Evidence of bovine leukemia virus circulating in sheep and buffaloes in Colombia: insights into multispecies infection

Nury N. Olaya-Galán; Adriana P. Corredor-Figueroa; Sebastián Velandia-Álvarez; Diana S. Vargas-Bermudez; Nathalia Fonseca-Ahumada; Kerlimber Nuñez; Jairo Jaime; María Fernanda Gutiérrez

doi:10.1007/s00705-021-05285-7

Evidence of bovine leukemia virus circulating in sheep and buffaloes in Colombia: insights into multispecies infection

Título traducido de la contribución: Evidencia de circulación del virus de la leucemia bovina en ovinos y búfalos en Colombia: conocimientos sobre la infección multiespecífica

Nury N. Olaya-Galán, Adriana P. Corredor-Figueroa, Sebastián Velandia-Álvarez, Diana S. Vargas-Bermudez, Nathalia Fonseca-Ahumada, Kerlimber Nuñez, Jairo Jaime, María Fernanda Gutiérrez

Escuela de Medicina y Ciencias de la Salud

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

5 Citas (Scopus)

Resumen

El virus de la leucemia bovina (BLV) es el agente causante de la leucemia/linfoma en el ganado vacuno. Sin embargo, pruebas anteriores han demostrado su presencia en otras especies de ganado, así como en el ser humano, lo que sugiere que otras especies pueden ser huéspedes accidentales del virus. En las infecciones víricas, se propone que los receptores comunes a distintas especies animales intervengan en las infecciones entre especies. En el caso del BLV, se ha propuesto que AP3D1 es su receptor, y esta proteína está conservada en la mayoría de las especies de mamíferos. En Colombia, el BLV ha sido reportado en bovinos con altas tasas de prevalencia, pero no ha habido evidencia de infecciones por BLV en otras especies animales. En este estudio se analizó la presencia del virus en ovejas (n = 44) y búfalos (n = 61) de diferentes regiones de Colombia mediante PCR anidada, utilizando muestras de sangre periférica recogidas de los animales. El 25,7% de los animales analizados (12 búfalos y 15 ovejas) estaban infectados por BLV, y los resultados se confirmaron mediante secuenciación de Sanger. Además, para obtener más información sobre la capacidad del virus para infectar a estas especies, se analizaron in silico las interacciones previstas de AP3D1 de ovejas y búfalos con la proteína BLV-gp51. Se identificaron aminoácidos conservados en los dominios de unión de las proteínas. La detección de BLV en ovejas y búfalos sugiere la circulación del virus en múltiples especies, lo que podría estar implicado en la diseminación del virus en entornos de producción ganadera mixta. Debido a la presencia del virus en múltiples especies y a las elevadas tasas de prevalencia observadas, se deben considerar estrategias integradas de prevención y control en la industria ganadera para disminuir la propagación del BLV.

Título traducido de la contribución	Evidencia de circulación del virus de la leucemia bovina en ovinos y búfalos en Colombia: conocimientos sobre la infección multiespecífica
Idioma original	Inglés estadounidense
Páginas (desde-hasta)	807–817
Número de páginas	10
Publicación	Archives of Virology
Volumen	167
DOI	https://doi.org/10.1007/s00705-021-05285-7
Estado	Publicada - nov. 11 2021

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Virología

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@article{7a6c89ac29c44991a24863bbddeeeb4e,

title = "Evidence of bovine leukemia virus circulating in sheep and buffaloes in Colombia: insights into multispecies infection",

abstract = "Bovine leukemia virus (BLV) is the causative agent of leukemia/lymphoma in cattle. However, previous evidence has shown its presence in other species of livestock as well as in humans, suggesting that other species can be accidental hosts of the virus. In viral infections, receptors that are common to different animal species are proposed to be involved in cross-species infections. For BLV, AP3D1 has been proposed to be its receptor, and this protein is conserved in most mammalian species. In Colombia, BLV has been reported in cattle with high prevalence rates, but there has been no evidence of BLV infections in other animal species. In this study, we tested for the virus in sheep (n = 44) and buffaloes (n = 61) from different regions of Colombia by nested PCR, using peripheral blood samples collected from the animals. BLV was found in 25.7% of the animals tested (12 buffaloes and 15 sheep), and the results were confirmed by Sanger sequencing. In addition, to gain more information about the capacity of the virus to infect these species, the predicted interactions of AP3D1 of sheep and buffaloes with the BLV-gp51 protein were analyzed in silico. Conserved amino acids in the binding domains of the proteins were identified. The detection of BLV in sheep and buffaloes suggests circulation of the virus in multiple species, which could be involved in dissemination of the virus in mixed livestock production settings. Due to the presence of the virus in multiple species and the high prevalence rates observed, integrated prevention and control strategies in the livestock industry should be considered to decrease the spread of BLV.",

