GDF15(MIC1) H6D Polymorphism Does Not Influence Cardiovascular Disease in a Latin American Population with Rheumatoid Arthritis

Jenny Amaya-Amaya, Adriana Rojas-Villarraga, Nicolas Molano-Gonzalez, Laura Montoya-Sánchez, Swapan K. Nath, Juan Manuel Anaya

Resultado de la investigación: Contribución a RevistaArtículo

3 Citas (Scopus)

Resumen

Copyright © 2015 Jenny Amaya-Amaya et al.Objective. Rheumatoid arthritis (RA) is the most common autoimmune arthropathy worldwide. The increased prevalence of cardiovascular disease (CVD) in RA is not fully explained by classic risk factors. The aim of this study was to determine the influence of rs1058587 SNP within GDF15(MIC1) gene on the risk of CVD in a Colombian RA population. Methods. This was a cross-sectional analytical study in which 310 consecutive Colombian patients with RA and 228 age- and sex-matched controls were included and assessed for variables associated with CVD. The mixed cluster methodology based on multivariate descriptive methods such as principal components analysis and multiple correspondence analyses and regression tree (CART) predictive model were performed. Results. Of the 310 patients, 87.4% were women and CVD was reported in 69.5%. Significant differences concerning GDF15 polymorphism were not observed between patients and controls. Mean arterial pressure, current smoking, and some clusters were significantly associated with CVD. Conclusion. GDF15 (rs1058587) does not influence the development of CVD in the population studied.
Idioma originalEnglish (US)
PublicaciónJournal of Immunology Research
DOI
EstadoPublished - ene 1 2015

Huella dactilar

Rheumatoid Arthritis
Cardiovascular Diseases
Population
Joint Diseases
Principal Component Analysis
Single Nucleotide Polymorphism
Arterial Pressure
Cross-Sectional Studies
Smoking
Regression Analysis
Genes

Citar esto

Amaya-Amaya, Jenny ; Rojas-Villarraga, Adriana ; Molano-Gonzalez, Nicolas ; Montoya-Sánchez, Laura ; Nath, Swapan K. ; Anaya, Juan Manuel. / GDF15(MIC1) H6D Polymorphism Does Not Influence Cardiovascular Disease in a Latin American Population with Rheumatoid Arthritis. En: Journal of Immunology Research. 2015.
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title = "GDF15(MIC1) H6D Polymorphism Does Not Influence Cardiovascular Disease in a Latin American Population with Rheumatoid Arthritis",
abstract = "Copyright {\circledC} 2015 Jenny Amaya-Amaya et al.Objective. Rheumatoid arthritis (RA) is the most common autoimmune arthropathy worldwide. The increased prevalence of cardiovascular disease (CVD) in RA is not fully explained by classic risk factors. The aim of this study was to determine the influence of rs1058587 SNP within GDF15(MIC1) gene on the risk of CVD in a Colombian RA population. Methods. This was a cross-sectional analytical study in which 310 consecutive Colombian patients with RA and 228 age- and sex-matched controls were included and assessed for variables associated with CVD. The mixed cluster methodology based on multivariate descriptive methods such as principal components analysis and multiple correspondence analyses and regression tree (CART) predictive model were performed. Results. Of the 310 patients, 87.4{\%} were women and CVD was reported in 69.5{\%}. Significant differences concerning GDF15 polymorphism were not observed between patients and controls. Mean arterial pressure, current smoking, and some clusters were significantly associated with CVD. Conclusion. GDF15 (rs1058587) does not influence the development of CVD in the population studied.",
author = "Jenny Amaya-Amaya and Adriana Rojas-Villarraga and Nicolas Molano-Gonzalez and Laura Montoya-S{\'a}nchez and Nath, {Swapan K.} and Anaya, {Juan Manuel}",
year = "2015",
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doi = "10.1155/2015/270763",
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journal = "Journal of Immunology Research",
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GDF15(MIC1) H6D Polymorphism Does Not Influence Cardiovascular Disease in a Latin American Population with Rheumatoid Arthritis. / Amaya-Amaya, Jenny; Rojas-Villarraga, Adriana; Molano-Gonzalez, Nicolas; Montoya-Sánchez, Laura; Nath, Swapan K.; Anaya, Juan Manuel.

En: Journal of Immunology Research, 01.01.2015.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - GDF15(MIC1) H6D Polymorphism Does Not Influence Cardiovascular Disease in a Latin American Population with Rheumatoid Arthritis

AU - Amaya-Amaya, Jenny

AU - Rojas-Villarraga, Adriana

AU - Molano-Gonzalez, Nicolas

AU - Montoya-Sánchez, Laura

AU - Nath, Swapan K.

AU - Anaya, Juan Manuel

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Copyright © 2015 Jenny Amaya-Amaya et al.Objective. Rheumatoid arthritis (RA) is the most common autoimmune arthropathy worldwide. The increased prevalence of cardiovascular disease (CVD) in RA is not fully explained by classic risk factors. The aim of this study was to determine the influence of rs1058587 SNP within GDF15(MIC1) gene on the risk of CVD in a Colombian RA population. Methods. This was a cross-sectional analytical study in which 310 consecutive Colombian patients with RA and 228 age- and sex-matched controls were included and assessed for variables associated with CVD. The mixed cluster methodology based on multivariate descriptive methods such as principal components analysis and multiple correspondence analyses and regression tree (CART) predictive model were performed. Results. Of the 310 patients, 87.4% were women and CVD was reported in 69.5%. Significant differences concerning GDF15 polymorphism were not observed between patients and controls. Mean arterial pressure, current smoking, and some clusters were significantly associated with CVD. Conclusion. GDF15 (rs1058587) does not influence the development of CVD in the population studied.

AB - Copyright © 2015 Jenny Amaya-Amaya et al.Objective. Rheumatoid arthritis (RA) is the most common autoimmune arthropathy worldwide. The increased prevalence of cardiovascular disease (CVD) in RA is not fully explained by classic risk factors. The aim of this study was to determine the influence of rs1058587 SNP within GDF15(MIC1) gene on the risk of CVD in a Colombian RA population. Methods. This was a cross-sectional analytical study in which 310 consecutive Colombian patients with RA and 228 age- and sex-matched controls were included and assessed for variables associated with CVD. The mixed cluster methodology based on multivariate descriptive methods such as principal components analysis and multiple correspondence analyses and regression tree (CART) predictive model were performed. Results. Of the 310 patients, 87.4% were women and CVD was reported in 69.5%. Significant differences concerning GDF15 polymorphism were not observed between patients and controls. Mean arterial pressure, current smoking, and some clusters were significantly associated with CVD. Conclusion. GDF15 (rs1058587) does not influence the development of CVD in the population studied.

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JO - Journal of Immunology Research

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