Efectos agudos de alta intensidad, resistencia o protocolo combinado sobre el aumento del nivel de factores neurotróficos en adultos con sobrepeso físicamente inactivos: El estudio BrainFit

María A. Domínguez-Sanchéz, Rosa H. Bustos-Cruz, Gina P. Velasco-Orjuela, Andrea P. Quintero, Alejandra Tordecilla-Sanders, Jorge E. Correa-Bautista, Héctor R. Triana-Reina, Antonio García-Hermoso, Katherine González-Ruíz, Carlos A. Peña-Guzmán, Enrique Hernández, Jhonatan C. Peña-Ibagon, Luis A. Téllez-T, Mikel Izquierdo, Robinson Ramírez-Vélez

Resultado de la investigación: Contribución a RevistaArtículo

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Resumen

El propósito de este estudio fue comparar la respuesta del factor neurotrófico después de una sesión de ejercicio de alta intensidad, entrenamiento de resistencia o ambos en una cohorte de adultos con sobrepeso físicamente inactivos de 18-30 años de edad. Un ensayo clínico aleatorizado de 51 hombres (23,6 ± 3,5 años; 83,5 ± 7,8 kg; 28,0 ± 1,9 kg/m2) que son físicamente inactivos (por ejemplo Los resultados de los ejercicios de intensidad moderada por semana o la puntuación del IPAQ de < 600 MET min/semana durante más de 6 meses) y son obesos abdominales (circunferencia de la cintura ≤ cm) o tienen un índice de masa corporal, el IMC ≤ y ≤ 30 kg/m2 se asignaron al azar a los siguientes cuatro protocolos de ejercicios: ejercicio de alta intensidad (intervalos de 4 × 4 minutos a una frecuencia cardíaca máxima del 85-95%[HRmax] intercalados con 4 minutos de recuperación al 75-85% HRmax) (n = 14), entrenamiento de resistencia (12-15 repeticiones por serie, a un máximo de 50-70% de una repetición con 60 s de recuperación) (n = 12), ejercicio combinado de alta intensidad y resistencia (n = 13), o control sin ejercicio (n = 12). Los niveles plasmáticos de neurotrofina-3 (NT-3), neurotrofina-4 (también conocida como neurotrofina 4/5; NT-4 o NT-4/5) y factor neurotrófico derivado del cerebro (BDNF) se determinaron antes (antes del ejercicio) y 1 minuto después del ejercicio para cada sesión de protocolo. El entrenamiento de resistencia indujo aumentos significativos en NT-3 (+39,6 ng/mL[IC del 95%: 2,5 a 76,6; p = 0,004] y NT-4/5 (+1,3 ng/mL[IC del 95%: 0,3 a 2,3; p = 0,014]), respectivamente). Además, el entrenamiento combinado resulta en efectos favorables sobre el BDNF (+22.0, IC del 95%, 2.6-41.5; p = 0.029) y NT-3 (+32.9 ng/mL[IC del 95%, 12.3-53.4; p = 0.004]), respectivamente. El análisis de regresión reveló una relación positiva significativa entre los cambios en los niveles de BDNF y los cambios en los niveles de NT-4/5 desde el punto de partida hasta el ejercicio inmediatamente posterior al ejercicio en el grupo de entrenamiento combinado (R2 = 0,345; p = 0,034), pero no en los otros grupos de intervención. Los resultados indican que el entrenamiento de resistencia aguda y el ejercicio combinado aumentan los factores neurotróficos en adultos con sobrepeso físicamente inactivos. Se requieren estudios adicionales para determinar la importancia biológica de los cambios en las respuestas neurotróficas en hombres con sobrepeso y los efectos crónicos de estos protocolos de ejercicio.
Título traducido de la contribuciónEfectos agudos de alta intensidad, resistencia o protocolo combinado sobre el aumento del nivel de factores neurotróficos en adultos con sobrepeso físicamente inactivos: El estudio BrainFit
IdiomaEnglish (US)
Número de artículo741
PublicaciónFrontiers in Physiology
Volumen9
Número de ediciónJUN
DOI
EstadoPublished - jun 27 2018

