Evaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia

Diego H Cáceres, Alejandra Zuluaga, Ángela M Tabares, Tom Chiller, Ángel González, Beatriz L Gómez

Resultado de la investigación: Contribución a RevistaArtículo

2 Citas (Scopus)

Resumen

A Lateral Flow Assay to detect cryptococcal antigen (CrAg® LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg® LFA was 100%. High concordance (kappa index=1.0) between Cryptococcal Antigen Latex Agglutination System (CALAS®) and CrAg® LFA was observed. CrAg® LFA showed higher analytical sensitivity for detecting low concentrations of cryptococcal antigen.

Idioma originalEnglish (US)
Páginas (desde-hasta)e76
PublicaciónRevista do Instituto de Medicina Tropical de Sao Paulo
Volumen59
DOI
EstadoPublished - dic 21 2017
Publicado de forma externa

Huella dactilar

Cryptococcosis
Colombia
Cerebrospinal Fluid
Antigens
Serum
Agglutination
Latex
Sensitivity and Specificity

Citar esto

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title = "Evaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia",
abstract = "A Lateral Flow Assay to detect cryptococcal antigen (CrAg{\circledR} LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg{\circledR} LFA was 100{\%}. High concordance (kappa index=1.0) between Cryptococcal Antigen Latex Agglutination System (CALAS{\circledR}) and CrAg{\circledR} LFA was observed. CrAg{\circledR} LFA showed higher analytical sensitivity for detecting low concentrations of cryptococcal antigen.",
author = "C{\'a}ceres, {Diego H} and Alejandra Zuluaga and Tabares, {{\'A}ngela M} and Tom Chiller and {\'A}ngel Gonz{\'a}lez and G{\'o}mez, {Beatriz L}",
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Evaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia. / Cáceres, Diego H; Zuluaga, Alejandra; Tabares, Ángela M; Chiller, Tom; González, Ángel; Gómez, Beatriz L.

En: Revista do Instituto de Medicina Tropical de Sao Paulo, Vol. 59, 21.12.2017, p. e76.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Evaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia

AU - Cáceres, Diego H

AU - Zuluaga, Alejandra

AU - Tabares, Ángela M

AU - Chiller, Tom

AU - González, Ángel

AU - Gómez, Beatriz L

PY - 2017/12/21

Y1 - 2017/12/21

N2 - A Lateral Flow Assay to detect cryptococcal antigen (CrAg® LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg® LFA was 100%. High concordance (kappa index=1.0) between Cryptococcal Antigen Latex Agglutination System (CALAS®) and CrAg® LFA was observed. CrAg® LFA showed higher analytical sensitivity for detecting low concentrations of cryptococcal antigen.

AB - A Lateral Flow Assay to detect cryptococcal antigen (CrAg® LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg® LFA was 100%. High concordance (kappa index=1.0) between Cryptococcal Antigen Latex Agglutination System (CALAS®) and CrAg® LFA was observed. CrAg® LFA showed higher analytical sensitivity for detecting low concentrations of cryptococcal antigen.

U2 - 10.1590/S1678-9946201759076

DO - 10.1590/S1678-9946201759076

M3 - Article

C2 - 29267584

VL - 59

SP - e76

JO - Revista do Instituto de Medicina Tropical de Sao Paulo

JF - Revista do Instituto de Medicina Tropical de Sao Paulo

SN - 0036-4665

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