Distribution patterns of infection with multiple types of human papillomaviruses and their association with risk factors

Sara Soto-De Leon, Milena Camargo, Ricardo Sanchez, Marina Munoz, Antonio Perez-Prados, Antonio Purroy, Manuel Elkin Patarroyo, Manuel Alfonso Patarroyo

Resultado de la investigación: Contribución a RevistaArtículo

27 Citas (Scopus)

Resumen

Background: Infection with multiple types of human papillomavirus (HPV) is one of the main risk factors associated with the development of cervical lesions. In this study, cervical samples collected from 1,810 women with diverse sociocultural backgrounds, who attended to their cervical screening program in different geographical regions of Colombia, were examined for the presence of cervical lesions and HPV by Papanicolau testing and DNA PCR detection, respectively. Principal Findings: The negative binomial distribution model used in this study showed differences between the observed and expected values within some risk factor categories analyzed. Particularly in the case of single infection and coinfection with more than 4 HPV types, observed frequencies were smaller than expected, while the number of women infected with 2 to 4 viral types were higher than expected. Data analysis according to a negative binomial regression showed an increase in the risk of acquiring more HPV types in women who were of indigenous ethnicity (+37.8%), while this risk decreased in women who had given birth more than 4 times (-31.1%), or were of mestizo (-24.6%) or black (-40.9%) ethnicity. Conclusions: According to a theoretical probability distribution, the observed number of women having either a single infection or more than 4 viral types was smaller than expected, while for those infected with 2-4HPV types it was larger than expected. Taking into account that this study showed a higher HPV coinfection rate in the indigenous ethnicity, the role of underlying factors should be assessed in detail in future studies. © 2011 Soto-De Leon et al.
Idioma originalEnglish (US)
PublicaciónPLoS One
DOI
EstadoPublished - feb 28 2011

Huella dactilar

Papillomaviridae
risk factors
nationalities and ethnic groups
Infection
infection
Coinfection
mixed infection
Human papillomavirus 4
lesions (animal)
Gammapapillomavirus
Geographical regions
Binomial Distribution
Colombia
Probability distributions
risk reduction
probability distribution
Statistical Models
Screening
data analysis
Parturition

Citar esto

Soto-De Leon, Sara ; Camargo, Milena ; Sanchez, Ricardo ; Munoz, Marina ; Perez-Prados, Antonio ; Purroy, Antonio ; Patarroyo, Manuel Elkin ; Patarroyo, Manuel Alfonso. / Distribution patterns of infection with multiple types of human papillomaviruses and their association with risk factors. En: PLoS One. 2011.
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title = "Distribution patterns of infection with multiple types of human papillomaviruses and their association with risk factors",
abstract = "Background: Infection with multiple types of human papillomavirus (HPV) is one of the main risk factors associated with the development of cervical lesions. In this study, cervical samples collected from 1,810 women with diverse sociocultural backgrounds, who attended to their cervical screening program in different geographical regions of Colombia, were examined for the presence of cervical lesions and HPV by Papanicolau testing and DNA PCR detection, respectively. Principal Findings: The negative binomial distribution model used in this study showed differences between the observed and expected values within some risk factor categories analyzed. Particularly in the case of single infection and coinfection with more than 4 HPV types, observed frequencies were smaller than expected, while the number of women infected with 2 to 4 viral types were higher than expected. Data analysis according to a negative binomial regression showed an increase in the risk of acquiring more HPV types in women who were of indigenous ethnicity (+37.8{\%}), while this risk decreased in women who had given birth more than 4 times (-31.1{\%}), or were of mestizo (-24.6{\%}) or black (-40.9{\%}) ethnicity. Conclusions: According to a theoretical probability distribution, the observed number of women having either a single infection or more than 4 viral types was smaller than expected, while for those infected with 2-4HPV types it was larger than expected. Taking into account that this study showed a higher HPV coinfection rate in the indigenous ethnicity, the role of underlying factors should be assessed in detail in future studies. {\circledC} 2011 Soto-De Leon et al.",
author = "{Soto-De Leon}, Sara and Milena Camargo and Ricardo Sanchez and Marina Munoz and Antonio Perez-Prados and Antonio Purroy and Patarroyo, {Manuel Elkin} and Patarroyo, {Manuel Alfonso}",
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Distribution patterns of infection with multiple types of human papillomaviruses and their association with risk factors. / Soto-De Leon, Sara; Camargo, Milena; Sanchez, Ricardo; Munoz, Marina; Perez-Prados, Antonio; Purroy, Antonio; Patarroyo, Manuel Elkin; Patarroyo, Manuel Alfonso.

