Gastrointestinal-associated autoantibodies in different autoimmune diseases

Dana Ben Ami Shor; Hedi Orbach; Mona Boaz; Arie Altman; Juan-Manuel Anaya; Nicola Bizzaro; Angela Tincani; Ricard Cervera; Gerard Espinosa; Ljudmila Stojanovich; Blaž Rozman; Stefano Bombardieri; Salvatore De Vita; Jan Damoiseaux; Danilo Villalta; Elio Tonutti; Renato Tozzoli; Ori Barzilai; Maya Ram; Miri Blank; Nancy Agmon-Levin; Yehuda Shoenfeld

Gastrointestinal-associated autoantibodies in different autoimmune diseases

Dana Ben Ami Shor, Hedi Orbach, Mona Boaz, Arie Altman, Juan-Manuel Anaya, Nicola Bizzaro, Angela Tincani, Ricard Cervera, Gerard Espinosa, Ljudmila Stojanovich, Blaž Rozman, Stefano Bombardieri, Salvatore De Vita, Jan Damoiseaux, Danilo Villalta, Elio Tonutti, Renato Tozzoli, Ori Barzilai, Maya Ram, Miri BlankNancy Agmon-Levin, Yehuda Shoenfeld

Centro de Estudio de Enfermedades Autoinmunes (CREA)

Resultado de la investigación: Contribución a una revista › Artículo › revisión exhaustiva

Resumen

BACKGROUND: Gastrointestinal (GI)-related autoantibodies (Abs) are rarely evaluated in autoimmune diseases (AID) other than inflammatory bowel disease, autoimmune hepatitis and celiac disease. Our aim was to determine the prevalence of these antibodies in a wide spectrum of AID.

METHODS: We examined 923 serum samples representing 18 AID and compared them with 338 samples from healthy subjects. We used the BioPlex 2200-immunoassay (Bio-Rad, USA) to test samples for the presence of IgA and IgG directed at gliadin (AGA), tissue-transglutaminase (tTG), and Saccharomyces cerevisiae (ASCA).

RESULTS: Prevalence of IgA AGA was significantly higher in antiphospholipid syndrome (APS) (7.1 %, P=0.012) and in pemphigus vulgaris (25%, P =0.008) patients, as compared with healthy controls. Presence of IgG-AGA was more common among Crohn's disease (20.5%, P = 0.023) and rheumatoid arthritis (6.5%, P=0.027) patients. IgG anti tTG were frequently observed in APS (6.1%, P=0.012), in giant cell arteritis (11.5%, P=0.013) and in ulcerative colitis (11.1%, P=0.018) patients, and as expected, higher prevalence of ASCA (IgA 19.3% and IgG 27.7%) was found in Crohn's disease. IgG ASCA were also found in systemic lupus erythematosus (SLE) (4.5%, P=0.01), in Graves' disease (5.7%, P=0.018), in cryoglobulinemia (7.1%, P=0.006), and in patients with vasculitides (6.5%, P=0.002). In contrast, lower prevalence of IgG type AGA was found in SLE (P=0.034), cryoglobulinemia (P=0.019) and vasculitides (P=0.013) patients.

CONCLUSIONS: Our findings suggest an association between GI-related- Abs and a wide spectrum of AID. The clinical implication of these findings is yet to be determined.

Idioma original	Inglés estadounidense
Páginas (desde-hasta)	49-55
Número de páginas	7
Publicación	American journal of clinical and experimental immunology
Volumen	1
N.º	1
Estado	Publicada - 2012

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Shor, D. B. A., Orbach, H., Boaz, M., Altman, A., Anaya, J-M., Bizzaro, N., Tincani, A., Cervera, R., Espinosa, G., Stojanovich, L., Rozman, B., Bombardieri, S., De Vita, S., Damoiseaux, J., Villalta, D., Tonutti, E., Tozzoli, R., Barzilai, O., Ram, M., ... Shoenfeld, Y. (2012). Gastrointestinal-associated autoantibodies in different autoimmune diseases. American journal of clinical and experimental immunology, 1(1), 49-55.

