TY - JOUR
T1 - Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus
AU - Anaya, Juan Manuel
AU - Castiblanco, John
AU - Tobón, Gabriel J.
AU - García, Jorge
AU - Abad, Verónica
AU - Cuervo, Héctor
AU - Velásquez, Alejandro
AU - Angel, Ivan D.
AU - Vega, Patricia
AU - Arango, Alvaro
N1 - Funding Information:
We thank all the patients and participants of this study. Some of the results of this study were obtained by using the program package S.A.G.E., which is supported by a U.S. Public Health Service Resource Grant (RR03655) from the National Center for Research Resources. We also thank the two anonymous reviewers of this paper for their important comments.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006/5
Y1 - 2006/5
N2 - We investigated the familial aggregation of autoimmune diseases (AIDs) among first-degree relatives (FDR) of patients with type 1 diabetes mellitus (T1D). Relatives of 98 T1D patients defined according to the guidelines diagnosis of the American Diabetes Association and 113 matched controls without any AID, were interviewed using a questionnaire that sought information about demographic and medical characteristics including a list of 18 AIDs. Genetic analysis was performed using the program ASSOC and by calculating recurrent risk ratios. In cases, 25.5% of the families had at least one member having an AID, while in controls there were 9% (odds ratio [OR]: 3.96, 95% confidence interval [CI] = 1.74-9.0, p = 0.0006). An AID was registered in 8.3% of 312 FDR of patients as compared with 2.4% of 362 FDR in controls (OR: 3.56, 95% CI = 1.64-7.73, p = 0.0008). The most frequent AIDs registered in FDR of cases were autoimmune thyroid disease (AITD) and T1D, which disclosed coefficients of aggregation. These results indicate that AIDs cluster within families of T1D patients adding further evidence to consider that clinically different autoimmune phenotypes may share common susceptibility gene variants, which may act pleiotropically as risk factors for autoimmunity.
AB - We investigated the familial aggregation of autoimmune diseases (AIDs) among first-degree relatives (FDR) of patients with type 1 diabetes mellitus (T1D). Relatives of 98 T1D patients defined according to the guidelines diagnosis of the American Diabetes Association and 113 matched controls without any AID, were interviewed using a questionnaire that sought information about demographic and medical characteristics including a list of 18 AIDs. Genetic analysis was performed using the program ASSOC and by calculating recurrent risk ratios. In cases, 25.5% of the families had at least one member having an AID, while in controls there were 9% (odds ratio [OR]: 3.96, 95% confidence interval [CI] = 1.74-9.0, p = 0.0006). An AID was registered in 8.3% of 312 FDR of patients as compared with 2.4% of 362 FDR in controls (OR: 3.56, 95% CI = 1.64-7.73, p = 0.0008). The most frequent AIDs registered in FDR of cases were autoimmune thyroid disease (AITD) and T1D, which disclosed coefficients of aggregation. These results indicate that AIDs cluster within families of T1D patients adding further evidence to consider that clinically different autoimmune phenotypes may share common susceptibility gene variants, which may act pleiotropically as risk factors for autoimmunity.
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U2 - 10.1016/j.jaut.2006.01.001
DO - 10.1016/j.jaut.2006.01.001
M3 - Article
C2 - 16503115
AN - SCOPUS:33646681230
SN - 0896-8411
VL - 26
SP - 208
EP - 214
JO - Journal of Autoimmunity
JF - Journal of Autoimmunity
IS - 3
ER -