author = "Olaya-Gal{\'a}n, {Nury N.} and Corredor-Figueroa, {Adriana P.} and Sebasti{\'a}n Velandia-{\'A}lvarez and Vargas-Bermudez, {Diana S.} and Nathalia Fonseca-Ahumada and Kerlimber Nu{\~n}ez and Jairo Jaime and Guti{\'e}rrez, {Mar{\'i}a Fernanda}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.",

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doi = "10.1007/s00705-021-05285-7",

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T2 - insights into multispecies infection

AU - Olaya-Galán, Nury N.

AU - Corredor-Figueroa, Adriana P.

AU - Velandia-Álvarez, Sebastián

AU - Vargas-Bermudez, Diana S.

AU - Fonseca-Ahumada, Nathalia

AU - Nuñez, Kerlimber

AU - Jaime, Jairo

AU - Gutiérrez, María Fernanda

PY - 2021/11/11

Y1 - 2021/11/11

N2 - Bovine leukemia virus (BLV) is the causative agent of leukemia/lymphoma in cattle. However, previous evidence has shown its presence in other species of livestock as well as in humans, suggesting that other species can be accidental hosts of the virus. In viral infections, receptors that are common to different animal species are proposed to be involved in cross-species infections. For BLV, AP3D1 has been proposed to be its receptor, and this protein is conserved in most mammalian species. In Colombia, BLV has been reported in cattle with high prevalence rates, but there has been no evidence of BLV infections in other animal species. In this study, we tested for the virus in sheep (n = 44) and buffaloes (n = 61) from different regions of Colombia by nested PCR, using peripheral blood samples collected from the animals. BLV was found in 25.7% of the animals tested (12 buffaloes and 15 sheep), and the results were confirmed by Sanger sequencing. In addition, to gain more information about the capacity of the virus to infect these species, the predicted interactions of AP3D1 of sheep and buffaloes with the BLV-gp51 protein were analyzed in silico. Conserved amino acids in the binding domains of the proteins were identified. The detection of BLV in sheep and buffaloes suggests circulation of the virus in multiple species, which could be involved in dissemination of the virus in mixed livestock production settings. Due to the presence of the virus in multiple species and the high prevalence rates observed, integrated prevention and control strategies in the livestock industry should be considered to decrease the spread of BLV.

AB - Bovine leukemia virus (BLV) is the causative agent of leukemia/lymphoma in cattle. However, previous evidence has shown its presence in other species of livestock as well as in humans, suggesting that other species can be accidental hosts of the virus. In viral infections, receptors that are common to different animal species are proposed to be involved in cross-species infections. For BLV, AP3D1 has been proposed to be its receptor, and this protein is conserved in most mammalian species. In Colombia, BLV has been reported in cattle with high prevalence rates, but there has been no evidence of BLV infections in other animal species. In this study, we tested for the virus in sheep (n = 44) and buffaloes (n = 61) from different regions of Colombia by nested PCR, using peripheral blood samples collected from the animals. BLV was found in 25.7% of the animals tested (12 buffaloes and 15 sheep), and the results were confirmed by Sanger sequencing. In addition, to gain more information about the capacity of the virus to infect these species, the predicted interactions of AP3D1 of sheep and buffaloes with the BLV-gp51 protein were analyzed in silico. Conserved amino acids in the binding domains of the proteins were identified. The detection of BLV in sheep and buffaloes suggests circulation of the virus in multiple species, which could be involved in dissemination of the virus in mixed livestock production settings. Due to the presence of the virus in multiple species and the high prevalence rates observed, integrated prevention and control strategies in the livestock industry should be considered to decrease the spread of BLV.

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JO - Archives of Virology

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ER -

Evidence of bovine leukemia virus circulating in sheep and buffaloes in Colombia: insights into multispecies infection

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