Differences in the cerebral hemodynamics regulation mechanisms of premature infants with intra-ventricular hemorrhage assessed by means of phase rectified signal averaging

Alexander Caicedo, Carolina Varon, Thomas Alderliesten, Petra Lemmers, Frank Van Bel, Gunnar Naulaers, Sabine Van Huffel

Resultado de la investigación: Capítulo en Libro/Reporte/ConferenciaContribución a la conferencia

6 Citas (Scopus)

Resumen

Cerebral hemodynamics regulation consists of several mechanisms that try to keep brain homeostasis. In premature infants, due to the immaturity of their cerebral vascular bed, these mechanisms might be impaired exposing their brain to damage. The status of the cerebral regulation mechanism is classically assessed by measuring the coupling between some systemic variables, such as Mean arterial blood pressure (MABP) and concentration of blood gases, with surrogate measurements for cerebral blood flow, such as brain tissue oxygenation (rScO2) measured by means of Near-infrared Spectroscopy. We hypothesized that the coupled dynamics between systemic variables and rScO2 is different in premature infants that suffered from brain damage than in those with a favorable clinical outcome. Therefore, we explore the use of phase rectified signal averaging (PRSA) and bi-variate PRSA (BPRSA) in order to identify these differences. We found that the coupled dynamics between changes in MABP and cerebral oxygenation was different in premature infants that suffered III-IV grade intra-ventricular haemorrhage (IVH), when compared to control subjects.

Idioma originalInglés estadounidense
Título de la publicación alojada2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
EditorialInstitute of Electrical and Electronics Engineers Inc.
Páginas4208-4211
Número de páginas4
ISBN (versión digital)9781424479290
DOI
EstadoPublicada - nov 2 2014
Publicado de forma externa
Evento2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 - Chicago, Estados Unidos
Duración: ago 26 2014ago 30 2014

Serie de la publicación

Nombre2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014

Conferencia

Conferencia2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
País/TerritorioEstados Unidos
CiudadChicago
Período8/26/148/30/14

All Science Journal Classification (ASJC) codes

  • Informática aplicada a la salud
  • Informática aplicada
  • Ingeniería biomédica
  • Medicina (todo)

Huella

Profundice en los temas de investigación de 'Differences in the cerebral hemodynamics regulation mechanisms of premature infants with intra-ventricular hemorrhage assessed by means of phase rectified signal averaging'. En conjunto forman una huella única.

Citar esto