Genetic epidemiology of rheumatoid arthritis: what to expect from Latin America?

Angélica María Delgado-Vega, Javier Martín, Julio Granados, Juan Manuel Anaya

Resultado de la investigación: Contribución a RevistaRevisión Literaria

20 Citas (Scopus)

Resumen

Rheumatoid arthritis is a chronic and systemic autoimmune disease characterized by inflammation and destruction of the synovial joints. It affects approximately 0.5% of the Latin-American population and is three times more common in women than in men. Evidence of familial aggregation (lambdas=2-17) was the first indication of a genetic susceptibility to disease. As in other autoimmune diseases, it has a complex genetic basis. Results from whole-genome scans indicate that the HLA region contains a significant and consistent set of linked loci. However, HLA accounts for only one-third of the genetic susceptibility of disease, indicating that non-HLA genes are also involved in the disease susceptibility. In Latin-America, association with HLA-DRB1*0404 and TNF -308A alleles has been uniformly established; however, many other candidate genes remain to be studied. The identification of genetic factors conferring susceptibility to rheumatoid arthritis will contribute to the knowledge of the pathogenic mechanisms, ability to predict its occurrence, the development of diagnostic tools, prognosis, and treatment. The genetic epidemiology of rheumatoid arthritis is herein reviewed; a set of recommendations is provided for the design, analysis and interpretation of genetic association studies in the context of Latin-American populations.
Idioma originalEnglish (US)
Páginas (desde-hasta)562-584
Número de páginas23
PublicaciónBiomédica : revista del Instituto Nacional de Salud
EstadoPublished - dic 1 2006

Huella dactilar

Molecular Epidemiology
Latin America
Rheumatoid Arthritis
Genetic Predisposition to Disease
Autoimmune Diseases
HLA-DRB1 Chains
Inborn Genetic Diseases
Disease Susceptibility
Genetic Association Studies
Population
Genes
Joints
Alleles
Genome
Inflammation
Therapeutics

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title = "Genetic epidemiology of rheumatoid arthritis: what to expect from Latin America?",
abstract = "Rheumatoid arthritis is a chronic and systemic autoimmune disease characterized by inflammation and destruction of the synovial joints. It affects approximately 0.5{\%} of the Latin-American population and is three times more common in women than in men. Evidence of familial aggregation (lambdas=2-17) was the first indication of a genetic susceptibility to disease. As in other autoimmune diseases, it has a complex genetic basis. Results from whole-genome scans indicate that the HLA region contains a significant and consistent set of linked loci. However, HLA accounts for only one-third of the genetic susceptibility of disease, indicating that non-HLA genes are also involved in the disease susceptibility. In Latin-America, association with HLA-DRB1*0404 and TNF -308A alleles has been uniformly established; however, many other candidate genes remain to be studied. The identification of genetic factors conferring susceptibility to rheumatoid arthritis will contribute to the knowledge of the pathogenic mechanisms, ability to predict its occurrence, the development of diagnostic tools, prognosis, and treatment. The genetic epidemiology of rheumatoid arthritis is herein reviewed; a set of recommendations is provided for the design, analysis and interpretation of genetic association studies in the context of Latin-American populations.",
author = "Delgado-Vega, {Ang{\'e}lica Mar{\'i}a} and Javier Mart{\'i}n and Julio Granados and Anaya, {Juan Manuel}",
year = "2006",
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language = "English (US)",
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Genetic epidemiology of rheumatoid arthritis: what to expect from Latin America? / Delgado-Vega, Angélica María; Martín, Javier; Granados, Julio; Anaya, Juan Manuel.

En: Biomédica : revista del Instituto Nacional de Salud, 01.12.2006, p. 562-584.

Resultado de la investigación: Contribución a RevistaRevisión Literaria

TY - JOUR

T1 - Genetic epidemiology of rheumatoid arthritis: what to expect from Latin America?

AU - Delgado-Vega, Angélica María

AU - Martín, Javier

AU - Granados, Julio

AU - Anaya, Juan Manuel

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Rheumatoid arthritis is a chronic and systemic autoimmune disease characterized by inflammation and destruction of the synovial joints. It affects approximately 0.5% of the Latin-American population and is three times more common in women than in men. Evidence of familial aggregation (lambdas=2-17) was the first indication of a genetic susceptibility to disease. As in other autoimmune diseases, it has a complex genetic basis. Results from whole-genome scans indicate that the HLA region contains a significant and consistent set of linked loci. However, HLA accounts for only one-third of the genetic susceptibility of disease, indicating that non-HLA genes are also involved in the disease susceptibility. In Latin-America, association with HLA-DRB1*0404 and TNF -308A alleles has been uniformly established; however, many other candidate genes remain to be studied. The identification of genetic factors conferring susceptibility to rheumatoid arthritis will contribute to the knowledge of the pathogenic mechanisms, ability to predict its occurrence, the development of diagnostic tools, prognosis, and treatment. The genetic epidemiology of rheumatoid arthritis is herein reviewed; a set of recommendations is provided for the design, analysis and interpretation of genetic association studies in the context of Latin-American populations.

AB - Rheumatoid arthritis is a chronic and systemic autoimmune disease characterized by inflammation and destruction of the synovial joints. It affects approximately 0.5% of the Latin-American population and is three times more common in women than in men. Evidence of familial aggregation (lambdas=2-17) was the first indication of a genetic susceptibility to disease. As in other autoimmune diseases, it has a complex genetic basis. Results from whole-genome scans indicate that the HLA region contains a significant and consistent set of linked loci. However, HLA accounts for only one-third of the genetic susceptibility of disease, indicating that non-HLA genes are also involved in the disease susceptibility. In Latin-America, association with HLA-DRB1*0404 and TNF -308A alleles has been uniformly established; however, many other candidate genes remain to be studied. The identification of genetic factors conferring susceptibility to rheumatoid arthritis will contribute to the knowledge of the pathogenic mechanisms, ability to predict its occurrence, the development of diagnostic tools, prognosis, and treatment. The genetic epidemiology of rheumatoid arthritis is herein reviewed; a set of recommendations is provided for the design, analysis and interpretation of genetic association studies in the context of Latin-American populations.

M3 - Literature review

SP - 562

EP - 584

JO - Biomedica

JF - Biomedica

SN - 0120-4157

ER -