Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review

Jenny Amaya-Amaya, Omar Javier Calixto, Sandra Saade-Lemus, Enrique Calvo-Paramo, Ruben Dario Mantilla, Adriana Rojas-Villarraga, Juan Manuel Anaya

Resultado de la investigación: Contribución a RevistaArtículo

4 Citas (Scopus)

Resumen

© 2014 Elsevier Inc.Objective: To evaluate the prevalence and factors associated with non-erosive rheumatoid arthritis (RA). Methods: First, a cross-sectional analytical study was performed. Non-erosive disease, defined as the absence of any erosion on X-rays after 5 years of RA, was evaluated in 500 patients. Further and additional evaluations including ultrasonography (US) and computed tomography (CT) were performed in those patients meeting the eligibility criteria. The Spearman correlation coefficient, kappa analysis, and Kendall[U+05F3]s W test were used to analyze the data. Second, a systematic literature review (SLR) was performed following the PRISMA guidelines. Results: Of a total of 40 patients meeting the eligibility criteria for non-erosive RA, eight patients were confirmed to have non-erosive RA by the three methods. A positive correlation between non-erosive RA and shorter disease duration, antinuclear antibodies positivity, lower rheumatoid factor (RF) and C-reactive protein titers, lower global visual analog scale values, toxic exposures, and lower disease activity-(RAPID3) was found. In addition, an inverse correlation with anticyclic citrullinated peptide antibodies (ACPA) positivity and medication use was observed. From the SLR, it was corroborated that factors associated with this subphenotype were shorter disease duration, younger disease onset, negative ACPA and RF titers, low cytokine levels, and some genetic markers. Conclusion: Non-erosive RA is rare, occurring in less than 2% of cases. These findings improve on the understanding of RA patients who present without erosions and are likely to have less severe disease.
Idioma originalEnglish (US)
Páginas (desde-hasta)489-498
Número de páginas10
PublicaciónSeminars in Arthritis and Rheumatism
DOI
EstadoPublished - ene 1 2015

Huella dactilar

Rheumatoid Arthritis
Cross-Sectional Studies
Rheumatoid Factor
Peptides
Antibodies
Poisons
Antinuclear Antibodies
Visual Analog Scale
Genetic Markers
C-Reactive Protein
Ultrasonography
Tomography
X-Rays
Guidelines
Cytokines

Citar esto

Amaya-Amaya, J., Calixto, O. J., Saade-Lemus, S., Calvo-Paramo, E., Mantilla, R. D., Rojas-Villarraga, A., & Anaya, J. M. (2015). Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review. Seminars in Arthritis and Rheumatism, 489-498. https://doi.org/10.1016/j.semarthrit.2014.09.006
Amaya-Amaya, Jenny ; Calixto, Omar Javier ; Saade-Lemus, Sandra ; Calvo-Paramo, Enrique ; Mantilla, Ruben Dario ; Rojas-Villarraga, Adriana ; Anaya, Juan Manuel. / Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review. En: Seminars in Arthritis and Rheumatism. 2015 ; pp. 489-498.
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title = "Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review",
abstract = "{\circledC} 2014 Elsevier Inc.Objective: To evaluate the prevalence and factors associated with non-erosive rheumatoid arthritis (RA). Methods: First, a cross-sectional analytical study was performed. Non-erosive disease, defined as the absence of any erosion on X-rays after 5 years of RA, was evaluated in 500 patients. Further and additional evaluations including ultrasonography (US) and computed tomography (CT) were performed in those patients meeting the eligibility criteria. The Spearman correlation coefficient, kappa analysis, and Kendall[U+05F3]s W test were used to analyze the data. Second, a systematic literature review (SLR) was performed following the PRISMA guidelines. Results: Of a total of 40 patients meeting the eligibility criteria for non-erosive RA, eight patients were confirmed to have non-erosive RA by the three methods. A positive correlation between non-erosive RA and shorter disease duration, antinuclear antibodies positivity, lower rheumatoid factor (RF) and C-reactive protein titers, lower global visual analog scale values, toxic exposures, and lower disease activity-(RAPID3) was found. In addition, an inverse correlation with anticyclic citrullinated peptide antibodies (ACPA) positivity and medication use was observed. From the SLR, it was corroborated that factors associated with this subphenotype were shorter disease duration, younger disease onset, negative ACPA and RF titers, low cytokine levels, and some genetic markers. Conclusion: Non-erosive RA is rare, occurring in less than 2{\%} of cases. These findings improve on the understanding of RA patients who present without erosions and are likely to have less severe disease.",
author = "Jenny Amaya-Amaya and Calixto, {Omar Javier} and Sandra Saade-Lemus and Enrique Calvo-Paramo and Mantilla, {Ruben Dario} and Adriana Rojas-Villarraga and Anaya, {Juan Manuel}",
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Amaya-Amaya, J, Calixto, OJ, Saade-Lemus, S, Calvo-Paramo, E, Mantilla, RD, Rojas-Villarraga, A & Anaya, JM 2015, 'Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review', Seminars in Arthritis and Rheumatism, pp. 489-498. https://doi.org/10.1016/j.semarthrit.2014.09.006

Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review. / Amaya-Amaya, Jenny; Calixto, Omar Javier; Saade-Lemus, Sandra; Calvo-Paramo, Enrique; Mantilla, Ruben Dario; Rojas-Villarraga, Adriana; Anaya, Juan Manuel.

En: Seminars in Arthritis and Rheumatism, 01.01.2015, p. 489-498.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Does non-erosive rheumatoid arthritis exist? A cross-sectional analysis and a systematic literature review

AU - Amaya-Amaya, Jenny

AU - Calixto, Omar Javier

AU - Saade-Lemus, Sandra

AU - Calvo-Paramo, Enrique

AU - Mantilla, Ruben Dario

AU - Rojas-Villarraga, Adriana

AU - Anaya, Juan Manuel

PY - 2015/1/1

Y1 - 2015/1/1

N2 - © 2014 Elsevier Inc.Objective: To evaluate the prevalence and factors associated with non-erosive rheumatoid arthritis (RA). Methods: First, a cross-sectional analytical study was performed. Non-erosive disease, defined as the absence of any erosion on X-rays after 5 years of RA, was evaluated in 500 patients. Further and additional evaluations including ultrasonography (US) and computed tomography (CT) were performed in those patients meeting the eligibility criteria. The Spearman correlation coefficient, kappa analysis, and Kendall[U+05F3]s W test were used to analyze the data. Second, a systematic literature review (SLR) was performed following the PRISMA guidelines. Results: Of a total of 40 patients meeting the eligibility criteria for non-erosive RA, eight patients were confirmed to have non-erosive RA by the three methods. A positive correlation between non-erosive RA and shorter disease duration, antinuclear antibodies positivity, lower rheumatoid factor (RF) and C-reactive protein titers, lower global visual analog scale values, toxic exposures, and lower disease activity-(RAPID3) was found. In addition, an inverse correlation with anticyclic citrullinated peptide antibodies (ACPA) positivity and medication use was observed. From the SLR, it was corroborated that factors associated with this subphenotype were shorter disease duration, younger disease onset, negative ACPA and RF titers, low cytokine levels, and some genetic markers. Conclusion: Non-erosive RA is rare, occurring in less than 2% of cases. These findings improve on the understanding of RA patients who present without erosions and are likely to have less severe disease.

AB - © 2014 Elsevier Inc.Objective: To evaluate the prevalence and factors associated with non-erosive rheumatoid arthritis (RA). Methods: First, a cross-sectional analytical study was performed. Non-erosive disease, defined as the absence of any erosion on X-rays after 5 years of RA, was evaluated in 500 patients. Further and additional evaluations including ultrasonography (US) and computed tomography (CT) were performed in those patients meeting the eligibility criteria. The Spearman correlation coefficient, kappa analysis, and Kendall[U+05F3]s W test were used to analyze the data. Second, a systematic literature review (SLR) was performed following the PRISMA guidelines. Results: Of a total of 40 patients meeting the eligibility criteria for non-erosive RA, eight patients were confirmed to have non-erosive RA by the three methods. A positive correlation between non-erosive RA and shorter disease duration, antinuclear antibodies positivity, lower rheumatoid factor (RF) and C-reactive protein titers, lower global visual analog scale values, toxic exposures, and lower disease activity-(RAPID3) was found. In addition, an inverse correlation with anticyclic citrullinated peptide antibodies (ACPA) positivity and medication use was observed. From the SLR, it was corroborated that factors associated with this subphenotype were shorter disease duration, younger disease onset, negative ACPA and RF titers, low cytokine levels, and some genetic markers. Conclusion: Non-erosive RA is rare, occurring in less than 2% of cases. These findings improve on the understanding of RA patients who present without erosions and are likely to have less severe disease.

U2 - 10.1016/j.semarthrit.2014.09.006

DO - 10.1016/j.semarthrit.2014.09.006

M3 - Article

SP - 489

EP - 498

JO - Seminars in Arthritis and Rheumatism

JF - Seminars in Arthritis and Rheumatism

SN - 0049-0172

ER -