Stent liberadores de medicamento en enfermedad coronaria prematura en jóvenes con hipercolesterolemia familiar homocigota y trasplante hepático previo

Darío Echeverri, Jaime R. Cabrales, Juan Hernando del Portillo, Dairo Rey

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

1 Cita (Scopus)

Resumen

Familial hypercholesterolemia is a genetic disorder characterised by very high cholesterol and low-density lipoproteins serum levels, tendon xanthomas and premature atherosclerosis. Heterozygous form is the most common, with a prevalence of approximately 1 out of 300 to 500 people worldwide, whereas the homozygous, autosomal dominant, is the rarest form, with a prevalence of 1 out of 1 million people. It is characterised by severe hypercholesterolemia leading to premature cardiovascular disease, and it often does not respond to traditional therapy due to the lack of receptors for functional LDL-c. LDL-c levels can exceed between six and ten times the normal values, in which case liver transplantation has become the treatment of choice for patients who do not respond to routine pharmacological therapies. This study presents two cases of homozygous familial hypercholesterolemia in young patients aged 14 and 15, with prior liver transplantation and severe coronary disease in major vessels (anterior descending artery and right coronary artery) who underwent successful implant of a drug-eluting stent.

Título traducido de la contribuciónDrug-eluting stents in premature coronary disease in young people with homozygous familial hypercholesterolemia and prior liver transplantation
Idioma originalEspañol
Páginas (desde-hasta)351-360
Número de páginas10
PublicaciónRevista Colombiana de Cardiologia
Volumen24
N.º4
DOI
EstadoPublicada - jul 1 2017

All Science Journal Classification (ASJC) codes

  • Cardiología y medicina cardiovascular

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