Genetic Diversity and Selection in Three Plasmodium vivax Merozoite Surface Protein 7 (Pvmsp-7) Genes in a Colombian Population

Diego Garzón-Ospina, Carolina López, Johanna Forero-Rodríguez, Manuel A. Patarroyo

Resultado de la investigación: Contribución a RevistaArtículo

14 Citas (Scopus)

Resumen

A completely effective vaccine for malaria (one of the major infectious diseases worldwide) is not yet available; different membrane proteins involved in parasite-host interactions have been proposed as candidates for designing it. It has been found that proteins encoded by the merozoite surface protein (msp)-7 multigene family are antibody targets in natural infection; the nucleotide diversity of three Pvmsp-7 genes was thus analyzed in a Colombian parasite population. By contrast with P. falciparum msp-7 loci and ancestral P. vivax msp-7 genes, specie-specific duplicates of the latter specie display high genetic variability, generated by single nucleotide polymorphisms, repeat regions, and recombination. At least three major allele types are present in Pvmsp-7C, Pvmsp-7H and Pvmsp-7I and positive selection seems to be operating on the central region of these msp-7 genes. Although this region has high genetic polymorphism, the C-terminus (Pfam domain ID: PF12948) is conserved and could be an important candidate when designing a subunit-based antimalarial vaccine. © 2012 Garzon-Ospina et al.
Idioma originalEnglish (US)
PublicaciónPLoS One
DOI
EstadoPublished - sep 25 2012

Huella dactilar

Plasmodium vivax
merozoites
Genetic Selection
surface proteins
Merozoites
Membrane Proteins
Genes
genetic variation
Population
genes
Malaria Vaccines
Polymorphism
Host-Parasite Interactions
Antimalarials
Genetic Polymorphisms
Nucleotides
Multigene Family
antimalarials
Genetic Recombination
host-parasite relationships

Citar esto

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title = "Genetic Diversity and Selection in Three Plasmodium vivax Merozoite Surface Protein 7 (Pvmsp-7) Genes in a Colombian Population",
abstract = "A completely effective vaccine for malaria (one of the major infectious diseases worldwide) is not yet available; different membrane proteins involved in parasite-host interactions have been proposed as candidates for designing it. It has been found that proteins encoded by the merozoite surface protein (msp)-7 multigene family are antibody targets in natural infection; the nucleotide diversity of three Pvmsp-7 genes was thus analyzed in a Colombian parasite population. By contrast with P. falciparum msp-7 loci and ancestral P. vivax msp-7 genes, specie-specific duplicates of the latter specie display high genetic variability, generated by single nucleotide polymorphisms, repeat regions, and recombination. At least three major allele types are present in Pvmsp-7C, Pvmsp-7H and Pvmsp-7I and positive selection seems to be operating on the central region of these msp-7 genes. Although this region has high genetic polymorphism, the C-terminus (Pfam domain ID: PF12948) is conserved and could be an important candidate when designing a subunit-based antimalarial vaccine. {\circledC} 2012 Garzon-Ospina et al.",
author = "Diego Garz{\'o}n-Ospina and Carolina L{\'o}pez and Johanna Forero-Rodr{\'i}guez and Patarroyo, {Manuel A.}",
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Genetic Diversity and Selection in Three Plasmodium vivax Merozoite Surface Protein 7 (Pvmsp-7) Genes in a Colombian Population. / Garzón-Ospina, Diego; López, Carolina; Forero-Rodríguez, Johanna; Patarroyo, Manuel A.

En: PLoS One, 25.09.2012.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Genetic Diversity and Selection in Three Plasmodium vivax Merozoite Surface Protein 7 (Pvmsp-7) Genes in a Colombian Population

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AU - López, Carolina

AU - Forero-Rodríguez, Johanna

AU - Patarroyo, Manuel A.

PY - 2012/9/25

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AB - A completely effective vaccine for malaria (one of the major infectious diseases worldwide) is not yet available; different membrane proteins involved in parasite-host interactions have been proposed as candidates for designing it. It has been found that proteins encoded by the merozoite surface protein (msp)-7 multigene family are antibody targets in natural infection; the nucleotide diversity of three Pvmsp-7 genes was thus analyzed in a Colombian parasite population. By contrast with P. falciparum msp-7 loci and ancestral P. vivax msp-7 genes, specie-specific duplicates of the latter specie display high genetic variability, generated by single nucleotide polymorphisms, repeat regions, and recombination. At least three major allele types are present in Pvmsp-7C, Pvmsp-7H and Pvmsp-7I and positive selection seems to be operating on the central region of these msp-7 genes. Although this region has high genetic polymorphism, the C-terminus (Pfam domain ID: PF12948) is conserved and could be an important candidate when designing a subunit-based antimalarial vaccine. © 2012 Garzon-Ospina et al.

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