En: PLoS One, 28.02.2011.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Distribution patterns of infection with multiple types of human papillomaviruses and their association with risk factors

AU - Soto-De Leon, Sara

AU - Camargo, Milena

AU - Sanchez, Ricardo

AU - Munoz, Marina

AU - Perez-Prados, Antonio

AU - Purroy, Antonio

AU - Patarroyo, Manuel Elkin

AU - Patarroyo, Manuel Alfonso

PY - 2011/2/28

Y1 - 2011/2/28

N2 - Background: Infection with multiple types of human papillomavirus (HPV) is one of the main risk factors associated with the development of cervical lesions. In this study, cervical samples collected from 1,810 women with diverse sociocultural backgrounds, who attended to their cervical screening program in different geographical regions of Colombia, were examined for the presence of cervical lesions and HPV by Papanicolau testing and DNA PCR detection, respectively. Principal Findings: The negative binomial distribution model used in this study showed differences between the observed and expected values within some risk factor categories analyzed. Particularly in the case of single infection and coinfection with more than 4 HPV types, observed frequencies were smaller than expected, while the number of women infected with 2 to 4 viral types were higher than expected. Data analysis according to a negative binomial regression showed an increase in the risk of acquiring more HPV types in women who were of indigenous ethnicity (+37.8%), while this risk decreased in women who had given birth more than 4 times (-31.1%), or were of mestizo (-24.6%) or black (-40.9%) ethnicity. Conclusions: According to a theoretical probability distribution, the observed number of women having either a single infection or more than 4 viral types was smaller than expected, while for those infected with 2-4HPV types it was larger than expected. Taking into account that this study showed a higher HPV coinfection rate in the indigenous ethnicity, the role of underlying factors should be assessed in detail in future studies. © 2011 Soto-De Leon et al.

AB - Background: Infection with multiple types of human papillomavirus (HPV) is one of the main risk factors associated with the development of cervical lesions. In this study, cervical samples collected from 1,810 women with diverse sociocultural backgrounds, who attended to their cervical screening program in different geographical regions of Colombia, were examined for the presence of cervical lesions and HPV by Papanicolau testing and DNA PCR detection, respectively. Principal Findings: The negative binomial distribution model used in this study showed differences between the observed and expected values within some risk factor categories analyzed. Particularly in the case of single infection and coinfection with more than 4 HPV types, observed frequencies were smaller than expected, while the number of women infected with 2 to 4 viral types were higher than expected. Data analysis according to a negative binomial regression showed an increase in the risk of acquiring more HPV types in women who were of indigenous ethnicity (+37.8%), while this risk decreased in women who had given birth more than 4 times (-31.1%), or were of mestizo (-24.6%) or black (-40.9%) ethnicity. Conclusions: According to a theoretical probability distribution, the observed number of women having either a single infection or more than 4 viral types was smaller than expected, while for those infected with 2-4HPV types it was larger than expected. Taking into account that this study showed a higher HPV coinfection rate in the indigenous ethnicity, the role of underlying factors should be assessed in detail in future studies. © 2011 Soto-De Leon et al.

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DO - 10.1371/journal.pone.0014705

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JO - PLoS One

JF - PLoS One

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