Exposure to Epstein-Barr Virus Infection Is Associated with Mild Systemic Lupus Erythematosus Disease

Gisele Zandman-Goddard, Yackov Berkun, Ori Barzilai, Mona Boaz, Miri Blank, Maya Ram, Yaniv Sherer, Juan Manuel Anaya, Yehuda Shoenfeld

Resultado de la investigación: Contribución a libro /Tipo informe o reporteCapítulo

64 Citas (Scopus)

Resumen

Infections may act as environmental triggers for the induction of systemic lupus erythematosus (SLE). In this study, we determine the relationship between disease manifestations of SLE patients and the titers of five Epstein-Barr virus (EBV) Abs. We evaluated the titers of early antigen IgG (EAG), nuclear antigen IgG, viral capsid antigen (VCA) IgG and IgM, and heterophile IgM, using the BioPlex 2200 multiplexed immunoassay method in 260 sera (120 SLE patients and 140 controls). EAG titers were significantly elevated (P < 0.024) in patients with cutaneous symptoms and increased anti-Ro antibody titers (P < 0.005). VCA IgG titers were significantly elevated (P < 0.003) in patients with joint involvement. None of the titers differed by central nervous system or renal involvement or antiphospholipid syndrome. We conclude that exposure to EBV infection may predict a disease phenotype of mild SLE disease with cutaneous and joint manifestations and elevated titers of anti-Ro Abs.
Idioma originalEnglish
Título de la publicación alojadaCONTEMPORARY CHALLENGES IN AUTOIMMUNITY
Páginas658-663
Volumen1173
DOI
EstadoPublished - 2009

Serie de la publicación

NombreANNALS OF THE NEW YORK ACADEMY OF SCIENCES

Citar esto

Zandman-Goddard, G., Berkun, Y., Barzilai, O., Boaz, M., Blank, M., Ram, M., ... Shoenfeld, Y. (2009). Exposure to Epstein-Barr Virus Infection Is Associated with Mild Systemic Lupus Erythematosus Disease. En CONTEMPORARY CHALLENGES IN AUTOIMMUNITY (Vol. 1173, pp. 658-663). (ANNALS OF THE NEW YORK ACADEMY OF SCIENCES). https://doi.org/10.1111/j.1749-6632.2009.04754.x
Zandman-Goddard, Gisele ; Berkun, Yackov ; Barzilai, Ori ; Boaz, Mona ; Blank, Miri ; Ram, Maya ; Sherer, Yaniv ; Manuel Anaya, Juan ; Shoenfeld, Yehuda. / Exposure to Epstein-Barr Virus Infection Is Associated with Mild Systemic Lupus Erythematosus Disease. CONTEMPORARY CHALLENGES IN AUTOIMMUNITY. Vol. 1173 2009. pp. 658-663 (ANNALS OF THE NEW YORK ACADEMY OF SCIENCES).
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abstract = "Infections may act as environmental triggers for the induction of systemic lupus erythematosus (SLE). In this study, we determine the relationship between disease manifestations of SLE patients and the titers of five Epstein-Barr virus (EBV) Abs. We evaluated the titers of early antigen IgG (EAG), nuclear antigen IgG, viral capsid antigen (VCA) IgG and IgM, and heterophile IgM, using the BioPlex 2200 multiplexed immunoassay method in 260 sera (120 SLE patients and 140 controls). EAG titers were significantly elevated (P < 0.024) in patients with cutaneous symptoms and increased anti-Ro antibody titers (P < 0.005). VCA IgG titers were significantly elevated (P < 0.003) in patients with joint involvement. None of the titers differed by central nervous system or renal involvement or antiphospholipid syndrome. We conclude that exposure to EBV infection may predict a disease phenotype of mild SLE disease with cutaneous and joint manifestations and elevated titers of anti-Ro Abs.",
author = "Gisele Zandman-Goddard and Yackov Berkun and Ori Barzilai and Mona Boaz and Miri Blank and Maya Ram and Yaniv Sherer and {Manuel Anaya}, Juan and Yehuda Shoenfeld",
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Zandman-Goddard, G, Berkun, Y, Barzilai, O, Boaz, M, Blank, M, Ram, M, Sherer, Y, Manuel Anaya, J & Shoenfeld, Y 2009, Exposure to Epstein-Barr Virus Infection Is Associated with Mild Systemic Lupus Erythematosus Disease. En CONTEMPORARY CHALLENGES IN AUTOIMMUNITY. vol. 1173, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, pp. 658-663. https://doi.org/10.1111/j.1749-6632.2009.04754.x

