Epstein-Barr virus and cytomegalovirus in autoimmune diseases: Are they truly notorious? A preliminary report

O. Barzilai, Y. Sherer, M. Ram, D. Izhaky, J. M. Anaya, Yehuda Shoenfeld

Resultado de la investigación: Capítulo en Libro/Reporte/ConferenciaContribución a la conferencia

163 Citas (Scopus)

Resumen

To date, it is believed that the origin of autoimmune diseases is one of a multifactorial background. A genetic predisposition, an immune system malfunction or even backfire, hormonal regulation, and environmental factors all play important roles in the pathogenesis of autoimmune diseases. Among these environmental factors, the role of infection is known to be a major one. Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are considered to be notorious as they are consistently associated with multiple autoimmune diseases. A cohort of 1595 serum samples, of 23 different autoimmune disease groups, was screened for evidence of prior infection with EBV and CMV. All samples were screened for antibodies against EBV nuclear antigen-1 (IgG), EBV viral capsid antigen (IgG and IgM), EBV early antigen (IgG), EBV heterophile antibody, and CMV (IgG and IgM) antibodies using Bio-Rad's BioPlex 2200. A new association is proposed between EBV and polymyositis, as results show a significant increase in titers of various EBV target analytes when compared with healthy controls. Our results also support prior information suggesting the association between EBV and multiple autoimmune diseases, including SLE, antiphospholipid syndrome, rheumatoid arthritis, multiple sclerosis, pemphigus vulgaris, giant cell arthritis, Wegener's granulomatosis, and polyarteritis nodosa (PAN). Elevated CMV IgG titers were observed in sera of SLE patients. Our data support the theory that EBV is notoriously associated with many autoimmune diseases. CMV appears to be associated to autoimmune diseases as well, yet establishing this theory requires further investigation.

Idioma originalInglés estadounidense
Título de la publicación alojadaAutoimmunity, Part D
Subtítulo de la publicación alojadaAutoimmune Disease, Annus Mirabilis
EditorialBlackwell Publishing, Inc.
Páginas567-577
Número de páginas11
ISBN (versión impresa)157331708X, 9781573317085
DOI
EstadoPublicada - jun 2007
Publicado de forma externa

Serie de la publicación

NombreAnnals of the New York Academy of Sciences
Volumen1108
ISSN (versión impresa)0077-8923
ISSN (versión digital)1749-6632

All Science Journal Classification (ASJC) codes

  • Neurociencia (todo)
  • Bioquímica, genética y biología molecular (todo)
  • Historia y filosofía de la ciencia

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