Efecto de la deficiencia de vitamina D sobre la hipocalcemia tras tiroidectomía total por bocio benigno

Manuel Díez, Cristina Vera, Tomás Ratia, Lucía Diego, Fernando Mendoza, Paloma Guillamot, Rosario San Román, José M. Mugüerza, ángel Rodríguez, Carlos Medina, Beatriz Gómez, Javier Granell

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

14 Citas (Scopus)

Resumen

Introduction: The purpose of this study was to analyse the relationship between preoperative serum levels of vitamin D and postoperative hypocalcaemia after total thyroidectomy. Material and methods: A prospective observational study was conducted on 113 patients treated by total thyroidectomy due to benign disease. Preoperative vitamin D serum levels and postoperative albumin-corrected calcium and parathormone (PTH) levels were determined. Sensitivity, specificity, positive predictive value and negative predictive value of vitamin D and PTH levels, respectively, in the diagnosis of postoperative hypocalcaemia were calculated. Results: Hypocalcaemia was diagnosed in 44 (38.9%) patients. Vitamin D levels were significantly higher in the group of patients with normal postoperative calcium (median: 25.4. pg/mL; range: 4-60), compared to those who developed hypocalcaemia (median: 16.4. pg/mL; range: 6.3-46.9) (P=.001). Postoperative hypocalcaemia was more frequent in patients with vitamin D < 30. ng/mL (39/78) (50%), than among those with normal levels (5/35) (14.2%) (P=.001). Sensitivity, specificity, positive predictive value and negative predictive value were 88% and 68%, 43% and 82%, 50% and 71%, and 85% and 80% for vitamin D and PTH, respectively. Vitamin D and PTH showed independent prognostic values on the risk of hypocalcaemia. The OR associated with vitamin D < 30. ng/mL was 4.25 (95% CI: 1.31-13.78) (P=.016), and the OR of PTH<13 pg/mL was 15.4 (95% CI: 4.83-49.1) (P<.001). Conclusion: Vitamin D deficiency is a risk factor of hypocalcaemia after total thyroidectomy for benign goitre. The vitamin D level provides independent prognostic information, which is complementary to that given by PTH.

Título traducido de la contribuciónEffect of vitamin D deficiency on hypocalcaemia after total thyroidectomy due to benign goitre
Idioma originalEspañol
Páginas (desde-hasta)250-256
Número de páginas7
PublicaciónCirugia Espanola
Volumen91
N.º4
DOI
EstadoPublicada - abr. 2013
Publicado de forma externa

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  • Cirugía

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