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

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Domínguez-Sanchéz, María A. ; Bustos-Cruz, Rosa H. ; Velasco-Orjuela, Gina P. ; Quintero, Andrea P. ; Tordecilla-Sanders, Alejandra ; Correa-Bautista, Jorge E. ; Triana-Reina, Héctor R. ; García-Hermoso, Antonio ; González-Ruíz, Katherine ; Peña-Guzmán, Carlos A. ; Hernández, Enrique ; Peña-Ibagon, Jhonatan C. ; Téllez-T, Luis A. ; Izquierdo, Mikel ; Ramírez-Vélez, Robinson. / Acute effects of high intensity, resistance, or combined protocol on the increase of level of neurotrophic factors in physically inactive overweight adults : The BrainFit Study. En: Frontiers in Physiology. 2018 ; Vol. 9, N.º JUN.
@article{036d9ee41dd64f59b56cc7a683880239,
title = "Acute effects of high intensity, resistance, or combined protocol on the increase of level of neurotrophic factors in physically inactive overweight adults: The BrainFit Study",
abstract = "The purpose of this study was to compare the neurotrophic factor response following one session of high-intensity exercise, resistance training or both in a cohort of physically inactive overweight adults aged 18-30 years old. A randomized, parallel-group clinical trial of 51 men (23.6 ± 3.5 years; 83.5 ± 7.8 kg; 28.0 ± 1.9 kg/m2) who are physically inactive (i.e., < 150 min of moderate-intensity exercise per week or IPAQ score of < 600 MET min/week for > 6 months) and are either abdominally obese (waist circumference ≥90 cm) or have a body mass index, BMI ≥25 and ≤ 30 kg/m2 were randomized to the following four exercise protocols: high-intensity exercise (4 × 4 min intervals at 85-95{\%} maximum heart rate [HRmax] interspersed with 4 min of recovery at 75-85{\%} HRmax) (n = 14), resistance training (12-15 repetitions per set, at 50-70{\%} of one repetition maximum with 60 s of recovery) (n = 12), combined high-intensity and resistance exercise (n = 13), or non-exercising control (n = 12). The plasma levels of neurotrophin-3 (NT-3), neurotrophin-4 (also known as neurotrophin 4/5; NT-4 or NT-4/5), and brain-derived neurotrophic factor (BDNF) were determined before (pre-exercise) and 1-min post-exercise for each protocol session. Resistance training induced significant increases in NT-3 (+39.6 ng/mL [95{\%} CI, 2.5-76.6; p = 0.004], and NT-4/5 (+1.3 ng/mL [95{\%} CI, 0.3-2.3; p = 0.014]), respectively. Additionally, combined training results in favorable effects on BDNF (+22.0, 95{\%} CI, 2.6-41.5; p = 0.029) and NT-3 (+32.9 ng/mL [95{\%} CI, 12.3-53.4; p = 0.004]), respectively. The regression analysis revealed a significant positive relationship between changes in BDNF levels and changes in NT-4/5 levels from baseline to immediate post-exercise in the combined training group (R2 = 0.345, p = 0.034) but not the other intervention groups. The findings indicate that acute resistance training and combined exercise increase neurotrophic factors in physically inactive overweight adults. Further studies are required to determine the biological importance of changes in neurotrophic responses in overweight men and chronic effects of these exercise protocols.",
author = "Dom{\'i}nguez-Sanch{\'e}z, {Mar{\'i}a A.} and Bustos-Cruz, {Rosa H.} and Velasco-Orjuela, {Gina P.} and Quintero, {Andrea P.} and Alejandra Tordecilla-Sanders and Correa-Bautista, {Jorge E.} and Triana-Reina, {H{\'e}ctor R.} and Antonio Garc{\'i}a-Hermoso and Katherine Gonz{\'a}lez-Ru{\'i}z and Pe{\~n}a-Guzm{\'a}n, {Carlos A.} and Enrique Hern{\'a}ndez and Pe{\~n}a-Ibagon, {Jhonatan C.} and T{\'e}llez-T, {Luis A.} and Mikel Izquierdo and Robinson Ram{\'i}rez-V{\'e}lez",
year = "2018",
month = "6",
day = "27",
doi = "10.3389/fphys.2018.00741",
language = "English (US)",
volume = "9",
journal = "Frontiers in Physiology",
issn = "1664-042X",
publisher = "Frontiers Research Foundation",
number = "JUN",

}

Domínguez-Sanchéz, MA, Bustos-Cruz, RH, Velasco-Orjuela, GP, Quintero, AP, Tordecilla-Sanders, A, Correa-Bautista, JE, Triana-Reina, HR, García-Hermoso, A, González-Ruíz, K, Peña-Guzmán, CA, Hernández, E, Peña-Ibagon, JC, Téllez-T, LA, Izquierdo, M & Ramírez-Vélez, R 2018, 'Acute effects of high intensity, resistance, or combined protocol on the increase of level of neurotrophic factors in physically inactive overweight adults: The BrainFit Study' Frontiers in Physiology, vol. 9, n.º JUN, 741. https://doi.org/10.3389/fphys.2018.00741

Acute effects of high intensity, resistance, or combined protocol on the increase of level of neurotrophic factors in physically inactive overweight adults : The BrainFit Study. / Domínguez-Sanchéz, María A.; Bustos-Cruz, Rosa H.; Velasco-Orjuela, Gina P.; Quintero, Andrea P.; Tordecilla-Sanders, Alejandra; Correa-Bautista, Jorge E.; Triana-Reina, Héctor R.; García-Hermoso, Antonio; González-Ruíz, Katherine; Peña-Guzmán, Carlos A.; Hernández, Enrique; Peña-Ibagon, Jhonatan C.; Téllez-T, Luis A.; Izquierdo, Mikel; Ramírez-Vélez, Robinson.

En: Frontiers in Physiology, Vol. 9, N.º JUN, 741, 27.06.2018.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Acute effects of high intensity, resistance, or combined protocol on the increase of level of neurotrophic factors in physically inactive overweight adults

T2 - Frontiers in Physiology

AU - Domínguez-Sanchéz, María A.

