Difficulties during delivery, brain ventricle enlargement and cognitive impairment in first episode psychosis

doi:10.1017/S0033291723003185

Difficulties during delivery, brain ventricle enlargement and cognitive impairment in first episode psychosis

Título traducido de la contribución: Dificultades durante el parto, agrandamiento del ventrículo cerebral y deterioro cognitivo en la psicosis de primer episodio

Producción científica: Contribución a una revista › Artículo de Investigación › revisión exhaustiva

2 Citas (Scopus)

Resumen

Antecedentes: Los pacientes con un primer episodio de psicosis (PEP) presentan anomalías clínicas, cognitivas y estructurales cerebrales al inicio de la enfermedad. El agrandamiento ventricular se ha identificado en la esquizofrenia desde el desarrollo inicial de las técnicas de neuroimagen. Las anomalías obstétricas se han asociado con un mayor riesgo de desarrollar psicosis, pero también con deterioro cognitivo y anomalías de la estructura cerebral. Las dificultades durante el parto se asocian con un mayor riesgo de asfixia al nacer que conduce a anomalías estructurales cerebrales, como la ventriculomegalia, que se ha relacionado con alteraciones cognitivas.

Métodos: Se examinaron las diferencias de tamaño ventricular entre 142 pacientes con FEP y 123 participantes sanos de control mediante resonancia magnética. Las complicaciones obstétricas se evaluaron mediante la escala de Lewis-Murray. Se examinó el impacto de las dificultades obstétricas durante el parto en el tamaño ventricular, así como la posible relación entre el tamaño ventricular y las alteraciones cognitivas en ambos grupos.

Resultados: Los pacientes con FEP mostraron un tamaño del tercer ventrículo significativamente mayor en comparación con los controles sanos. El agrandamiento del tercer ventrículo se asoció con el diagnóstico (mayor volumen en las pacientes), con las dificultades durante el parto (mayor volumen en los sujetos con dificultades) y fue mayor en las pacientes con dificultades durante el parto. La memoria verbal se asoció significativamente con la relación entre el tercer ventrículo y el cerebro.

Conclusiones: Nuestros resultados sugieren que las dificultades durante el parto podrían contribuir significativamente al agrandamiento ventricular descrito históricamente en la esquizofrenia. Así pues, las complicaciones obstétricas pueden contribuir al desarrollo de la psicosis a través de cambios en la arquitectura cerebral.

Título traducido de la contribución	Dificultades durante el parto, agrandamiento del ventrículo cerebral y deterioro cognitivo en la psicosis de primer episodio
Idioma original	Inglés estadounidense
Publicación	Psychological Medicine
DOI	https://doi.org/10.1017/S0033291723003185
Estado	Publicación electrónica previa a su impresión - nov. 28 2023

Áreas temáticas de ASJC Scopus

Psicología aplicada
Psiquiatría y salud mental

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Acceder al documento

10.1017/S0033291723003185

Otros archivos y enlaces

Citar esto

@article{0b02f06773404ff1b78dfb87acecdd3a,

title = "Difficulties during delivery, brain ventricle enlargement and cognitive impairment in first episode psychosis",

abstract = "Background Patients with a first episode of psychosis (FEP) display clinical, cognitive, and structural brain abnormalities at illness onset. Ventricular enlargement has been identified in schizophrenia since the initial development of neuroimaging techniques. Obstetric abnormalities have been associated with an increased risk of developing psychosis but also with cognitive impairment and brain structure abnormalities. Difficulties during delivery are associated with a higher risk of birth asphyxia leading to brain structural abnormalities, such as ventriculomegaly, which has been related to cognitive disturbances. Methods We examined differences in ventricular size between 142 FEP patients and 123 healthy control participants using magnetic resonance imaging. Obstetric complications were evaluated using the Lewis-Murray scale. We examined the impact of obstetric difficulties during delivery on ventricle size as well as the possible relationship between ventricle size and cognitive impairment in both groups. Results FEP patients displayed significantly larger third ventricle size compared with healthy controls. Third ventricle enlargement was associated with diagnosis (higher volume in patients), with difficulties during delivery (higher volume in subjects with difficulties), and was highest in patients with difficulties during delivery. Verbal memory was significantly associated with third ventricle to brain ratio. Conclusions Our results suggest that difficulties during delivery might be significant contributors to the ventricular enlargement historically described in schizophrenia. Thus, obstetric complications may contribute to the development of psychosis through changes in brain architecture.",

