Fine mapping of Xq28: Both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups

Kenneth M. Kaufman, Jian Zhao, Jennifer A. Kelly, Travis Hughes, Adam Adler, Elena Sanchez, Joshua O. Ojwang, Carl D. Langefeld, Julie T. Ziegler, Adrienne H. Williams, Mary E. Comeau, Miranda C. Marion, Stuart B. Glenn, Rita M. Cantor, Jennifer M. Grossman, Bevra H. Hahn, Yeong Wook Song, Chack Yung Yu, Judith A. James, Joel M. Guthridge & 30 otros Elizabeth E. Brown, Graciela S. Alarcón, Robert P. Kimberly, Jeffrey C. Edberg, Rosalind Ramsey-Goldman, Michelle A. Petri, John D. Reveille, Luis M. Vilá, Juan Manuel Anaya, Susan A. Boackle, Anne M. Stevens, Barry I. Freedman, Lindsey A. Criswell, Bernardo A. Pons-Este, Joo Hyun Lee, Ji Seon Lee, Deh Ming Chang, R. Hal A Scofield, Gary S. Gilkeson, Joan T. Merrill, Timothy B. Niewold, Timothy James Vyse, Sang Cheol Bae, Marta E. Alarcón-Riquelme, Chaim O. Jacob, Kathy Moser Sivils, Patrick M. Gaffney, John B. Harley, Amr H. Sawalha, Betty P. Tsao

Resultado de la investigación: Contribución a RevistaArtículo

54 Citas (Scopus)

Resumen

Objectives: The Xq28 region containing IRAK1 and MECP2 has been identified as a risk locus for systemic lupus erythematosus (SLE) in previous genetic association studies. However, due to the strong linkage disequilibrium between IRAK1 and MECP2, it remains unclear which gene is affected by the underlying causal variant (s) conferring risk of SLE. Methods: We fine-mapped ≥136 SNPs in a ∼227 kb region on Xq28, containing IRAK1, MECP2 and seven adjacent genes (L1CAM, AVPR2, ARHGAP4, NAA10, RENBP HCFC1 and TMEM187), for association with SLE in 15 783 case-control subjects derived from four different ancestral groups. Results: Multiple SNPs showed strong association with SLE in European Americans, Asians and Hispanics at p
Idioma originalEnglish (US)
Páginas (desde-hasta)437-444
Número de páginas8
PublicaciónAnnals of the Rheumatic Diseases
DOI
EstadoPublished - mar 1 2013

Huella dactilar

Systemic Lupus Erythematosus
Genes
Neural Cell Adhesion Molecule L1
Single Nucleotide Polymorphism
Asian Americans
Linkage Disequilibrium
Genetic Association Studies
Hispanic Americans