AU - Bustos-Cruz, Rosa H.

AU - Velasco-Orjuela, Gina P.

AU - Quintero, Andrea P.

AU - Tordecilla-Sanders, Alejandra

AU - Correa-Bautista, Jorge E.

AU - Triana-Reina, Héctor R.

AU - García-Hermoso, Antonio

AU - González-Ruíz, Katherine

AU - Peña-Guzmán, Carlos A.

AU - Hernández, Enrique

AU - Peña-Ibagon, Jhonatan C.

AU - Téllez-T, Luis A.

AU - Izquierdo, Mikel

AU - Ramírez-Vélez, Robinson

PY - 2018/6/27

Y1 - 2018/6/27

N2 - The purpose of this study was to compare the neurotrophic factor response following one session of high-intensity exercise, resistance training or both in a cohort of physically inactive overweight adults aged 18-30 years old. A randomized, parallel-group clinical trial of 51 men (23.6 ± 3.5 years; 83.5 ± 7.8 kg; 28.0 ± 1.9 kg/m2) who are physically inactive (i.e., < 150 min of moderate-intensity exercise per week or IPAQ score of < 600 MET min/week for > 6 months) and are either abdominally obese (waist circumference ≥90 cm) or have a body mass index, BMI ≥25 and ≤ 30 kg/m2 were randomized to the following four exercise protocols: high-intensity exercise (4 × 4 min intervals at 85-95% maximum heart rate [HRmax] interspersed with 4 min of recovery at 75-85% HRmax) (n = 14), resistance training (12-15 repetitions per set, at 50-70% of one repetition maximum with 60 s of recovery) (n = 12), combined high-intensity and resistance exercise (n = 13), or non-exercising control (n = 12). The plasma levels of neurotrophin-3 (NT-3), neurotrophin-4 (also known as neurotrophin 4/5; NT-4 or NT-4/5), and brain-derived neurotrophic factor (BDNF) were determined before (pre-exercise) and 1-min post-exercise for each protocol session. Resistance training induced significant increases in NT-3 (+39.6 ng/mL [95% CI, 2.5-76.6; p = 0.004], and NT-4/5 (+1.3 ng/mL [95% CI, 0.3-2.3; p = 0.014]), respectively. Additionally, combined training results in favorable effects on BDNF (+22.0, 95% CI, 2.6-41.5; p = 0.029) and NT-3 (+32.9 ng/mL [95% CI, 12.3-53.4; p = 0.004]), respectively. The regression analysis revealed a significant positive relationship between changes in BDNF levels and changes in NT-4/5 levels from baseline to immediate post-exercise in the combined training group (R2 = 0.345, p = 0.034) but not the other intervention groups. The findings indicate that acute resistance training and combined exercise increase neurotrophic factors in physically inactive overweight adults. Further studies are required to determine the biological importance of changes in neurotrophic responses in overweight men and chronic effects of these exercise protocols.

AB - The purpose of this study was to compare the neurotrophic factor response following one session of high-intensity exercise, resistance training or both in a cohort of physically inactive overweight adults aged 18-30 years old. A randomized, parallel-group clinical trial of 51 men (23.6 ± 3.5 years; 83.5 ± 7.8 kg; 28.0 ± 1.9 kg/m2) who are physically inactive (i.e., < 150 min of moderate-intensity exercise per week or IPAQ score of < 600 MET min/week for > 6 months) and are either abdominally obese (waist circumference ≥90 cm) or have a body mass index, BMI ≥25 and ≤ 30 kg/m2 were randomized to the following four exercise protocols: high-intensity exercise (4 × 4 min intervals at 85-95% maximum heart rate [HRmax] interspersed with 4 min of recovery at 75-85% HRmax) (n = 14), resistance training (12-15 repetitions per set, at 50-70% of one repetition maximum with 60 s of recovery) (n = 12), combined high-intensity and resistance exercise (n = 13), or non-exercising control (n = 12). The plasma levels of neurotrophin-3 (NT-3), neurotrophin-4 (also known as neurotrophin 4/5; NT-4 or NT-4/5), and brain-derived neurotrophic factor (BDNF) were determined before (pre-exercise) and 1-min post-exercise for each protocol session. Resistance training induced significant increases in NT-3 (+39.6 ng/mL [95% CI, 2.5-76.6; p = 0.004], and NT-4/5 (+1.3 ng/mL [95% CI, 0.3-2.3; p = 0.014]), respectively. Additionally, combined training results in favorable effects on BDNF (+22.0, 95% CI, 2.6-41.5; p = 0.029) and NT-3 (+32.9 ng/mL [95% CI, 12.3-53.4; p = 0.004]), respectively. The regression analysis revealed a significant positive relationship between changes in BDNF levels and changes in NT-4/5 levels from baseline to immediate post-exercise in the combined training group (R2 = 0.345, p = 0.034) but not the other intervention groups. The findings indicate that acute resistance training and combined exercise increase neurotrophic factors in physically inactive overweight adults. Further studies are required to determine the biological importance of changes in neurotrophic responses in overweight men and chronic effects of these exercise protocols.

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