Fluctuations in Craving and Mood State Bias Subjective Valuation in Addiction

John Messinger, Silvia Lopez-Guzman, Nidhi Banavar, John Rotrosen, Paul Glimcher, Anna Konova

Resultado de la investigación: Contribución a RevistaResumen en Conferencia

Resumen

Antecedentes: Cómo se manifiestan el antojo y el estado de ánimo (por ejemplo, estrés, aburrimiento) comportamiento sesgado hacia lo gratificante pero menos adaptativas alternativas y lejos de las metas de salud de un individuo es mal entendido, sin embargo, juegan un papel crítico en la adicción y la desórdenes alimenticios. Aquí probamos la hipótesis de que este sesgo es un aumento dependiente del estado en el valor subjetivo de estas gratificantes pero menos adaptables alternativas de elección. Métodos: 27 usuarios de opiáceos en busca de tratamiento completaron un tarea de toma de decisiones que sondeó su disposición momentánea a pagar para una gama de productos reales relacionados con el uso de opiáceos y los bienes no relacionados, una medida cuantitativa de su valor. Estos bienes se identificaron como los más (menos) relacionados con un el uso individual de cada sujeto. Para capturar cómo la dinámica en el deseo espontáneo de consumir opiáceos y el estado de ánimo afectan a la subjetividad valoración, los pacientes completaron la tarea en 2 días mientras informando continuamente de su ansia actual de opiáceos, el estrés nivel, aburrimiento y felicidad. Conductividad cutánea y facial El EMG se midió al mismo tiempo como índices de excitación y valencia, respectivamente. Resultados: Los sujetos estaban dispuestos a pagar más específicamente por productos personalizados relacionados con los opiáceos cuando se experimenta una mayor el ansia, el estrés, el aburrimiento y la felicidad inferior (subjetivo nivel estatal X de relación con los opiáceos: P<0.016). A pesar de que la correlación entre los estados subjetivos (R¼j.14e0.51j), el los efectos de cada uno de ellos sobre la valoración fueron en gran medida independientes, particularmente de antojo y estrés. Análisis de las características fisiológicas los datos están en curso, pero suponemos que estos datos servirán como medidas auxiliares y objetivas de cómo el sesgo de los estados subjetivos valoración. Conclusiones: Estos datos sugieren que el ansia y el estrés tanto mejorar el valor de las alternativas de elección menos adaptables cuando son inmediatamente gratificantes, reflejando potencialmente una mecanismo compensatorio destinado a amortiguar estos estados.
Idioma originalEnglish (US)
Páginas (desde-hasta)S232-S233
PublicaciónBiological Psychiatry
Volumen83
N.º9
DOI
EstadoPublished - may 1 2018

Citar esto

Messinger, John ; Lopez-Guzman, Silvia ; Banavar, Nidhi ; Rotrosen, John ; Glimcher, Paul ; Konova, Anna. / Fluctuations in Craving and Mood State Bias Subjective Valuation in Addiction. En: Biological Psychiatry. 2018 ; Vol. 83, N.º 9. pp. S232-S233.
@article{3e8307c49e9241db9aad1cbadef05016,
title = "Fluctuations in Craving and Mood State Bias Subjective Valuation in Addiction",
abstract = "Background: How craving and mood states (e.g., stress, boredom) bias behavior toward rewarding but less adaptive alternatives and away from an individual’s health goals is poorly understood, yet play a critical role in addiction and eating disorders. Here we test the hypothesis that underlying this bias is a state-dependent increase in the subjective value of these rewarding but less-adaptive choice alternatives. Methods: 27 treatment-seeking opioid users completed a decision-making task that probed their momentary willingness-to-pay for a range of real opioid useerelated and eunrelated goods, a quantitative measure of their value. These goods were identified as most (least) related to an individual subject’s use. To capture how dynamics in spontaneous opioid craving and mood affect subjective valuation, patients completed the task over 2 days while continuously reporting their current opioid craving, stress level, boredom, and happiness. Skin conductance and facial EMG were measured concurrently as indices of arousal and valence, respectively. Results: Subjects were willing to pay more specifically for personalized opioid-related goods when experiencing higher craving, stress, and boredom and lower happiness (subjective state level X opioid-relatedness: P<0.016). Despite mild correlation across subjective states (R¼j0.14e0.51j), the effects of each on valuation were largely independent, particularly of craving and stress. Analysis of physiological data is ongoing, but we hypothesize these data will serve as auxiliary, objective measures of how subjective states bias valuation. Conclusions: These data suggest craving and stress both enhance the value of less-adaptive choice alternatives when these are immediately rewarding, potentially reflecting a compensatory mechanism aimed at buffering these states",
author = "John Messinger and Silvia Lopez-Guzman and Nidhi Banavar and John Rotrosen and Paul Glimcher and Anna Konova",
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Fluctuations in Craving and Mood State Bias Subjective Valuation in Addiction. / Messinger, John; Lopez-Guzman, Silvia; Banavar, Nidhi; Rotrosen, John; Glimcher, Paul; Konova, Anna.

