Factors influencing polyautoimmunity in systemic lupus erythematosus

Adriana Rojas-Villarraga, Carlos Enrique Toro, Gerard Espinosa, Yolima Rodríguez-Velosa, Carolina Duarte-Rey, Rubén D. Mantilla, Antonio Iglesias-Gamarra, Ricard Cervera, Juan Manuel Anaya

Resultado de la investigación: Contribución a RevistaRevisión Literaria

42 Citas (Scopus)

Resumen

Objective: Since characterization of the extent to which particular combinations of autoimmune diseases (ADs) occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms, polyautoimmunity (i.e., ADs co-occurring within patients) in systemic lupus erythematosus (SLE) and its associated factors were investigated. Methods: This was a cross-sectional study in which 335 consecutive patients with SLE and the history of 22 ADs were investigated. A multivariate analysis was performed. A systematic literature review was done and results were grouped by hierarchical cluster procedure analysis. Results: There were 136 (41%) SLE patients presenting with at least one other AD. A total of 191 ADs were observed, of which the most frequent were autoimmune thyroid disease (AITD), antiphospholipid syndrome (APS) and Sjögren's syndrome (SS), registered in 60 (18%), 48 (14%) and 47 (14%) cases, respectively. Out of a total number of 1515 SLE patients with polyautoimmunity (1379 reported previously and 136 informed here) there were 77 (5.1%) cases with multiple autoimmune syndrome (i.e., two or more ADs in addition to SLE). Female gender, articular involvement, familial autoimmunity, anti-Ro positivity and patient's origin were risk factors for polyautoimmunity while the presence of anti-RNP antibodies was protective. Four clusters of ADs were found. The most hierarchical one was composed of AITD, APS, SS, and systemic sclerosis. Conclusion: Polyautoimmunity is frequent in SLE, and it is influenced by clinical and immunological features. These findings support that clinically different autoimmune phenotypes might share common susceptibility variants. © 2009 Elsevier B.V. All rights reserved.
Idioma originalEnglish (US)
Páginas (desde-hasta)229-232
Número de páginas4
PublicaciónAutoimmunity Reviews
DOI
EstadoPublished - feb 1 2010

Huella dactilar

Systemic Lupus Erythematosus
Autoimmune Diseases
Antiphospholipid Syndrome
Sjogren's Syndrome
Thyroid Diseases
Systemic Scleroderma
Autoimmunity
Cluster Analysis
Anti-Idiotypic Antibodies
Multivariate Analysis
Cross-Sectional Studies
Joints
History
Phenotype

Citar esto

Rojas-Villarraga, A., Toro, C. E., Espinosa, G., Rodríguez-Velosa, Y., Duarte-Rey, C., Mantilla, R. D., ... Anaya, J. M. (2010). Factors influencing polyautoimmunity in systemic lupus erythematosus. Autoimmunity Reviews, 229-232. https://doi.org/10.1016/j.autrev.2009.10.001
Rojas-Villarraga, Adriana ; Toro, Carlos Enrique ; Espinosa, Gerard ; Rodríguez-Velosa, Yolima ; Duarte-Rey, Carolina ; Mantilla, Rubén D. ; Iglesias-Gamarra, Antonio ; Cervera, Ricard ; Anaya, Juan Manuel. / Factors influencing polyautoimmunity in systemic lupus erythematosus. En: Autoimmunity Reviews. 2010 ; pp. 229-232.
@article{e127ddce01c44b9b8a30dee65dc59258,
title = "Factors influencing polyautoimmunity in systemic lupus erythematosus",
abstract = "Objective: Since characterization of the extent to which particular combinations of autoimmune diseases (ADs) occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms, polyautoimmunity (i.e., ADs co-occurring within patients) in systemic lupus erythematosus (SLE) and its associated factors were investigated. Methods: This was a cross-sectional study in which 335 consecutive patients with SLE and the history of 22 ADs were investigated. A multivariate analysis was performed. A systematic literature review was done and results were grouped by hierarchical cluster procedure analysis. Results: There were 136 (41{\%}) SLE patients presenting with at least one other AD. A total of 191 ADs were observed, of which the most frequent were autoimmune thyroid disease (AITD), antiphospholipid syndrome (APS) and Sj{\"o}gren's syndrome (SS), registered in 60 (18{\%}), 48 (14{\%}) and 47 (14{\%}) cases, respectively. Out of a total number of 1515 SLE patients with polyautoimmunity (1379 reported previously and 136 informed here) there were 77 (5.1{\%}) cases with multiple autoimmune syndrome (i.e., two or more ADs in addition to SLE). Female gender, articular involvement, familial autoimmunity, anti-Ro positivity and patient's origin were risk factors for polyautoimmunity while the presence of anti-RNP antibodies was protective. Four clusters of ADs were found. The most hierarchical one was composed of AITD, APS, SS, and systemic sclerosis. Conclusion: Polyautoimmunity is frequent in SLE, and it is influenced by clinical and immunological features. These findings support that clinically different autoimmune phenotypes might share common susceptibility variants. {\circledC} 2009 Elsevier B.V. All rights reserved.",
author = "Adriana Rojas-Villarraga and Toro, {Carlos Enrique} and Gerard Espinosa and Yolima Rodr{\'i}guez-Velosa and Carolina Duarte-Rey and Mantilla, {Rub{\'e}n D.} and Antonio Iglesias-Gamarra and Ricard Cervera and Anaya, {Juan Manuel}",
year = "2010",
month = "2",
day = "1",
doi = "10.1016/j.autrev.2009.10.001",
language = "English (US)",
pages = "229--232",
journal = "Autoimmunity Reviews",
issn = "1568-9972",
publisher = "Elsevier",

