Fine mapping of Xq28: Both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups

Kenneth M. Kaufman, Jian Zhao, Jennifer A. Kelly, Travis Hughes, Adam Adler, Elena Sanchez, Joshua O. Ojwang, Carl D. Langefeld, Julie T. Ziegler, Adrienne H. Williams, Mary E. Comeau, Miranda C. Marion, Stuart B. Glenn, Rita M. Cantor, Jennifer M. Grossman, Bevra H. Hahn, Yeong Wook Song, Chack Yung Yu, Judith A. James, Joel M. GuthridgeElizabeth E. Brown, Graciela S. Alarcón, Robert P. Kimberly, Jeffrey C. Edberg, Rosalind Ramsey-Goldman, Michelle A. Petri, John D. Reveille, Luis M. Vilá, Juan Manuel Anaya, Susan A. Boackle, Anne M. Stevens, Barry I. Freedman, Lindsey A. Criswell, Bernardo A. Pons-Este, Joo Hyun Lee, Ji Seon Lee, Deh Ming Chang, R. Hal A Scofield, Gary S. Gilkeson, Joan T. Merrill, Timothy B. Niewold, Timothy James Vyse, Sang Cheol Bae, Marta E. Alarcón-Riquelme, Chaim O. Jacob, Kathy Moser Sivils, Patrick M. Gaffney, John B. Harley, Amr H. Sawalha, Betty P. Tsao

Resultado de la investigación: Contribución a una revistaArtículo

68 Citas (Scopus)

Resumen

Objectives: The Xq28 region containing IRAK1 and MECP2 has been identified as a risk locus for systemic lupus erythematosus (SLE) in previous genetic association studies. However, due to the strong linkage disequilibrium between IRAK1 and MECP2, it remains unclear which gene is affected by the underlying causal variant (s) conferring risk of SLE. Methods: We fine-mapped ≥136 SNPs in a ∼227 kb region on Xq28, containing IRAK1, MECP2 and seven adjacent genes (L1CAM, AVPR2, ARHGAP4, NAA10, RENBP HCFC1 and TMEM187), for association with SLE in 15 783 case-control subjects derived from four different ancestral groups. Results: Multiple SNPs showed strong association with SLE in European Americans, Asians and Hispanics at p
Idioma originalInglés estadounidense
Páginas (desde-hasta)437-444
Número de páginas8
PublicaciónAnnals of the Rheumatic Diseases
DOI
EstadoPublicada - mar 1 2013

    Huella digital

Citar esto

Kaufman, K. M., Zhao, J., Kelly, J. A., Hughes, T., Adler, A., Sanchez, E., Ojwang, J. O., Langefeld, C. D., Ziegler, J. T., Williams, A. H., Comeau, M. E., Marion, M. C., Glenn, S. B., Cantor, R. M., Grossman, J. M., Hahn, B. H., Song, Y. W., Yu, C. Y., James, J. A., ... Tsao, B. P. (2013). Fine mapping of Xq28: Both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups. Annals of the Rheumatic Diseases, 437-444. https://doi.org/10.1136/annrheumdis-2012-201851