Discovery of novel heart rate-associated loci using the Exome Chip

Marten E. Van Den Berg, Helen R. Warren, Claudia P. Cabrera, Niek Verweij, Borbala Mifsud, Jeffrey Haessler, Nathan A. Bihlmeyer, Yi Ping Fu, Stefan Weiss, Henry J. Lin, Niels Grarup, Ruifang Li-Gao, Giorgio Pistis, Nabi Shah, Jennifer A. Brody, Martina Müller-Nurasyid, Honghuang Lin, Hao Mei, Albert V. Smith, Leo Pekka LyytikäinenLeanne M. Hall, Jessica Van Setten, Stella Trompet, Bram P. Prins, Aaron Isaacs, Farid Radmanesh, Jonathan Marten, Aiman Entwistle, Jan A. Kors, Claudia T. Silva, Alvaro Alonso, Joshua C. Bis, Rudolf De Boer, Hugoline G. De Haan, Renée De Mutsert, George Dedoussis, Anna F. Dominiczak, Alex S.F. Doney, Patrick T. Ellinor, Ruben N. Eppinga, Stephan B. Felix, Xiuqing Guo, Yanick Hagemeijer, Torben Hansen, Tamara B. Harris, Susan R. Heckbert, Paul L. Huang, Shih Jen Hwang, Mika Kähönen, Jørgen K. Kanters

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

25 Citas (Scopus)

Resumen

Resting heart rate is a heritable trait, and an increase in heart rate is associated with increased mortality risk. Genome-wide association study analyses have found loci associated with resting heart rate, at the time of our study these loci explained 0.9% of the variation. This study aims to discover new genetic loci associated with heart rate from Exome Chip meta-analyses.

Heart rate was measured from either elecrtrocardiograms or pulse recordings. We meta-analysed heart rate association results from 104 452 European-ancestry individuals from 30 cohorts, genotyped using the Exome Chip. Twenty-four variants were selected for follow-up in an independent dataset (UK Biobank, N = 134 251). Conditional and gene-based testing was undertaken, and variants were investigated with bioinformatics methods.
Idioma originalInglés estadounidense
Páginas (desde-hasta)2346-2363
Número de páginas18
PublicaciónHuman Molecular Genetics
Volumen26
N.º12
DOI
EstadoPublicada - jun. 15 2017

Áreas temáticas de ASJC Scopus

  • Biología molecular
  • Genética
  • Genética (clínica)

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