}

Rojas-Villarraga, A, Toro, CE, Espinosa, G, Rodríguez-Velosa, Y, Duarte-Rey, C, Mantilla, RD, Iglesias-Gamarra, A, Cervera, R & Anaya, JM 2010, 'Factors influencing polyautoimmunity in systemic lupus erythematosus', Autoimmunity Reviews, pp. 229-232. https://doi.org/10.1016/j.autrev.2009.10.001

Factors influencing polyautoimmunity in systemic lupus erythematosus. / Rojas-Villarraga, Adriana; Toro, Carlos Enrique; Espinosa, Gerard; Rodríguez-Velosa, Yolima; Duarte-Rey, Carolina; Mantilla, Rubén D.; Iglesias-Gamarra, Antonio; Cervera, Ricard; Anaya, Juan Manuel.

En: Autoimmunity Reviews, 01.02.2010, p. 229-232.

Resultado de la investigación: Contribución a RevistaRevisión Literaria

TY - JOUR

T1 - Factors influencing polyautoimmunity in systemic lupus erythematosus

AU - Rojas-Villarraga, Adriana

AU - Toro, Carlos Enrique

AU - Espinosa, Gerard

AU - Rodríguez-Velosa, Yolima

AU - Duarte-Rey, Carolina

AU - Mantilla, Rubén D.

AU - Iglesias-Gamarra, Antonio

AU - Cervera, Ricard

AU - Anaya, Juan Manuel

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Objective: Since characterization of the extent to which particular combinations of autoimmune diseases (ADs) occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms, polyautoimmunity (i.e., ADs co-occurring within patients) in systemic lupus erythematosus (SLE) and its associated factors were investigated. Methods: This was a cross-sectional study in which 335 consecutive patients with SLE and the history of 22 ADs were investigated. A multivariate analysis was performed. A systematic literature review was done and results were grouped by hierarchical cluster procedure analysis. Results: There were 136 (41%) SLE patients presenting with at least one other AD. A total of 191 ADs were observed, of which the most frequent were autoimmune thyroid disease (AITD), antiphospholipid syndrome (APS) and Sjögren's syndrome (SS), registered in 60 (18%), 48 (14%) and 47 (14%) cases, respectively. Out of a total number of 1515 SLE patients with polyautoimmunity (1379 reported previously and 136 informed here) there were 77 (5.1%) cases with multiple autoimmune syndrome (i.e., two or more ADs in addition to SLE). Female gender, articular involvement, familial autoimmunity, anti-Ro positivity and patient's origin were risk factors for polyautoimmunity while the presence of anti-RNP antibodies was protective. Four clusters of ADs were found. The most hierarchical one was composed of AITD, APS, SS, and systemic sclerosis. Conclusion: Polyautoimmunity is frequent in SLE, and it is influenced by clinical and immunological features. These findings support that clinically different autoimmune phenotypes might share common susceptibility variants. © 2009 Elsevier B.V. All rights reserved.

AB - Objective: Since characterization of the extent to which particular combinations of autoimmune diseases (ADs) occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms, polyautoimmunity (i.e., ADs co-occurring within patients) in systemic lupus erythematosus (SLE) and its associated factors were investigated. Methods: This was a cross-sectional study in which 335 consecutive patients with SLE and the history of 22 ADs were investigated. A multivariate analysis was performed. A systematic literature review was done and results were grouped by hierarchical cluster procedure analysis. Results: There were 136 (41%) SLE patients presenting with at least one other AD. A total of 191 ADs were observed, of which the most frequent were autoimmune thyroid disease (AITD), antiphospholipid syndrome (APS) and Sjögren's syndrome (SS), registered in 60 (18%), 48 (14%) and 47 (14%) cases, respectively. Out of a total number of 1515 SLE patients with polyautoimmunity (1379 reported previously and 136 informed here) there were 77 (5.1%) cases with multiple autoimmune syndrome (i.e., two or more ADs in addition to SLE). Female gender, articular involvement, familial autoimmunity, anti-Ro positivity and patient's origin were risk factors for polyautoimmunity while the presence of anti-RNP antibodies was protective. Four clusters of ADs were found. The most hierarchical one was composed of AITD, APS, SS, and systemic sclerosis. Conclusion: Polyautoimmunity is frequent in SLE, and it is influenced by clinical and immunological features. These findings support that clinically different autoimmune phenotypes might share common susceptibility variants. © 2009 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.autrev.2009.10.001

DO - 10.1016/j.autrev.2009.10.001

M3 - Literature review

SP - 229

EP - 232

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

SN - 1568-9972

ER -

Rojas-Villarraga A, Toro CE, Espinosa G, Rodríguez-Velosa Y, Duarte-Rey C, Mantilla RD y otros. Factors influencing polyautoimmunity in systemic lupus erythematosus. Autoimmunity Reviews. 2010 feb 1;229-232. https://doi.org/10.1016/j.autrev.2009.10.001