Genetics and autoantibodies

Carlo Perricone, Nancy Agmon-Levin, Fulvia Ceccarelli, Guido Valesini, Juan-Manuel Anaya, Yehuda Shoenfeld

Resultado de la investigación: Contribución a RevistaArtículo de revisión

19 Citas (Scopus)

Resumen

Autoimmune diseases (ADs) are chronic conditions initiated by the loss of immunological tolerance to self-antigens. The pathogenic hypothesis comprises a complex interaction between genetic, environmental and hormonal factors that interact with an individual over time generating a dysregulation of the immune system leading to disease development. Several polymorphic genes contribute to the development of ADs. Furthermore, age and gender play a major role by influencing hormone levels that can represent the fulcrum unbalancing from susceptibility to protection. Evidences suggest that while all these steps occur, the susceptible individual develops autoantibodies over a long time lapse. Such autoantibody production is genetically determined and finally, their presence seems to determine the clinical presentation of ADs. The genetic predisposition to the developments of autoantibodies and toward the disease process may overlap. The unveiling of these mechanisms could allow not only to treat but also to prevent the development of autoimmune diseases.

Idioma originalEnglish (US)
Páginas (desde-hasta)206-19
Número de páginas14
PublicaciónImmunologic Research
Volumen56
N.º2-3
DOI
EstadoPublished - jul 2013

Huella dactilar

Autoantibodies
Autoimmune Diseases
Autoantigens
Genetic Predisposition to Disease
Immune System
Hormones
Genes

Citar esto

Perricone, C., Agmon-Levin, N., Ceccarelli, F., Valesini, G., Anaya, J-M., & Shoenfeld, Y. (2013). Genetics and autoantibodies. Immunologic Research, 56(2-3), 206-19. https://doi.org/10.1007/s12026-013-8396-9
Perricone, Carlo ; Agmon-Levin, Nancy ; Ceccarelli, Fulvia ; Valesini, Guido ; Anaya, Juan-Manuel ; Shoenfeld, Yehuda. / Genetics and autoantibodies. En: Immunologic Research. 2013 ; Vol. 56, N.º 2-3. pp. 206-19.
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abstract = "Autoimmune diseases (ADs) are chronic conditions initiated by the loss of immunological tolerance to self-antigens. The pathogenic hypothesis comprises a complex interaction between genetic, environmental and hormonal factors that interact with an individual over time generating a dysregulation of the immune system leading to disease development. Several polymorphic genes contribute to the development of ADs. Furthermore, age and gender play a major role by influencing hormone levels that can represent the fulcrum unbalancing from susceptibility to protection. Evidences suggest that while all these steps occur, the susceptible individual develops autoantibodies over a long time lapse. Such autoantibody production is genetically determined and finally, their presence seems to determine the clinical presentation of ADs. The genetic predisposition to the developments of autoantibodies and toward the disease process may overlap. The unveiling of these mechanisms could allow not only to treat but also to prevent the development of autoimmune diseases.",
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Perricone, C, Agmon-Levin, N, Ceccarelli, F, Valesini, G, Anaya, J-M & Shoenfeld, Y 2013, 'Genetics and autoantibodies', Immunologic Research, vol. 56, n.º 2-3, pp. 206-19. https://doi.org/10.1007/s12026-013-8396-9

Genetics and autoantibodies. / Perricone, Carlo; Agmon-Levin, Nancy; Ceccarelli, Fulvia; Valesini, Guido; Anaya, Juan-Manuel; Shoenfeld, Yehuda.

En: Immunologic Research, Vol. 56, N.º 2-3, 07.2013, p. 206-19.

Resultado de la investigación: Contribución a RevistaArtículo de revisión

TY - JOUR

T1 - Genetics and autoantibodies

AU - Perricone, Carlo

AU - Agmon-Levin, Nancy

AU - Ceccarelli, Fulvia

AU - Valesini, Guido

AU - Anaya, Juan-Manuel

AU - Shoenfeld, Yehuda

PY - 2013/7

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AB - Autoimmune diseases (ADs) are chronic conditions initiated by the loss of immunological tolerance to self-antigens. The pathogenic hypothesis comprises a complex interaction between genetic, environmental and hormonal factors that interact with an individual over time generating a dysregulation of the immune system leading to disease development. Several polymorphic genes contribute to the development of ADs. Furthermore, age and gender play a major role by influencing hormone levels that can represent the fulcrum unbalancing from susceptibility to protection. Evidences suggest that while all these steps occur, the susceptible individual develops autoantibodies over a long time lapse. Such autoantibody production is genetically determined and finally, their presence seems to determine the clinical presentation of ADs. The genetic predisposition to the developments of autoantibodies and toward the disease process may overlap. The unveiling of these mechanisms could allow not only to treat but also to prevent the development of autoimmune diseases.

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Perricone C, Agmon-Levin N, Ceccarelli F, Valesini G, Anaya J-M, Shoenfeld Y. Genetics and autoantibodies. Immunologic Research. 2013 jul;56(2-3):206-19. https://doi.org/10.1007/s12026-013-8396-9