Evaluation of OIDx Histoplasma urinary antigen EIA

Diego H Cáceres; Beatriz L. Gómez; Ángela M Tobón; Tom M Chiller; Mark D Lindsley

doi:10.1007/s11046-021-00602-9

Evaluation of OIDx Histoplasma urinary antigen EIA

Título traducido de la contribución: Evaluación del antígeno urinario de Histoplasma OIDx EIA

Diego H Cáceres
, Beatriz L. Gómez
, Ángela M Tobón
, Tom M Chiller
, Mark D Lindsley

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

15 Citas (Scopus)

Resumen

Se evaluó un enzimoinmunoanálisis (EIA) en sándwich para la detección de antígenos (Ag) de Histoplasma en orina, desarrollado por Optimum Imaging Diagnostics (OIDx). Una verificación utilizando un panel de referencia estandarizado de muestras de orina encontró una sensibilidad del 92%, una especificidad del 32% y una precisión del 51%. En este estudio, el EIA Histoplasma Ag urinario de OIDx mostró una alta sensibilidad, sin embargo, en casos de no histoplasmosis este EIA mostró resultados falsos positivos en el 68% de las muestras analizadas.

Título traducido de la contribución	Evaluación del antígeno urinario de Histoplasma OIDx EIA
Idioma original	Inglés estadounidense
Páginas (desde-hasta)	129–131
Publicación	Mycopathologia
Volumen	187
DOI	https://doi.org/10.1007/s11046-021-00602-9
Estado	Publicada - nov 20 2021

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

ODS 3: Salud y bienestar

Áreas temáticas de ASJC Scopus

Medicina General

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10.1007/s11046-021-00602-9

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title = "Evaluation of OIDx Histoplasma urinary antigen EIA",

abstract = "A sandwich enzyme immunoassay (EIA) for the detection of Histoplasma antigens (Ag) in urine, developed by Optimum Imaging Diagnostics (OIDx) was evaluated. A verification using a standardized reference panel of urine samples found sensitivity of 92\%, specificity of 32\% and accuracy of 51\%. In this study, the OIDx Histoplasma urinary Ag EIA displayed high sensitivity, however, in non-histoplasmosis cases this EIA displayed false-positive results in 68\% of specimens tested.",

author = "C{\'a}ceres, \{Diego H\} and G{\'o}mez, \{Beatriz L.\} and Tob{\'o}n, \{{\'A}ngela M\} and Chiller, \{Tom M\} and Lindsley, \{Mark D\}",

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doi = "10.1007/s11046-021-00602-9",

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T1 - Evaluation of OIDx Histoplasma urinary antigen EIA

AU - Cáceres, Diego H

AU - Gómez, Beatriz L.

AU - Tobón, Ángela M

AU - Chiller, Tom M

AU - Lindsley, Mark D

PY - 2021/11/20

Y1 - 2021/11/20

N2 - A sandwich enzyme immunoassay (EIA) for the detection of Histoplasma antigens (Ag) in urine, developed by Optimum Imaging Diagnostics (OIDx) was evaluated. A verification using a standardized reference panel of urine samples found sensitivity of 92%, specificity of 32% and accuracy of 51%. In this study, the OIDx Histoplasma urinary Ag EIA displayed high sensitivity, however, in non-histoplasmosis cases this EIA displayed false-positive results in 68% of specimens tested.

AB - A sandwich enzyme immunoassay (EIA) for the detection of Histoplasma antigens (Ag) in urine, developed by Optimum Imaging Diagnostics (OIDx) was evaluated. A verification using a standardized reference panel of urine samples found sensitivity of 92%, specificity of 32% and accuracy of 51%. In this study, the OIDx Histoplasma urinary Ag EIA displayed high sensitivity, however, in non-histoplasmosis cases this EIA displayed false-positive results in 68% of specimens tested.

U2 - 10.1007/s11046-021-00602-9

DO - 10.1007/s11046-021-00602-9

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SN - 0301-486X

VL - 187

SP - 129

EP - 131

JO - Mycopathologia

JF - Mycopathologia