Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus

E. Sánchez, L. M. Gómez, M. A. Lopez-Nevot, M. A. González-Gay, J. M. Sabio, N. Ortego-Centeno, E. de Ramón, J. M. Anaya, M. F. González-Escribano, B. P. Koeleman, J. Martín

Resultado de la investigación: Contribución a RevistaArtículo

74 Citas (Scopus)

Resumen

The aim of this study was to evaluate the potential association of functional polymorphisms of macrophage migration inhibitory factor with systemic lupus erythematosus. Our study includes 711 systemic lupus erythematosus (SLE) patients and 755 healthy controls. We genotyped the migration inhibitory factor (MIF) -173G/C using a polymerase chain reaction (PCR) system with predeveloped TaqMan allelic discrimination assay and the MIF -794 CATTn microsatellite polymorphism using a PCR-fluorescent method. A statistically significant difference in the distribution of the MIF -173*C allele between SLE patients and controls (P=0.004, OR=1.34, 95% CI=1.05-1.27) was observed. In addition, the frequency of the MIF -173* C/C genotype was higher in SLE patient (P=0.002, OR 2.58, 95% CI 1.32-5.10). No differences in the distribution of CATTn were found. However, the haplotypes analyses showed that only the CATT7-MIF -173* C haplotype was associated with a higher susceptibility to SLE (P=0.001, OR 1.84, 95% CI 1.35-2.79). No association with clinical features was detected in any case. These results suggest that both, MIF -173*C allele and CATT7-MIF -173*C haplotype, confer susceptibility to SLE in our population. © 2006 Nature Publishing Group. All rights reserved.
Idioma originalEnglish (US)
Páginas (desde-hasta)433-436
Número de páginas4
PublicaciónGenes and Immunity
DOI
EstadoPublished - jul 1 2006

Huella dactilar

Macrophage Migration-Inhibitory Factors
Systemic Lupus Erythematosus
Haplotypes
Genes
Alleles
Polymerase Chain Reaction
Microsatellite Repeats
Genotype
Population

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Sánchez, E., Gómez, L. M., Lopez-Nevot, M. A., González-Gay, M. A., Sabio, J. M., Ortego-Centeno, N., ... Martín, J. (2006). Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus. Genes and Immunity, 433-436. https://doi.org/10.1038/sj.gene.6364310
Sánchez, E. ; Gómez, L. M. ; Lopez-Nevot, M. A. ; González-Gay, M. A. ; Sabio, J. M. ; Ortego-Centeno, N. ; de Ramón, E. ; Anaya, J. M. ; González-Escribano, M. F. ; Koeleman, B. P. ; Martín, J. / Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus. En: Genes and Immunity. 2006 ; pp. 433-436.
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title = "Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus",
abstract = "The aim of this study was to evaluate the potential association of functional polymorphisms of macrophage migration inhibitory factor with systemic lupus erythematosus. Our study includes 711 systemic lupus erythematosus (SLE) patients and 755 healthy controls. We genotyped the migration inhibitory factor (MIF) -173G/C using a polymerase chain reaction (PCR) system with predeveloped TaqMan allelic discrimination assay and the MIF -794 CATTn microsatellite polymorphism using a PCR-fluorescent method. A statistically significant difference in the distribution of the MIF -173*C allele between SLE patients and controls (P=0.004, OR=1.34, 95{\%} CI=1.05-1.27) was observed. In addition, the frequency of the MIF -173* C/C genotype was higher in SLE patient (P=0.002, OR 2.58, 95{\%} CI 1.32-5.10). No differences in the distribution of CATTn were found. However, the haplotypes analyses showed that only the CATT7-MIF -173* C haplotype was associated with a higher susceptibility to SLE (P=0.001, OR 1.84, 95{\%} CI 1.35-2.79). No association with clinical features was detected in any case. These results suggest that both, MIF -173*C allele and CATT7-MIF -173*C haplotype, confer susceptibility to SLE in our population. {\circledC} 2006 Nature Publishing Group. All rights reserved.",
author = "E. S{\'a}nchez and G{\'o}mez, {L. M.} and Lopez-Nevot, {M. A.} and Gonz{\'a}lez-Gay, {M. A.} and Sabio, {J. M.} and N. Ortego-Centeno and {de Ram{\'o}n}, E. and Anaya, {J. M.} and Gonz{\'a}lez-Escribano, {M. F.} and Koeleman, {B. P.} and J. Mart{\'i}n",
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Sánchez, E, Gómez, LM, Lopez-Nevot, MA, González-Gay, MA, Sabio, JM, Ortego-Centeno, N, de Ramón, E, Anaya, JM, González-Escribano, MF, Koeleman, BP & Martín, J 2006, 'Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus', Genes and Immunity, pp. 433-436. https://doi.org/10.1038/sj.gene.6364310

Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus. / Sánchez, E.; Gómez, L. M.; Lopez-Nevot, M. A.; González-Gay, M. A.; Sabio, J. M.; Ortego-Centeno, N.; de Ramón, E.; Anaya, J. M.; González-Escribano, M. F.; Koeleman, B. P.; Martín, J.

En: Genes and Immunity, 01.07.2006, p. 433-436.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus

AU - Sánchez, E.

AU - Gómez, L. M.

AU - Lopez-Nevot, M. A.

AU - González-Gay, M. A.

AU - Sabio, J. M.

AU - Ortego-Centeno, N.

AU - de Ramón, E.

AU - Anaya, J. M.

AU - González-Escribano, M. F.

AU - Koeleman, B. P.

AU - Martín, J.

PY - 2006/7/1

Y1 - 2006/7/1

N2 - The aim of this study was to evaluate the potential association of functional polymorphisms of macrophage migration inhibitory factor with systemic lupus erythematosus. Our study includes 711 systemic lupus erythematosus (SLE) patients and 755 healthy controls. We genotyped the migration inhibitory factor (MIF) -173G/C using a polymerase chain reaction (PCR) system with predeveloped TaqMan allelic discrimination assay and the MIF -794 CATTn microsatellite polymorphism using a PCR-fluorescent method. A statistically significant difference in the distribution of the MIF -173*C allele between SLE patients and controls (P=0.004, OR=1.34, 95% CI=1.05-1.27) was observed. In addition, the frequency of the MIF -173* C/C genotype was higher in SLE patient (P=0.002, OR 2.58, 95% CI 1.32-5.10). No differences in the distribution of CATTn were found. However, the haplotypes analyses showed that only the CATT7-MIF -173* C haplotype was associated with a higher susceptibility to SLE (P=0.001, OR 1.84, 95% CI 1.35-2.79). No association with clinical features was detected in any case. These results suggest that both, MIF -173*C allele and CATT7-MIF -173*C haplotype, confer susceptibility to SLE in our population. © 2006 Nature Publishing Group. All rights reserved.

AB - The aim of this study was to evaluate the potential association of functional polymorphisms of macrophage migration inhibitory factor with systemic lupus erythematosus. Our study includes 711 systemic lupus erythematosus (SLE) patients and 755 healthy controls. We genotyped the migration inhibitory factor (MIF) -173G/C using a polymerase chain reaction (PCR) system with predeveloped TaqMan allelic discrimination assay and the MIF -794 CATTn microsatellite polymorphism using a PCR-fluorescent method. A statistically significant difference in the distribution of the MIF -173*C allele between SLE patients and controls (P=0.004, OR=1.34, 95% CI=1.05-1.27) was observed. In addition, the frequency of the MIF -173* C/C genotype was higher in SLE patient (P=0.002, OR 2.58, 95% CI 1.32-5.10). No differences in the distribution of CATTn were found. However, the haplotypes analyses showed that only the CATT7-MIF -173* C haplotype was associated with a higher susceptibility to SLE (P=0.001, OR 1.84, 95% CI 1.35-2.79). No association with clinical features was detected in any case. These results suggest that both, MIF -173*C allele and CATT7-MIF -173*C haplotype, confer susceptibility to SLE in our population. © 2006 Nature Publishing Group. All rights reserved.

U2 - 10.1038/sj.gene.6364310

DO - 10.1038/sj.gene.6364310

M3 - Article

SP - 433

EP - 436

JO - Genes and Immunity

JF - Genes and Immunity

SN - 1466-4879

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Sánchez E, Gómez LM, Lopez-Nevot MA, González-Gay MA, Sabio JM, Ortego-Centeno N y otros. Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus. Genes and Immunity. 2006 jul 1;433-436. https://doi.org/10.1038/sj.gene.6364310