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Kaufman, Kenneth M. ; Zhao, Jian ; Kelly, Jennifer A. ; Hughes, Travis ; Adler, Adam ; Sanchez, Elena ; Ojwang, Joshua O. ; Langefeld, Carl D. ; Ziegler, Julie T. ; Williams, Adrienne H. ; Comeau, Mary E. ; Marion, Miranda C. ; Glenn, Stuart B. ; Cantor, Rita M. ; Grossman, Jennifer M. ; Hahn, Bevra H. ; Song, Yeong Wook ; Yu, Chack Yung ; James, Judith A. ; Guthridge, Joel M. ; Brown, Elizabeth E. ; Alarcón, Graciela S. ; Kimberly, Robert P. ; Edberg, Jeffrey C. ; Ramsey-Goldman, Rosalind ; Petri, Michelle A. ; Reveille, John D. ; Vilá, Luis M. ; Anaya, Juan Manuel ; Boackle, Susan A. ; Stevens, Anne M. ; Freedman, Barry I. ; Criswell, Lindsey A. ; Pons-Este, Bernardo A. ; Lee, Joo Hyun ; Lee, Ji Seon ; Chang, Deh Ming ; Scofield, R. Hal A ; Gilkeson, Gary S. ; Merrill, Joan T. ; Niewold, Timothy B. ; Vyse, Timothy James ; Bae, Sang Cheol ; Alarcón-Riquelme, Marta E. ; Jacob, Chaim O. ; Sivils, Kathy Moser ; Gaffney, Patrick M. ; Harley, John B. ; Sawalha, Amr H. ; Tsao, Betty P. / Fine mapping of Xq28: Both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups. En: Annals of the Rheumatic Diseases. 2013 ; pp. 437-444.
@article{4308efa0d038444891abcc2372f14845,
title = "Fine mapping of Xq28: Both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups",
abstract = "Objectives: The Xq28 region containing IRAK1 and MECP2 has been identified as a risk locus for systemic lupus erythematosus (SLE) in previous genetic association studies. However, due to the strong linkage disequilibrium between IRAK1 and MECP2, it remains unclear which gene is affected by the underlying causal variant (s) conferring risk of SLE. Methods: We fine-mapped ≥136 SNPs in a ∼227 kb region on Xq28, containing IRAK1, MECP2 and seven adjacent genes (L1CAM, AVPR2, ARHGAP4, NAA10, RENBP HCFC1 and TMEM187), for association with SLE in 15 783 case-control subjects derived from four different ancestral groups. Results: Multiple SNPs showed strong association with SLE in European Americans, Asians and Hispanics at p",
author = "Kaufman, {Kenneth M.} and Jian Zhao and Kelly, {Jennifer A.} and Travis Hughes and Adam Adler and Elena Sanchez and Ojwang, {Joshua O.} and Langefeld, {Carl D.} and Ziegler, {Julie T.} and Williams, {Adrienne H.} and Comeau, {Mary E.} and Marion, {Miranda C.} and Glenn, {Stuart B.} and Cantor, {Rita M.} and Grossman, {Jennifer M.} and Hahn, {Bevra H.} and Song, {Yeong Wook} and Yu, {Chack Yung} and James, {Judith A.} and Guthridge, {Joel M.} and Brown, {Elizabeth E.} and Alarc{\'o}n, {Graciela S.} and Kimberly, {Robert P.} and Edberg, {Jeffrey C.} and Rosalind Ramsey-Goldman and Petri, {Michelle A.} and Reveille, {John D.} and Vil{\'a}, {Luis M.} and Anaya, {Juan Manuel} and Boackle, {Susan A.} and Stevens, {Anne M.} and Freedman, {Barry I.} and Criswell, {Lindsey A.} and Pons-Este, {Bernardo A.} and Lee, {Joo Hyun} and Lee, {Ji Seon} and Chang, {Deh Ming} and Scofield, {R. Hal A} and Gilkeson, {Gary S.} and Merrill, {Joan T.} and Niewold, {Timothy B.} and Vyse, {Timothy James} and Bae, {Sang Cheol} and Alarc{\'o}n-Riquelme, {Marta E.} and Jacob, {Chaim O.} and Sivils, {Kathy Moser} and Gaffney, {Patrick M.} and Harley, {John B.} and Sawalha, {Amr H.} and Tsao, {Betty P.}",
year = "2013",
month = "3",
day = "1",
doi = "10.1136/annrheumdis-2012-201851",
language = "English (US)",
pages = "437--444",
journal = "Annals of the Rheumatic Diseases",
issn = "0003-4967",
publisher = "BMJ Publishing Group",

}

Kaufman, KM, Zhao, J, Kelly, JA, Hughes, T, Adler, A, Sanchez, E, Ojwang, JO, Langefeld, CD, Ziegler, JT, Williams, AH, Comeau, ME, Marion, MC, Glenn, SB, Cantor, RM, Grossman, JM, Hahn, BH, Song, YW, Yu, CY, James, JA, Guthridge, JM, Brown, EE, Alarcón, GS, Kimberly, RP, Edberg, JC, Ramsey-Goldman, R, Petri, MA, Reveille, JD, Vilá, LM, Anaya, JM, Boackle, SA, Stevens, AM, Freedman, BI, Criswell, LA, Pons-Este, BA, Lee, JH, Lee, JS, Chang, DM, Scofield, RHA, Gilkeson, GS, Merrill, JT, Niewold, TB, Vyse, TJ, Bae, SC, Alarcón-Riquelme, ME, Jacob, CO, Sivils, KM, Gaffney, PM, Harley, JB, Sawalha, AH & Tsao, BP 2013, 'Fine mapping of Xq28: Both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups', Annals of the Rheumatic Diseases, pp. 437-444. https://doi.org/10.1136/annrheumdis-2012-201851

