Genetic and molecular aspects of drug-induced QT interval prolongation

Daniela Baracaldo-Santamaría; Kevin Llinás-Caballero; Julián Miguel Corso-Ramirez; Carlos Martín Restrepo; Camilo Alberto Dominguez-Dominguez; Dora Janeth Fonseca-Mendoza; Carlos Alberto Calderon - Ospina

doi:10.3390/ijms22158090

Genetic and molecular aspects of drug-induced QT interval prolongation

Título traducido de la contribución: Aspectos genéticos y moleculares de la prolongación del intervalo QT inducida por fármacos

Daniela Baracaldo-Santamaría, Kevin Llinás-Caballero, Julián Miguel Corso-Ramirez, Carlos Martín Restrepo, Camilo Alberto Dominguez-Dominguez, Dora Janeth Fonseca-Mendoza, Carlos Alberto Calderon - Ospina

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

17 Citas (Scopus)

20 Descargas (Pure)

Resumen

Los síndromes de QT largo pueden ser adquiridos o congénitos. Los fármacos son una de las muchas etiologías que pueden inducir el síndrome de QT largo adquirido. De hecho, muchos fármacos utilizados con frecuencia en el entorno clínico son un factor de riesgo conocido para un intervalo QT prolongado, lo que aumenta las posibilidades de desarrollar torsade de pointes. Los mecanismos moleculares implicados en la prolongación del intervalo QT son comunes a la mayoría de los medicamentos. Sin embargo, existe una gran variabilidad interindividual en la respuesta al fármaco, por lo que la aplicación de la medicina personalizada es un aspecto relevante en el síndrome de QT largo, con el fin de evaluar el riesgo de cada individuo desde un punto de vista farmacogenético.

Título traducido de la contribución	Aspectos genéticos y moleculares de la prolongación del intervalo QT inducida por fármacos
Idioma original	Inglés estadounidense
Número de artículo	8090
Publicación	International Journal of Molecular Sciences
Volumen	22
N.º	15
DOI	https://doi.org/10.3390/ijms22158090
Estado	Publicada - jul. 28 2021

Áreas temáticas de ASJC Scopus

Catálisis
Biología molecular
Espectroscopia
Informática aplicada
Química física y teórica
Química orgánica
Química inorgánica

Acceder al documento

10.3390/ijms22158090

ijms-22-08090-v4(5)Licencia: CC BY

Otros archivos y enlaces

Citar esto

@article{9b15eaeb2a3c4f0080a2f575173cbc99,

title = "Genetic and molecular aspects of drug-induced QT interval prolongation",

abstract = "Long QT syndromes can be either acquired or congenital. Drugs are one of the many etiologies that may induce acquired long QT syndrome. In fact, many drugs frequently used in the clinical setting are a known risk factor for a prolonged QT interval, thus increasing the chances of developing torsade de pointes. The molecular mechanisms involved in the prolongation of the QT interval are common to most medications. However, there is considerable inter-individual variability in drug response, thus making the application of personalized medicine a relevant aspect in long QT syndrome, in order to evaluate the risk of every individual from a pharmacogenetic standpoint.",

author = "Daniela Baracaldo-Santamar{\'i}a and Kevin Llin{\'a}s-Caballero and Corso-Ramirez, {Juli{\'a}n Miguel} and Restrepo, {Carlos Mart{\'i}n} and Dominguez-Dominguez, {Camilo Alberto} and Fonseca-Mendoza, {Dora Janeth} and {Calderon - Ospina}, {Carlos Alberto}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors.",

year = "2021",

month = jul,

day = "28",

doi = "10.3390/ijms22158090",

language = "English (US)",

volume = "22",

journal = "International Journal of Molecular Sciences",

issn = "1661-6596",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "15",

}

TY - JOUR

T1 - Genetic and molecular aspects of drug-induced QT interval prolongation

AU - Baracaldo-Santamaría, Daniela

AU - Llinás-Caballero, Kevin

AU - Corso-Ramirez, Julián Miguel

AU - Restrepo, Carlos Martín

AU - Dominguez-Dominguez, Camilo Alberto

AU - Fonseca-Mendoza, Dora Janeth

AU - Calderon - Ospina, Carlos Alberto

PY - 2021/7/28

Y1 - 2021/7/28

N2 - Long QT syndromes can be either acquired or congenital. Drugs are one of the many etiologies that may induce acquired long QT syndrome. In fact, many drugs frequently used in the clinical setting are a known risk factor for a prolonged QT interval, thus increasing the chances of developing torsade de pointes. The molecular mechanisms involved in the prolongation of the QT interval are common to most medications. However, there is considerable inter-individual variability in drug response, thus making the application of personalized medicine a relevant aspect in long QT syndrome, in order to evaluate the risk of every individual from a pharmacogenetic standpoint.

AB - Long QT syndromes can be either acquired or congenital. Drugs are one of the many etiologies that may induce acquired long QT syndrome. In fact, many drugs frequently used in the clinical setting are a known risk factor for a prolonged QT interval, thus increasing the chances of developing torsade de pointes. The molecular mechanisms involved in the prolongation of the QT interval are common to most medications. However, there is considerable inter-individual variability in drug response, thus making the application of personalized medicine a relevant aspect in long QT syndrome, in order to evaluate the risk of every individual from a pharmacogenetic standpoint.

UR - http://www.scopus.com/inward/record.url?scp=85111630317&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85111630317&partnerID=8YFLogxK

UR - https://www.mdpi.com/1422-0067/22/15/8090

U2 - 10.3390/ijms22158090

DO - 10.3390/ijms22158090

M3 - Review article

C2 - 34360853

AN - SCOPUS:85111630317

SN - 1661-6596

VL - 22

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 15

M1 - 8090

ER -

Genetic and molecular aspects of drug-induced QT interval prolongation

Resumen

Áreas temáticas de ASJC Scopus

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto