Exploration of Natural Compounds in Interaction with Gamma-Aminobutyric Acid Through Molecular Docking: Towards New Therapies for Anxiety

Anxiety disorders are characterized by excessive fear and physical tension, even in the absence of real danger. Their origin is linked to genetic factors, traumatic experiences, and biochemical imbalances, particularly involving the neurotransmitter GABA. Although treatments like benzodiazepines are effective, long-Term use can lead to cognitive side effects, prompting interest in natural alternatives. Several studies have evaluated bioactive compounds found in plants and foods such as Camellia sinensis, Agaricus bisporus, and Ricinus communis Linn, demonstrating anxiolytic effects in animal models and favorable results in molecular docking studies. These findings suggest that natural compounds may modulate GABA receptor activity. This study aims to investigate the affinity of selected biomolecules with GABA as a potential alternative therapy for the treatment of anxiety disorders.