequencing analyses, we have refined our understanding of the genetic architecture of wing pattern variation in Heliconius and gained important insights into the evolution of novel adaptive phenotypes in natural populations. © 2013, Published by Cold Spring Harbor Laboratory Press.
Idioma originalEnglish (US)
Páginas (desde-hasta)1248-1257
Número de páginas10
PublicaciónGenome Research
DOI
EstadoPublished - ago 1 2013

Huella dactilar

Butterflies
Color
Phenotype
Intergenic DNA
Biodiversity
Population Genetics
Population
History
Alleles
Genome
Genes

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Supple, M. A., Hines, H. M., Dasmahapatra, K. K., Lewis, J. J., Nielsen, D. M., Lavoie, C., ... Counterman, B. A. (2013). Genomic architecture of adaptive color pattern divergence and convergence in Heliconius butterflies. Genome Research, 1248-1257. https://doi.org/10.1101/gr.150615.112
Supple, Megan A. ; Hines, Heather M. ; Dasmahapatra, Kanchon K. ; Lewis, James J. ; Nielsen, Dahlia M. ; Lavoie, Christine ; Ray, David A. ; Salazar, Camilo ; McMillan, W. Owen ; Counterman, Brian A. / Genomic architecture of adaptive color pattern divergence and convergence in Heliconius butterflies. En: Genome Research. 2013 ; pp. 1248-1257.
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abstract = "Identifying the genetic changes driving adaptive variation in natural populations is key to understanding the origins of biodiversity. The mosaic of mimetic wing patterns in Heliconius butterflies makes an excellent system for exploring adaptive variation using next-generation sequencing. In this study, we use a combination of techniques to annotate the genomic interval modulating red color pattern variation, identify a narrow region responsible for adaptive divergence and convergence in Heliconius wing color patterns, and explore the evolutionary history of these adaptive alleles. We use whole genome resequencing from four hybrid zones between divergent color pattern races of Heliconius erato and two hybrid zones of the co-mimic Heliconius melpomene to examine genetic variation across 2.2 Mb of a partial reference sequence. In the intergenic region near optix, the gene previously shown to be responsible for the complex red pattern variation in Heliconius, population genetic analyses identify a shared 65-kb region of divergence that includes several sites perfectly associated with phenotype within each species. This region likely contains multiple cis-regulatory elements that control discrete expression domains of optix. The parallel signatures of genetic differentiation in H. erato and H. melpomene support a shared genetic architecture between the two distantly related co-mimics; however, phylogenetic analysis suggests mimetic patterns in each species evolved independently. Using a combination of next-generation sequencing analyses, we have refined our understanding of the genetic architecture of wing pattern variation in Heliconius and gained important insights into the evolution of novel adaptive phenotypes in natural populations. {\circledC} 2013, Published by Cold Spring Harbor Laboratory Press.",
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Supple, MA, Hines, HM, Dasmahapatra, KK, Lewis, JJ, Nielsen, DM, Lavoie, C, Ray, DA, Salazar, C, McMillan, WO & Counterman, BA 2013, 'Genomic architecture of adaptive color pattern divergence and convergence in Heliconius butterflies', Genome Research, pp. 1248-1257. https://doi.org/10.1101/gr.150615.112

Genomic architecture of adaptive color pattern divergence and convergence in Heliconius butterflies. / Supple, Megan A.; Hines, Heather M.; Dasmahapatra, Kanchon K.; Lewis, James J.; Nielsen, Dahlia M.; Lavoie, Christine; Ray, David A.; Salazar, Camilo; McMillan, W. Owen; Counterman, Brian A.

En: Genome Research, 01.08.2013, p. 1248-1257.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Genomic architecture of adaptive color pattern divergence and convergence in Heliconius butterflies

AU - Supple, Megan A.

AU - Hines, Heather M.

AU - Dasmahapatra, Kanchon K.

AU - Lewis, James J.

AU - Nielsen, Dahlia M.

AU - Lavoie, Christine

AU - Ray, David A.

AU - Salazar, Camilo

AU - McMillan, W. Owen

AU - Counterman, Brian A.

PY - 2013/8/1

Y1 - 2013/8/1

N2 - Identifying the genetic changes driving adaptive variation in natural populations is key to understanding the origins of biodiversity. The mosaic of mimetic wing patterns in Heliconius butterflies makes an excellent system for exploring adaptive variation using next-generation sequencing. In this study, we use a combination of techniques to annotate the genomic interval modulating red color pattern variation, identify a narrow region responsible for adaptive divergence and convergence in Heliconius wing color patterns, and explore the evolutionary history of these adaptive alleles. We use whole genome resequencing from four hybrid zones between divergent color pattern races of Heliconius erato and two hybrid zones of the co-mimic Heliconius melpomene to examine genetic variation across 2.2 Mb of a partial reference sequence. In the intergenic region near optix, the gene previously shown to be responsible for the complex red pattern variation in Heliconius, population genetic analyses identify a shared 65-kb region of divergence that includes several sites perfectly associated with phenotype within each species. This region likely contains multiple cis-regulatory elements that control discrete expression domains of optix. The parallel signatures of genetic differentiation in H. erato and H. melpomene support a shared genetic architecture between the two distantly related co-mimics; however, phylogenetic analysis suggests mimetic patterns in each species evolved independently. Using a combination of next-generation sequencing analyses, we have refined our understanding of the genetic architecture of wing pattern variation in Heliconius and gained important insights into the evolution of novel adaptive phenotypes in natural populations. © 2013, Published by Cold Spring Harbor Laboratory Press.

AB - Identifying the genetic changes driving adaptive variation in natural populations is key to understanding the origins of biodiversity. The mosaic of mimetic wing patterns in Heliconius butterflies makes an excellent system for exploring adaptive variation using next-generation sequencing. In this study, we use a combination of techniques to annotate the genomic interval modulating red color pattern variation, identify a narrow region responsible for adaptive divergence and convergence in Heliconius wing color patterns, and explore the evolutionary history of these adaptive alleles. We use whole genome resequencing from four hybrid zones between divergent color pattern races of Heliconius erato and two hybrid zones of the co-mimic Heliconius melpomene to examine genetic variation across 2.2 Mb of a partial reference sequence. In the intergenic region near optix, the gene previously shown to be responsible for the complex red pattern variation in Heliconius, population genetic analyses identify a shared 65-kb region of divergence that includes several sites perfectly associated with phenotype within each species. This region likely contains multiple cis-regulatory elements that control discrete expression domains of optix. The parallel signatures of genetic differentiation in H. erato and H. melpomene support a shared genetic architecture between the two distantly related co-mimics; however, phylogenetic analysis suggests mimetic patterns in each species evolved independently. Using a combination of next-generation sequencing analyses, we have refined our understanding of the genetic architecture of wing pattern variation in Heliconius and gained important insights into the evolution of novel adaptive phenotypes in natural populations. © 2013, Published by Cold Spring Harbor Laboratory Press.

U2 - 10.1101/gr.150615.112

DO - 10.1101/gr.150615.112

M3 - Article

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SP - 1248

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JO - Genome Research

JF - Genome Research

SN - 1088-9051

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Supple MA, Hines HM, Dasmahapatra KK, Lewis JJ, Nielsen DM, Lavoie C y otros. Genomic architecture of adaptive color pattern divergence and convergence in Heliconius butterflies. Genome Research. 2013 ago 1;1248-1257. https://doi.org/10.1101/gr.150615.112