Fine mapping of Xq28: Both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups. / Kaufman, Kenneth M.; Zhao, Jian; Kelly, Jennifer A.; Hughes, Travis; Adler, Adam; Sanchez, Elena; Ojwang, Joshua O.; Langefeld, Carl D.; Ziegler, Julie T.; Williams, Adrienne H.; Comeau, Mary E.; Marion, Miranda C.; Glenn, Stuart B.; Cantor, Rita M.; Grossman, Jennifer M.; Hahn, Bevra H.; Song, Yeong Wook; Yu, Chack Yung; James, Judith A.; Guthridge, Joel M.; Brown, Elizabeth E.; Alarcón, Graciela S.; Kimberly, Robert P.; Edberg, Jeffrey C.; Ramsey-Goldman, Rosalind; Petri, Michelle A.; Reveille, John D.; Vilá, Luis M.; Anaya, Juan Manuel; Boackle, Susan A.; Stevens, Anne M.; Freedman, Barry I.; Criswell, Lindsey A.; Pons-Este, Bernardo A.; Lee, Joo Hyun; Lee, Ji Seon; Chang, Deh Ming; Scofield, R. Hal A; Gilkeson, Gary S.; Merrill, Joan T.; Niewold, Timothy B.; Vyse, Timothy James; Bae, Sang Cheol; Alarcón-Riquelme, Marta E.; Jacob, Chaim O.; Sivils, Kathy Moser; Gaffney, Patrick M.; Harley, John B.; Sawalha, Amr H.; Tsao, Betty P.

En: Annals of the Rheumatic Diseases, 01.03.2013, p. 437-444.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Fine mapping of Xq28: Both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups

AU - Kaufman, Kenneth M.

AU - Zhao, Jian

AU - Kelly, Jennifer A.

AU - Hughes, Travis

AU - Adler, Adam

AU - Sanchez, Elena

AU - Ojwang, Joshua O.

AU - Langefeld, Carl D.

AU - Ziegler, Julie T.

AU - Williams, Adrienne H.

AU - Comeau, Mary E.

AU - Marion, Miranda C.

AU - Glenn, Stuart B.

AU - Cantor, Rita M.

AU - Grossman, Jennifer M.

AU - Hahn, Bevra H.

AU - Song, Yeong Wook

AU - Yu, Chack Yung

AU - James, Judith A.

AU - Guthridge, Joel M.

AU - Brown, Elizabeth E.

AU - Alarcón, Graciela S.

AU - Kimberly, Robert P.

AU - Edberg, Jeffrey C.

AU - Ramsey-Goldman, Rosalind

AU - Petri, Michelle A.

AU - Reveille, John D.

AU - Vilá, Luis M.

AU - Anaya, Juan Manuel

AU - Boackle, Susan A.

AU - Stevens, Anne M.

AU - Freedman, Barry I.

AU - Criswell, Lindsey A.

AU - Pons-Este, Bernardo A.

AU - Lee, Joo Hyun

AU - Lee, Ji Seon

AU - Chang, Deh Ming

AU - Scofield, R. Hal A

AU - Gilkeson, Gary S.

AU - Merrill, Joan T.

AU - Niewold, Timothy B.

AU - Vyse, Timothy James

AU - Bae, Sang Cheol

AU - Alarcón-Riquelme, Marta E.

AU - Jacob, Chaim O.

AU - Sivils, Kathy Moser

AU - Gaffney, Patrick M.

AU - Harley, John B.

AU - Sawalha, Amr H.

AU - Tsao, Betty P.

PY - 2013/3/1

Y1 - 2013/3/1

N2 - Objectives: The Xq28 region containing IRAK1 and MECP2 has been identified as a risk locus for systemic lupus erythematosus (SLE) in previous genetic association studies. However, due to the strong linkage disequilibrium between IRAK1 and MECP2, it remains unclear which gene is affected by the underlying causal variant (s) conferring risk of SLE. Methods: We fine-mapped ≥136 SNPs in a ∼227 kb region on Xq28, containing IRAK1, MECP2 and seven adjacent genes (L1CAM, AVPR2, ARHGAP4, NAA10, RENBP HCFC1 and TMEM187), for association with SLE in 15 783 case-control subjects derived from four different ancestral groups. Results: Multiple SNPs showed strong association with SLE in European Americans, Asians and Hispanics at p

AB - Objectives: The Xq28 region containing IRAK1 and MECP2 has been identified as a risk locus for systemic lupus erythematosus (SLE) in previous genetic association studies. However, due to the strong linkage disequilibrium between IRAK1 and MECP2, it remains unclear which gene is affected by the underlying causal variant (s) conferring risk of SLE. Methods: We fine-mapped ≥136 SNPs in a ∼227 kb region on Xq28, containing IRAK1, MECP2 and seven adjacent genes (L1CAM, AVPR2, ARHGAP4, NAA10, RENBP HCFC1 and TMEM187), for association with SLE in 15 783 case-control subjects derived from four different ancestral groups. Results: Multiple SNPs showed strong association with SLE in European Americans, Asians and Hispanics at p

U2 - 10.1136/annrheumdis-2012-201851

DO - 10.1136/annrheumdis-2012-201851

M3 - Article

SP - 437

EP - 444

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

ER -