En: Biological Psychiatry, Vol. 83, N.º 9, 01.05.2018, p. S232-S233.

Resultado de la investigación: Contribución a RevistaResumen en Conferencia

TY - JOUR

T1 - Fluctuations in Craving and Mood State Bias Subjective Valuation in Addiction

AU - Messinger, John

AU - Lopez-Guzman, Silvia

AU - Banavar, Nidhi

AU - Rotrosen, John

AU - Glimcher, Paul

AU - Konova, Anna

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Background: How craving and mood states (e.g., stress, boredom) bias behavior toward rewarding but less adaptive alternatives and away from an individual’s health goals is poorly understood, yet play a critical role in addiction and eating disorders. Here we test the hypothesis that underlying this bias is a state-dependent increase in the subjective value of these rewarding but less-adaptive choice alternatives. Methods: 27 treatment-seeking opioid users completed a decision-making task that probed their momentary willingness-to-pay for a range of real opioid useerelated and eunrelated goods, a quantitative measure of their value. These goods were identified as most (least) related to an individual subject’s use. To capture how dynamics in spontaneous opioid craving and mood affect subjective valuation, patients completed the task over 2 days while continuously reporting their current opioid craving, stress level, boredom, and happiness. Skin conductance and facial EMG were measured concurrently as indices of arousal and valence, respectively. Results: Subjects were willing to pay more specifically for personalized opioid-related goods when experiencing higher craving, stress, and boredom and lower happiness (subjective state level X opioid-relatedness: P<0.016). Despite mild correlation across subjective states (R¼j0.14e0.51j), the effects of each on valuation were largely independent, particularly of craving and stress. Analysis of physiological data is ongoing, but we hypothesize these data will serve as auxiliary, objective measures of how subjective states bias valuation. Conclusions: These data suggest craving and stress both enhance the value of less-adaptive choice alternatives when these are immediately rewarding, potentially reflecting a compensatory mechanism aimed at buffering these states

AB - Background: How craving and mood states (e.g., stress, boredom) bias behavior toward rewarding but less adaptive alternatives and away from an individual’s health goals is poorly understood, yet play a critical role in addiction and eating disorders. Here we test the hypothesis that underlying this bias is a state-dependent increase in the subjective value of these rewarding but less-adaptive choice alternatives. Methods: 27 treatment-seeking opioid users completed a decision-making task that probed their momentary willingness-to-pay for a range of real opioid useerelated and eunrelated goods, a quantitative measure of their value. These goods were identified as most (least) related to an individual subject’s use. To capture how dynamics in spontaneous opioid craving and mood affect subjective valuation, patients completed the task over 2 days while continuously reporting their current opioid craving, stress level, boredom, and happiness. Skin conductance and facial EMG were measured concurrently as indices of arousal and valence, respectively. Results: Subjects were willing to pay more specifically for personalized opioid-related goods when experiencing higher craving, stress, and boredom and lower happiness (subjective state level X opioid-relatedness: P<0.016). Despite mild correlation across subjective states (R¼j0.14e0.51j), the effects of each on valuation were largely independent, particularly of craving and stress. Analysis of physiological data is ongoing, but we hypothesize these data will serve as auxiliary, objective measures of how subjective states bias valuation. Conclusions: These data suggest craving and stress both enhance the value of less-adaptive choice alternatives when these are immediately rewarding, potentially reflecting a compensatory mechanism aimed at buffering these states

U2 - https://doi.org/10.1016/j.biopsych.2018.02.602

DO - https://doi.org/10.1016/j.biopsych.2018.02.602

M3 - Meeting Abstract

VL - 83

SP - S232-S233

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 9

ER -