Exposure to Epstein-Barr Virus Infection Is Associated with Mild Systemic Lupus Erythematosus Disease. / Zandman-Goddard, Gisele; Berkun, Yackov; Barzilai, Ori; Boaz, Mona; Blank, Miri; Ram, Maya; Sherer, Yaniv; Manuel Anaya, Juan; Shoenfeld, Yehuda.

CONTEMPORARY CHALLENGES IN AUTOIMMUNITY. Vol. 1173 2009. p. 658-663 (ANNALS OF THE NEW YORK ACADEMY OF SCIENCES).

Resultado de la investigación: Contribución a libro /Tipo informe o reporteCapítulo

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T1 - Exposure to Epstein-Barr Virus Infection Is Associated with Mild Systemic Lupus Erythematosus Disease

AU - Zandman-Goddard, Gisele

AU - Berkun, Yackov

AU - Barzilai, Ori

AU - Boaz, Mona

AU - Blank, Miri

AU - Ram, Maya

AU - Sherer, Yaniv

AU - Manuel Anaya, Juan

AU - Shoenfeld, Yehuda

PY - 2009

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N2 - Infections may act as environmental triggers for the induction of systemic lupus erythematosus (SLE). In this study, we determine the relationship between disease manifestations of SLE patients and the titers of five Epstein-Barr virus (EBV) Abs. We evaluated the titers of early antigen IgG (EAG), nuclear antigen IgG, viral capsid antigen (VCA) IgG and IgM, and heterophile IgM, using the BioPlex 2200 multiplexed immunoassay method in 260 sera (120 SLE patients and 140 controls). EAG titers were significantly elevated (P < 0.024) in patients with cutaneous symptoms and increased anti-Ro antibody titers (P < 0.005). VCA IgG titers were significantly elevated (P < 0.003) in patients with joint involvement. None of the titers differed by central nervous system or renal involvement or antiphospholipid syndrome. We conclude that exposure to EBV infection may predict a disease phenotype of mild SLE disease with cutaneous and joint manifestations and elevated titers of anti-Ro Abs.

AB - Infections may act as environmental triggers for the induction of systemic lupus erythematosus (SLE). In this study, we determine the relationship between disease manifestations of SLE patients and the titers of five Epstein-Barr virus (EBV) Abs. We evaluated the titers of early antigen IgG (EAG), nuclear antigen IgG, viral capsid antigen (VCA) IgG and IgM, and heterophile IgM, using the BioPlex 2200 multiplexed immunoassay method in 260 sera (120 SLE patients and 140 controls). EAG titers were significantly elevated (P < 0.024) in patients with cutaneous symptoms and increased anti-Ro antibody titers (P < 0.005). VCA IgG titers were significantly elevated (P < 0.003) in patients with joint involvement. None of the titers differed by central nervous system or renal involvement or antiphospholipid syndrome. We conclude that exposure to EBV infection may predict a disease phenotype of mild SLE disease with cutaneous and joint manifestations and elevated titers of anti-Ro Abs.

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DO - 10.1111/j.1749-6632.2009.04754.x

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SN - 978-1-57331-762-7

VL - 1173

T3 - ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

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BT - CONTEMPORARY CHALLENGES IN AUTOIMMUNITY

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Zandman-Goddard G, Berkun Y, Barzilai O, Boaz M, Blank M, Ram M y otros. Exposure to Epstein-Barr Virus Infection Is Associated with Mild Systemic Lupus Erythematosus Disease. En CONTEMPORARY CHALLENGES IN AUTOIMMUNITY. Vol. 1173. 2009. p. 658-663. (ANNALS OF THE NEW YORK ACADEMY OF SCIENCES). https://doi.org/10.1111/j.1749-6632.2009.04754.x