Exposure to Epstein-Barr Virus Infection Is Associated with Mild Systemic Lupus Erythematosus Disease

Gisele Zandman-Goddard, Yackov Berkun, Ori Barzilai, Mona Boaz, Miri Blank, Maya Ram, Yaniv Sherer, Juan Manuel Anaya, Yehuda Shoenfeld

Resultado de la investigación: Capítulo en Libro/Reporte/ConferenciaCapítulo

68 Citas (Scopus)

Resumen

Infections may act as environmental triggers for the induction of systemic lupus erythematosus (SLE). In this study, we determine the relationship between disease manifestations of SLE patients and the titers of five Epstein-Barr virus (EBV) Abs. We evaluated the titers of early antigen IgG (EAG), nuclear antigen IgG, viral capsid antigen (VCA) IgG and IgM, and heterophile IgM, using the BioPlex 2200 multiplexed immunoassay method in 260 sera (120 SLE patients and 140 controls). EAG titers were significantly elevated (P < 0.024) in patients with cutaneous symptoms and increased anti-Ro antibody titers (P < 0.005). VCA IgG titers were significantly elevated (P < 0.003) in patients with joint involvement. None of the titers differed by central nervous system or renal involvement or antiphospholipid syndrome. We conclude that exposure to EBV infection may predict a disease phenotype of mild SLE disease with cutaneous and joint manifestations and elevated titers of anti-Ro Abs.
Idioma originalInglés
Título de la publicación alojadaCONTEMPORARY CHALLENGES IN AUTOIMMUNITY
Páginas658-663
Volumen1173
DOI
EstadoPublicada - 2009

Serie de la publicación

NombreANNALS OF THE NEW YORK ACADEMY OF SCIENCES

Citar esto

Zandman-Goddard, G., Berkun, Y., Barzilai, O., Boaz, M., Blank, M., Ram, M., Sherer, Y., Manuel Anaya, J., & Shoenfeld, Y. (2009). Exposure to Epstein-Barr Virus Infection Is Associated with Mild Systemic Lupus Erythematosus Disease. En CONTEMPORARY CHALLENGES IN AUTOIMMUNITY (Vol. 1173, pp. 658-663). (ANNALS OF THE NEW YORK ACADEMY OF SCIENCES). https://doi.org/10.1111/j.1749-6632.2009.04754.x