@article{8230a64300234b0d91e670abde52a8cd,

title = "Gastrointestinal-associated autoantibodies in different autoimmune diseases",

abstract = "BACKGROUND: Gastrointestinal (GI)-related autoantibodies (Abs) are rarely evaluated in autoimmune diseases (AID) other than inflammatory bowel disease, autoimmune hepatitis and celiac disease. Our aim was to determine the prevalence of these antibodies in a wide spectrum of AID.METHODS: We examined 923 serum samples representing 18 AID and compared them with 338 samples from healthy subjects. We used the BioPlex 2200-immunoassay (Bio-Rad, USA) to test samples for the presence of IgA and IgG directed at gliadin (AGA), tissue-transglutaminase (tTG), and Saccharomyces cerevisiae (ASCA).RESULTS: Prevalence of IgA AGA was significantly higher in antiphospholipid syndrome (APS) (7.1 %, P=0.012) and in pemphigus vulgaris (25%, P =0.008) patients, as compared with healthy controls. Presence of IgG-AGA was more common among Crohn's disease (20.5%, P = 0.023) and rheumatoid arthritis (6.5%, P=0.027) patients. IgG anti tTG were frequently observed in APS (6.1%, P=0.012), in giant cell arteritis (11.5%, P=0.013) and in ulcerative colitis (11.1%, P=0.018) patients, and as expected, higher prevalence of ASCA (IgA 19.3% and IgG 27.7%) was found in Crohn's disease. IgG ASCA were also found in systemic lupus erythematosus (SLE) (4.5%, P=0.01), in Graves' disease (5.7%, P=0.018), in cryoglobulinemia (7.1%, P=0.006), and in patients with vasculitides (6.5%, P=0.002). In contrast, lower prevalence of IgG type AGA was found in SLE (P=0.034), cryoglobulinemia (P=0.019) and vasculitides (P=0.013) patients.CONCLUSIONS: Our findings suggest an association between GI-related- Abs and a wide spectrum of AID. The clinical implication of these findings is yet to be determined.",

author = "Shor, {Dana Ben Ami} and Hedi Orbach and Mona Boaz and Arie Altman and Juan-Manuel Anaya and Nicola Bizzaro and Angela Tincani and Ricard Cervera and Gerard Espinosa and Ljudmila Stojanovich and Bla{\v z} Rozman and Stefano Bombardieri and {De Vita}, Salvatore and Jan Damoiseaux and Danilo Villalta and Elio Tonutti and Renato Tozzoli and Ori Barzilai and Maya Ram and Miri Blank and Nancy Agmon-Levin and Yehuda Shoenfeld",

year = "2012",

language = "English (US)",

volume = "1",

pages = "49--55",

journal = "American Journal of Clinical and Experimental Immunology",

issn = "2164-7712",

publisher = "e-Century Publishing Corporation",

number = "1",

}

Shor, DBA, Orbach, H, Boaz, M, Altman, A, Anaya, J-M, Bizzaro, N, Tincani, A, Cervera, R, Espinosa, G, Stojanovich, L, Rozman, B, Bombardieri, S, De Vita, S, Damoiseaux, J, Villalta, D, Tonutti, E, Tozzoli, R, Barzilai, O, Ram, M, Blank, M, Agmon-Levin, N & Shoenfeld, Y 2012, 'Gastrointestinal-associated autoantibodies in different autoimmune diseases', American journal of clinical and experimental immunology, vol. 1, n.º 1, pp. 49-55.