author = "Ana Costas-Carrera and Norma Verdolini and Clemente Garcia-Rizo and Gisela Mezquida and Joost Janssen and Isabel Valli and Iluminada Corripio and Sanchez-Torres, {Ana M.} and Miquel Bioque and Antonio Lobo and Ana Gonzalez-Pinto and Marta Rapado-Castro and Eduard Vieta and {De La Serna}, Helena and Anna Mane and Alexandra Roldan and Nicolas Crossley and Rafael Penades and Cuesta, {Manuel J.} and Mara Parellada and Miquel Bernardo and Forte, {M. Florencia} and Gonzalez-Diaz, {Jairo M.} and Vito Cavone and Celia Ordas and I{\~n}aki Zorrilla and Saioa Lopez-Zurbano and {De La Camara}, Concepcion and Puyuelo, {David Vaquero} and Juan Nacher and Fabra, {Maria Jos{\'e} Escart{\'i}} and Privat, {Alba Toll} and Sadurn{\'i}, {Laura Mart{\'i}nez} and Sara Mart{\'i}n-Parra and Derek Clougher and Inmaculada Baeza and J. Castro-Fornielles and Fernando Contreras and Garc{\'i}a-Portilla, {M. Paz} and Leticia Gonz{\'a}lez-Blanco and Roberto Rodriguez-Jimenez and {\'A}ngeles S{\'a}nchez-Cabezudo and Judith Usall and Anna Butjosa and Salvador Sarro and Edith Pomarol-Clotet and Judit Selma and Aina {\`A}vila-Parcet and Mar{\'i}a Ribeiro",

note = "Publisher Copyright: {\textcopyright} The Author(s), 2023. Published by Cambridge University Press.",

year = "2023",

month = nov,

day = "28",

doi = "10.1017/S0033291723003185",

language = "English (US)",

journal = "Psychological Medicine",

issn = "0033-2917",

publisher = "Cambridge University Press",

}

TY - JOUR

T1 - Difficulties during delivery, brain ventricle enlargement and cognitive impairment in first episode psychosis

AU - Costas-Carrera, Ana

AU - Verdolini, Norma

AU - Garcia-Rizo, Clemente

AU - Mezquida, Gisela

AU - Janssen, Joost

AU - Valli, Isabel

AU - Corripio, Iluminada

AU - Sanchez-Torres, Ana M.

AU - Bioque, Miquel

AU - Lobo, Antonio

AU - Gonzalez-Pinto, Ana

AU - Rapado-Castro, Marta

AU - Vieta, Eduard

AU - De La Serna, Helena

AU - Mane, Anna

AU - Roldan, Alexandra

AU - Crossley, Nicolas

AU - Penades, Rafael

AU - Cuesta, Manuel J.

AU - Parellada, Mara

AU - Bernardo, Miquel

AU - Forte, M. Florencia

AU - Gonzalez-Diaz, Jairo M.

AU - Cavone, Vito

AU - Ordas, Celia

AU - Zorrilla, Iñaki

AU - Lopez-Zurbano, Saioa

AU - De La Camara, Concepcion

AU - Puyuelo, David Vaquero

AU - Nacher, Juan

AU - Fabra, Maria José Escartí

AU - Privat, Alba Toll

AU - Sadurní, Laura Martínez

AU - Martín-Parra, Sara

AU - Clougher, Derek

AU - Baeza, Inmaculada

AU - Castro-Fornielles, J.

