Efectos agudos de los protocolos de intervalos de alta intensidad, resistencia o ejercicios combinados sobre la testosterona - respuestas al cortisol en individuos inactivos con sobrepeso

Gina P. Velasco-Orjuela, María A. Domínguez-Sanchéz, Enrique Hernández, Jorge E. Correa-Bautista, Héctor R. Triana-Reina, Antonio García-Hermoso, Jhonatan C. Peña-Ibagon, Mikel Izquierdo, Eduardo L. Cadore, Anthony C. Hackney, Robinson Ramírez-Vélez

Resultado de la investigación: Contribución a RevistaArtículo

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Resumen

El propósito de este estudio fue comparar las respuestas hormonales con una sesión de entrenamiento a intervalos de alta intensidad (HIIT, intervalos de 4 × 4 minutos a una frecuencia cardíaca máxima de 85-95%[HRmax], intercalados con 4 minutos de recuperación a una HRmax de 75-85%), entrenamiento de resistencia (RT a un máximo de 50-70% de una repetición de un máximo de 12-15 repeticiones por sesión con 60 segundos de recuperación) o ambos (HIIT+RT) protocolo de ejercicio en una cohorte de adultos inactivos físicamente y con sobrepeso (18-30 años de edad). Ensayo clínico aleatorizado de grupos paralelos en 51 hombres (23,6 ± 3,5 años; 83,5 ± 7,8 kg; 28,0 ± 1,9 kg/m2), inactividad física (p. ej, Se asignaron al azar a los siguientes cuatro grupos: entrenamiento a intervalos de alta intensidad (HIIT, n = 14), entrenamiento de resistencia (RT, n = 12), entrenamiento combinado a intervalos de alta intensidad y entrenamiento de resistencia (HIIT+RT, n = 13), o control sin ejercicio (CON, n = 12), con obesidad abdominal (circunferencia de la cintura ≥ cm) o índice de masa corporal ≥ y ≤ Las evaluaciones de cortisol, testosterona total y libre y relación total de testosterona/cortisol (T/C) (todas en suero) se determinaron antes (pre) y 1 minuto después del ejercicio para cada sesión de protocolo. Las disminuciones en los niveles de cortisol fueron de -57,08 (IC del 95%: -75,58 a -38,58; p = 0,001; ɳ = 0,61) y -37,65 (IC del 95%: -54,36 a -20,93; p = 0,001; ɳ = 0,51) en el grupo de HIIT y de control, respectivamente. Los aumentos en la relación T/C fueron de 0,022 (IC del 95%: 0,012 a 0,031; p = 0,001; ɳ = 0,49) y 0,015 (IC del 95%: 0,004 a 0,025; p = 0,007; ɳ = 0,29) en el grupo HIIT y el grupo control, respectivamente. En los análisis por protocolo se reveló un cambio significativo en los niveles de cortisol[efecto de interacción F(7,777), ɳ = 0,33] y la relación T/C[efecto de interacción F(5,298), ɳ = 0,25] entre grupos a lo largo del tiempo. Además, se demostró que tanto en los análisis por intención de tratar (intention-to-treat analysis, ITT) como en los análisis por protocolo, el HIIT+RT no cambió el cortisol sérico, la testosterona total o libre. Los datos actuales indican que el HIIT redujo el cortisol y aumentó la proporción total de testosterona/cortisol significativamente en adultos físicamente inactivos. Se requieren estudios adicionales para determinar la importancia biológica de estos cambios en las respuestas hormonales en hombres con sobrepeso.
Título traducido de la contribuciónEfectos agudos de los protocolos de intervalos de alta intensidad, resistencia o ejercicios combinados sobre la testosterona - respuestas al cortisol en individuos inactivos con sobrepeso
IdiomaEnglish (US)
Páginas401-409
Número de páginas9
PublicaciónPhysiology and Behavior
Volumen194
DOI
EstadoPublished - oct 1 2018

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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Velasco-Orjuela, Gina P. ; Domínguez-Sanchéz, María A. ; Hernández, Enrique ; Correa-Bautista, Jorge E. ; Triana-Reina, Héctor R. ; García-Hermoso, Antonio ; Peña-Ibagon, Jhonatan C. ; Izquierdo, Mikel ; Cadore, Eduardo L. ; Hackney, Anthony C. ; Ramírez-Vélez, Robinson. / Acute effects of high-intensity interval, resistance or combined exercise protocols on testosterone – cortisol responses in inactive overweight individuals. En: Physiology and Behavior. 2018 ; Vol. 194. pp. 401-409.
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title = "Acute effects of high-intensity interval, resistance or combined exercise protocols on testosterone – cortisol responses in inactive overweight individuals",
abstract = "The purpose of this study was to compare the hormonal responses to one session of high-intensity interval training (HIIT, 4 × 4 min intervals at 85–95{\%} maximum heart rate [HRmax], interspersed with 4 min of recovery at 75–85{\%} HRmax), resistance training (RT at 50–70{\%} of one repetition maximum 12–15 repetitions per set with 60s of recovery) or both (HIIT+RT) exercise protocol in a cohort of physical inactivity, overweight adults (age 18–30 years old). Randomized, parallel-group clinical trial among fifty-one men (23.6 ± 3.5 yr; 83.5 ± 7.8 kg; 28.0 ± 1.9 kg/m2), physical inactivity (i.e., <150 min of moderate-intensity exercise per week for >6 months), with abdominal obesity (waist circumference ≥90 cm) or body mass index ≥25 and ≤30 kg/m2 were randomized to the following 4 groups: high-intensity interval training (HIIT, n = 14), resistance training (RT, n = 12), combined high-intensity interval and resistance training (HIIT+RT, n = 13), or non-exercising control (CON, n = 12). Cortisol, total- and free-testosterone and total-testosterone/cortisol-ratio (T/C) assessments (all in serum) were determined before (pre) and 1-min post-exercise for each protocol session. Decreases in cortisol levels were −57.08 (95{\%}CI, −75.58 to −38.58; P = 0.001; ɳ2 = 0.61) and − 37.65 (95{\%}CI, −54.36 to −20.93; P = 0.001; ɳ2 = 0.51) in the HIIT and control group, respectively. Increases in T/C ratio were 0.022 (95{\%}CI, 0.012 to 0.031; P = 0.001; ɳ2 = 0.49) and 0.015 (95{\%}CI, 0.004 to 0.025; P = 0.007; ɳ2 = 0.29) in the HIIT and control group, respectively. In per-protocol analyses revealed a significant change in cortisol levels [interaction effect F(7.777), ɳ2 = 0.33] and T/C ratio [interaction effect F(5.298), ɳ2 = 0.25] between groups over time. Additionally, we showed that in both the intention-to-treat (ITT) and per protocol analyses, HIIT+RT did not change serum cortisol, total or free testosterone. The present data indicate a HIIT reduced cortisol and increased total-testosterone/cortisol-ratio levels significantly in physically inactive adults. Further study is required to determine the biological importance of these changes in hormonal responses in overweight men.",
author = "Velasco-Orjuela, {Gina P.} and Dom{\'i}nguez-Sanch{\'e}z, {Mar{\'i}a A.} and Enrique Hern{\'a}ndez and Correa-Bautista, {Jorge E.} and Triana-Reina, {H{\'e}ctor R.} and Antonio Garc{\'i}a-Hermoso and Pe{\~n}a-Ibagon, {Jhonatan C.} and Mikel Izquierdo and Cadore, {Eduardo L.} and Hackney, {Anthony C.} and Robinson Ram{\'i}rez-V{\'e}lez",
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Velasco-Orjuela, GP, Domínguez-Sanchéz, MA, Hernández, E, Correa-Bautista, JE, Triana-Reina, HR, García-Hermoso, A, Peña-Ibagon, JC, Izquierdo, M, Cadore, EL, Hackney, AC & Ramírez-Vélez, R 2018, 'Acute effects of high-intensity interval, resistance or combined exercise protocols on testosterone – cortisol responses in inactive overweight individuals' Physiology and Behavior, vol. 194, pp. 401-409. https://doi.org/10.1016/j.physbeh.2018.06.034

Acute effects of high-intensity interval, resistance or combined exercise protocols on testosterone – cortisol responses in inactive overweight individuals. / Velasco-Orjuela, Gina P.; Domínguez-Sanchéz, María A.; Hernández, Enrique; Correa-Bautista, Jorge E.; Triana-Reina, Héctor R.; García-Hermoso, Antonio; Peña-Ibagon, Jhonatan C.; Izquierdo, Mikel; Cadore, Eduardo L.; Hackney, Anthony C.; Ramírez-Vélez, Robinson.

En: Physiology and Behavior, Vol. 194, 01.10.2018, p. 401-409.

Resultado de la investigación: Contribución a RevistaArtículo

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T1 - Acute effects of high-intensity interval, resistance or combined exercise protocols on testosterone – cortisol responses in inactive overweight individuals

AU - Velasco-Orjuela, Gina P.

AU - Domínguez-Sanchéz, María A.

AU - Hernández, Enrique

AU - Correa-Bautista, Jorge E.

AU - Triana-Reina, Héctor R.

AU - García-Hermoso, Antonio

AU - Peña-Ibagon, Jhonatan C.

AU - Izquierdo, Mikel

AU - Cadore, Eduardo L.

AU - Hackney, Anthony C.

AU - Ramírez-Vélez, Robinson

PY - 2018/10/1

Y1 - 2018/10/1

N2 - The purpose of this study was to compare the hormonal responses to one session of high-intensity interval training (HIIT, 4 × 4 min intervals at 85–95% maximum heart rate [HRmax], interspersed with 4 min of recovery at 75–85% HRmax), resistance training (RT at 50–70% of one repetition maximum 12–15 repetitions per set with 60s of recovery) or both (HIIT+RT) exercise protocol in a cohort of physical inactivity, overweight adults (age 18–30 years old). Randomized, parallel-group clinical trial among fifty-one men (23.6 ± 3.5 yr; 83.5 ± 7.8 kg; 28.0 ± 1.9 kg/m2), physical inactivity (i.e., <150 min of moderate-intensity exercise per week for >6 months), with abdominal obesity (waist circumference ≥90 cm) or body mass index ≥25 and ≤30 kg/m2 were randomized to the following 4 groups: high-intensity interval training (HIIT, n = 14), resistance training (RT, n = 12), combined high-intensity interval and resistance training (HIIT+RT, n = 13), or non-exercising control (CON, n = 12). Cortisol, total- and free-testosterone and total-testosterone/cortisol-ratio (T/C) assessments (all in serum) were determined before (pre) and 1-min post-exercise for each protocol session. Decreases in cortisol levels were −57.08 (95%CI, −75.58 to −38.58; P = 0.001; ɳ2 = 0.61) and − 37.65 (95%CI, −54.36 to −20.93; P = 0.001; ɳ2 = 0.51) in the HIIT and control group, respectively. Increases in T/C ratio were 0.022 (95%CI, 0.012 to 0.031; P = 0.001; ɳ2 = 0.49) and 0.015 (95%CI, 0.004 to 0.025; P = 0.007; ɳ2 = 0.29) in the HIIT and control group, respectively. In per-protocol analyses revealed a significant change in cortisol levels [interaction effect F(7.777), ɳ2 = 0.33] and T/C ratio [interaction effect F(5.298), ɳ2 = 0.25] between groups over time. Additionally, we showed that in both the intention-to-treat (ITT) and per protocol analyses, HIIT+RT did not change serum cortisol, total or free testosterone. The present data indicate a HIIT reduced cortisol and increased total-testosterone/cortisol-ratio levels significantly in physically inactive adults. Further study is required to determine the biological importance of these changes in hormonal responses in overweight men.

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