TY - JOUR

T1 - Gastrointestinal-associated autoantibodies in different autoimmune diseases

AU - Shor, Dana Ben Ami

AU - Orbach, Hedi

AU - Boaz, Mona

AU - Altman, Arie

AU - Anaya, Juan-Manuel

AU - Bizzaro, Nicola

AU - Tincani, Angela

AU - Cervera, Ricard

AU - Espinosa, Gerard

AU - Stojanovich, Ljudmila

AU - Rozman, Blaž

AU - Bombardieri, Stefano

AU - De Vita, Salvatore

AU - Damoiseaux, Jan

AU - Villalta, Danilo

AU - Tonutti, Elio

AU - Tozzoli, Renato

AU - Barzilai, Ori

AU - Ram, Maya

AU - Blank, Miri

AU - Agmon-Levin, Nancy

AU - Shoenfeld, Yehuda

PY - 2012

Y1 - 2012

N2 - BACKGROUND: Gastrointestinal (GI)-related autoantibodies (Abs) are rarely evaluated in autoimmune diseases (AID) other than inflammatory bowel disease, autoimmune hepatitis and celiac disease. Our aim was to determine the prevalence of these antibodies in a wide spectrum of AID.METHODS: We examined 923 serum samples representing 18 AID and compared them with 338 samples from healthy subjects. We used the BioPlex 2200-immunoassay (Bio-Rad, USA) to test samples for the presence of IgA and IgG directed at gliadin (AGA), tissue-transglutaminase (tTG), and Saccharomyces cerevisiae (ASCA).RESULTS: Prevalence of IgA AGA was significantly higher in antiphospholipid syndrome (APS) (7.1 %, P=0.012) and in pemphigus vulgaris (25%, P =0.008) patients, as compared with healthy controls. Presence of IgG-AGA was more common among Crohn's disease (20.5%, P = 0.023) and rheumatoid arthritis (6.5%, P=0.027) patients. IgG anti tTG were frequently observed in APS (6.1%, P=0.012), in giant cell arteritis (11.5%, P=0.013) and in ulcerative colitis (11.1%, P=0.018) patients, and as expected, higher prevalence of ASCA (IgA 19.3% and IgG 27.7%) was found in Crohn's disease. IgG ASCA were also found in systemic lupus erythematosus (SLE) (4.5%, P=0.01), in Graves' disease (5.7%, P=0.018), in cryoglobulinemia (7.1%, P=0.006), and in patients with vasculitides (6.5%, P=0.002). In contrast, lower prevalence of IgG type AGA was found in SLE (P=0.034), cryoglobulinemia (P=0.019) and vasculitides (P=0.013) patients.CONCLUSIONS: Our findings suggest an association between GI-related- Abs and a wide spectrum of AID. The clinical implication of these findings is yet to be determined.

AB - BACKGROUND: Gastrointestinal (GI)-related autoantibodies (Abs) are rarely evaluated in autoimmune diseases (AID) other than inflammatory bowel disease, autoimmune hepatitis and celiac disease. Our aim was to determine the prevalence of these antibodies in a wide spectrum of AID.METHODS: We examined 923 serum samples representing 18 AID and compared them with 338 samples from healthy subjects. We used the BioPlex 2200-immunoassay (Bio-Rad, USA) to test samples for the presence of IgA and IgG directed at gliadin (AGA), tissue-transglutaminase (tTG), and Saccharomyces cerevisiae (ASCA).RESULTS: Prevalence of IgA AGA was significantly higher in antiphospholipid syndrome (APS) (7.1 %, P=0.012) and in pemphigus vulgaris (25%, P =0.008) patients, as compared with healthy controls. Presence of IgG-AGA was more common among Crohn's disease (20.5%, P = 0.023) and rheumatoid arthritis (6.5%, P=0.027) patients. IgG anti tTG were frequently observed in APS (6.1%, P=0.012), in giant cell arteritis (11.5%, P=0.013) and in ulcerative colitis (11.1%, P=0.018) patients, and as expected, higher prevalence of ASCA (IgA 19.3% and IgG 27.7%) was found in Crohn's disease. IgG ASCA were also found in systemic lupus erythematosus (SLE) (4.5%, P=0.01), in Graves' disease (5.7%, P=0.018), in cryoglobulinemia (7.1%, P=0.006), and in patients with vasculitides (6.5%, P=0.002). In contrast, lower prevalence of IgG type AGA was found in SLE (P=0.034), cryoglobulinemia (P=0.019) and vasculitides (P=0.013) patients.CONCLUSIONS: Our findings suggest an association between GI-related- Abs and a wide spectrum of AID. The clinical implication of these findings is yet to be determined.

M3 - Article

C2 - 23885314

SN - 2164-7712

VL - 1

SP - 49

EP - 55

JO - American Journal of Clinical and Experimental Immunology

JF - American Journal of Clinical and Experimental Immunology

IS - 1

ER -

Gastrointestinal-associated autoantibodies in different autoimmune diseases

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