AU - Contreras, Fernando

AU - García-Portilla, M. Paz

AU - González-Blanco, Leticia

AU - Rodriguez-Jimenez, Roberto

AU - Sánchez-Cabezudo, Ángeles

AU - Usall, Judith

AU - Butjosa, Anna

AU - Sarro, Salvador

AU - Pomarol-Clotet, Edith

AU - Selma, Judit

AU - Àvila-Parcet, Aina

AU - Ribeiro, María

PY - 2023/11/28

Y1 - 2023/11/28

N2 - Background Patients with a first episode of psychosis (FEP) display clinical, cognitive, and structural brain abnormalities at illness onset. Ventricular enlargement has been identified in schizophrenia since the initial development of neuroimaging techniques. Obstetric abnormalities have been associated with an increased risk of developing psychosis but also with cognitive impairment and brain structure abnormalities. Difficulties during delivery are associated with a higher risk of birth asphyxia leading to brain structural abnormalities, such as ventriculomegaly, which has been related to cognitive disturbances. Methods We examined differences in ventricular size between 142 FEP patients and 123 healthy control participants using magnetic resonance imaging. Obstetric complications were evaluated using the Lewis-Murray scale. We examined the impact of obstetric difficulties during delivery on ventricle size as well as the possible relationship between ventricle size and cognitive impairment in both groups. Results FEP patients displayed significantly larger third ventricle size compared with healthy controls. Third ventricle enlargement was associated with diagnosis (higher volume in patients), with difficulties during delivery (higher volume in subjects with difficulties), and was highest in patients with difficulties during delivery. Verbal memory was significantly associated with third ventricle to brain ratio. Conclusions Our results suggest that difficulties during delivery might be significant contributors to the ventricular enlargement historically described in schizophrenia. Thus, obstetric complications may contribute to the development of psychosis through changes in brain architecture.

AB - Background Patients with a first episode of psychosis (FEP) display clinical, cognitive, and structural brain abnormalities at illness onset. Ventricular enlargement has been identified in schizophrenia since the initial development of neuroimaging techniques. Obstetric abnormalities have been associated with an increased risk of developing psychosis but also with cognitive impairment and brain structure abnormalities. Difficulties during delivery are associated with a higher risk of birth asphyxia leading to brain structural abnormalities, such as ventriculomegaly, which has been related to cognitive disturbances. Methods We examined differences in ventricular size between 142 FEP patients and 123 healthy control participants using magnetic resonance imaging. Obstetric complications were evaluated using the Lewis-Murray scale. We examined the impact of obstetric difficulties during delivery on ventricle size as well as the possible relationship between ventricle size and cognitive impairment in both groups. Results FEP patients displayed significantly larger third ventricle size compared with healthy controls. Third ventricle enlargement was associated with diagnosis (higher volume in patients), with difficulties during delivery (higher volume in subjects with difficulties), and was highest in patients with difficulties during delivery. Verbal memory was significantly associated with third ventricle to brain ratio. Conclusions Our results suggest that difficulties during delivery might be significant contributors to the ventricular enlargement historically described in schizophrenia. Thus, obstetric complications may contribute to the development of psychosis through changes in brain architecture.

UR - http://www.scopus.com/inward/record.url?scp=85179109824&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85179109824&partnerID=8YFLogxK

U2 - 10.1017/S0033291723003185

DO - 10.1017/S0033291723003185

M3 - Research Article

C2 - 38014924

AN - SCOPUS:85179109824

SN - 0033-2917

JO - Psychological Medicine

JF - Psychological Medicine

ER -

Difficulties during delivery, brain ventricle enlargement and cognitive impairment in first episode psychosis

Resumen

Áreas temáticas de ASJC Scopus

ODS de las Naciones Unidas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto