Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus

Juan Manuel Anaya, John Castiblanco, Gabriel J. Tobón, Jorge García, Verónica Abad, Héctor Cuervo, Alejandro Velásquez, Ivan D. Angel, Patricia Vega, Alvaro Arango

Resultado de la investigación: Contribución a RevistaArtículo

76 Citas (Scopus)

Resumen

We investigated the familial aggregation of autoimmune diseases (AIDs) among first-degree relatives (FDR) of patients with type 1 diabetes mellitus (T1D). Relatives of 98 T1D patients defined according to the guidelines diagnosis of the American Diabetes Association and 113 matched controls without any AID, were interviewed using a questionnaire that sought information about demographic and medical characteristics including a list of 18 AIDs. Genetic analysis was performed using the program ASSOC and by calculating recurrent risk ratios. In cases, 25.5% of the families had at least one member having an AID, while in controls there were 9% (odds ratio [OR]: 3.96, 95% confidence interval [CI] = 1.74-9.0, p = 0.0006). An AID was registered in 8.3% of 312 FDR of patients as compared with 2.4% of 362 FDR in controls (OR: 3.56, 95% CI = 1.64-7.73, p = 0.0008). The most frequent AIDs registered in FDR of cases were autoimmune thyroid disease (AITD) and T1D, which disclosed coefficients of aggregation. These results indicate that AIDs cluster within families of T1D patients adding further evidence to consider that clinically different autoimmune phenotypes may share common susceptibility gene variants, which may act pleiotropically as risk factors for autoimmunity. © 2006 Elsevier Ltd. All rights reserved.
Idioma originalEnglish (US)
Páginas (desde-hasta)208-214
Número de páginas7
PublicaciónJournal of Autoimmunity
DOI
EstadoPublished - may 1 2006

Huella dactilar

Type 1 Diabetes Mellitus
Autoimmune Diseases
Cluster Analysis
Odds Ratio
Confidence Intervals
Thyroid Diseases
Autoimmunity
Demography
Guidelines
Phenotype
Genes

Citar esto

Anaya, Juan Manuel ; Castiblanco, John ; Tobón, Gabriel J. ; García, Jorge ; Abad, Verónica ; Cuervo, Héctor ; Velásquez, Alejandro ; Angel, Ivan D. ; Vega, Patricia ; Arango, Alvaro. / Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus. En: Journal of Autoimmunity. 2006 ; pp. 208-214.
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abstract = "We investigated the familial aggregation of autoimmune diseases (AIDs) among first-degree relatives (FDR) of patients with type 1 diabetes mellitus (T1D). Relatives of 98 T1D patients defined according to the guidelines diagnosis of the American Diabetes Association and 113 matched controls without any AID, were interviewed using a questionnaire that sought information about demographic and medical characteristics including a list of 18 AIDs. Genetic analysis was performed using the program ASSOC and by calculating recurrent risk ratios. In cases, 25.5{\%} of the families had at least one member having an AID, while in controls there were 9{\%} (odds ratio [OR]: 3.96, 95{\%} confidence interval [CI] = 1.74-9.0, p = 0.0006). An AID was registered in 8.3{\%} of 312 FDR of patients as compared with 2.4{\%} of 362 FDR in controls (OR: 3.56, 95{\%} CI = 1.64-7.73, p = 0.0008). The most frequent AIDs registered in FDR of cases were autoimmune thyroid disease (AITD) and T1D, which disclosed coefficients of aggregation. These results indicate that AIDs cluster within families of T1D patients adding further evidence to consider that clinically different autoimmune phenotypes may share common susceptibility gene variants, which may act pleiotropically as risk factors for autoimmunity. {\circledC} 2006 Elsevier Ltd. All rights reserved.",
author = "Anaya, {Juan Manuel} and John Castiblanco and Tob{\'o}n, {Gabriel J.} and Jorge Garc{\'i}a and Ver{\'o}nica Abad and H{\'e}ctor Cuervo and Alejandro Vel{\'a}squez and Angel, {Ivan D.} and Patricia Vega and Alvaro Arango",
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Anaya, JM, Castiblanco, J, Tobón, GJ, García, J, Abad, V, Cuervo, H, Velásquez, A, Angel, ID, Vega, P & Arango, A 2006, 'Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus', Journal of Autoimmunity, pp. 208-214. https://doi.org/10.1016/j.jaut.2006.01.001

Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus. / Anaya, Juan Manuel; Castiblanco, John; Tobón, Gabriel J.; García, Jorge; Abad, Verónica; Cuervo, Héctor; Velásquez, Alejandro; Angel, Ivan D.; Vega, Patricia; Arango, Alvaro.

En: Journal of Autoimmunity, 01.05.2006, p. 208-214.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus

AU - Anaya, Juan Manuel

AU - Castiblanco, John

AU - Tobón, Gabriel J.

AU - García, Jorge

AU - Abad, Verónica

AU - Cuervo, Héctor

AU - Velásquez, Alejandro

AU - Angel, Ivan D.

AU - Vega, Patricia

AU - Arango, Alvaro

PY - 2006/5/1

Y1 - 2006/5/1

N2 - We investigated the familial aggregation of autoimmune diseases (AIDs) among first-degree relatives (FDR) of patients with type 1 diabetes mellitus (T1D). Relatives of 98 T1D patients defined according to the guidelines diagnosis of the American Diabetes Association and 113 matched controls without any AID, were interviewed using a questionnaire that sought information about demographic and medical characteristics including a list of 18 AIDs. Genetic analysis was performed using the program ASSOC and by calculating recurrent risk ratios. In cases, 25.5% of the families had at least one member having an AID, while in controls there were 9% (odds ratio [OR]: 3.96, 95% confidence interval [CI] = 1.74-9.0, p = 0.0006). An AID was registered in 8.3% of 312 FDR of patients as compared with 2.4% of 362 FDR in controls (OR: 3.56, 95% CI = 1.64-7.73, p = 0.0008). The most frequent AIDs registered in FDR of cases were autoimmune thyroid disease (AITD) and T1D, which disclosed coefficients of aggregation. These results indicate that AIDs cluster within families of T1D patients adding further evidence to consider that clinically different autoimmune phenotypes may share common susceptibility gene variants, which may act pleiotropically as risk factors for autoimmunity. © 2006 Elsevier Ltd. All rights reserved.

AB - We investigated the familial aggregation of autoimmune diseases (AIDs) among first-degree relatives (FDR) of patients with type 1 diabetes mellitus (T1D). Relatives of 98 T1D patients defined according to the guidelines diagnosis of the American Diabetes Association and 113 matched controls without any AID, were interviewed using a questionnaire that sought information about demographic and medical characteristics including a list of 18 AIDs. Genetic analysis was performed using the program ASSOC and by calculating recurrent risk ratios. In cases, 25.5% of the families had at least one member having an AID, while in controls there were 9% (odds ratio [OR]: 3.96, 95% confidence interval [CI] = 1.74-9.0, p = 0.0006). An AID was registered in 8.3% of 312 FDR of patients as compared with 2.4% of 362 FDR in controls (OR: 3.56, 95% CI = 1.64-7.73, p = 0.0008). The most frequent AIDs registered in FDR of cases were autoimmune thyroid disease (AITD) and T1D, which disclosed coefficients of aggregation. These results indicate that AIDs cluster within families of T1D patients adding further evidence to consider that clinically different autoimmune phenotypes may share common susceptibility gene variants, which may act pleiotropically as risk factors for autoimmunity. © 2006 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.jaut.2006.01.001

DO - 10.1016/j.jaut.2006.01.001

M3 - Article

SP - 208

EP - 214

JO - Journal of Autoimmunity

JF - Journal of Autoimmunity

SN - 0896-8411

ER -