Genetics and autoantibodies

Carlo Perricone, Nancy Agmon-Levin, Fulvia Ceccarelli, Guido Valesini, Juan Manuel Anaya, Yehuda Shoenfeld

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

25 Citas (Scopus)


Autoimmune diseases (ADs) are chronic conditions initiated by the loss of immunological tolerance to self-antigens. The pathogenic hypothesis comprises a complex interaction between genetic, environmental and hormonal factors that interact with an individual over time generating a dysregulation of the immune system leading to disease development. Several polymorphic genes contribute to the development of ADs. Furthermore, age and gender play a major role by influencing hormone levels that can represent the fulcrum unbalancing from susceptibility to protection. Evidences suggest that while all these steps occur, the susceptible individual develops autoantibodies over a long time lapse. Such autoantibody production is genetically determined and finally, their presence seems to determine the clinical presentation of ADs. The genetic predisposition to the developments of autoantibodies and toward the disease process may overlap. The unveiling of these mechanisms could allow not only to treat but also to prevent the development of autoimmune diseases.

Idioma originalInglés estadounidense
Páginas (desde-hasta)206-219
Número de páginas14
PublicaciónImmunologic Research
EstadoPublicada - jul. 2013

Áreas temáticas de ASJC Scopus

  • Inmunología


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