Differences in planning performance, a neurocognitive endophenotype, are associated with a functional variant in PER3 gene

Yeimy González-Giraldo, Rodrigo E. González-Reyes, Shane T. Mueller, Brian J. Piper, Ana Adan, Diego A. Forero

Resultado de la investigación: Contribución a RevistaArtículo

8 Citas (Scopus)

Resumen

Performance alterations in executive function have been studied as potential endophenotypes for several neuropsychiatric diseases. Planning is an important component of executive function and has been shown to be affected in diseases such as attention deficit hyperactivity disorder, schizophrenia, obsessive-compulsive disorder and Parkinson's disease. Several genes related to dopaminergic systems, such as COMT, have been explored as candidates for influencing planning performance. The circadian clock gene PERIOD3 (PER3) has been shown to be associated with several complex behaviors in humans and could be involved in different signaling mechanisms. In this study, we evaluated the possible association between a functional polymorphism in the PER3 gene (PER3-VNTR, rs57875989) and performance in a commonly used test of planning (Tower of London, TOL) in 229 healthy subjects from Bogotá, Colombia. PER3-VNTR genotyping was carried out with conventional PCR and all participants completed the TOL test using the computerized Psychology Experiment Building Language (PEBL) battery. A linear regression model was used for the analysis of association with the SNPStats program. We found that 4/4 genotype carriers showed a better performance and made fewer moves, in comparison to 4/5 and 5/5 genotype carriers (p=0.003). These results appear to be independent from effects of this polymorphism on self-reported average hours of sleep during work days in our sample. This is the first evidence of an association between PER3-VNTR and planning performance in a sample of healthy subjects and our results are consistent from previous findings for alterations in other cognitive domains. Future studies examining additional genes could lead to the identification of novel molecular underpinnings of planning in healthy subjects and in patients with neuropsychiatric disorders.

Idioma originalEnglish (US)
Páginas (desde-hasta)591-595
Número de páginas5
PublicaciónChronobiology International
Volumen32
N.º5
DOI
EstadoPublished - jun 1 2015
Publicado de forma externa

Huella dactilar

Endophenotypes
Healthy Volunteers
Executive Function
Genes
Linear Models
Genotype
Circadian Clocks
Colombia
Obsessive-Compulsive Disorder
Attention Deficit Disorder with Hyperactivity
Parkinson Disease
Schizophrenia
Sleep
Language
Psychology
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Citar esto

González-Giraldo, Yeimy ; González-Reyes, Rodrigo E. ; Mueller, Shane T. ; Piper, Brian J. ; Adan, Ana ; Forero, Diego A. / Differences in planning performance, a neurocognitive endophenotype, are associated with a functional variant in PER3 gene. En: Chronobiology International. 2015 ; Vol. 32, N.º 5. pp. 591-595.
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abstract = "Performance alterations in executive function have been studied as potential endophenotypes for several neuropsychiatric diseases. Planning is an important component of executive function and has been shown to be affected in diseases such as attention deficit hyperactivity disorder, schizophrenia, obsessive-compulsive disorder and Parkinson's disease. Several genes related to dopaminergic systems, such as COMT, have been explored as candidates for influencing planning performance. The circadian clock gene PERIOD3 (PER3) has been shown to be associated with several complex behaviors in humans and could be involved in different signaling mechanisms. In this study, we evaluated the possible association between a functional polymorphism in the PER3 gene (PER3-VNTR, rs57875989) and performance in a commonly used test of planning (Tower of London, TOL) in 229 healthy subjects from Bogot{\'a}, Colombia. PER3-VNTR genotyping was carried out with conventional PCR and all participants completed the TOL test using the computerized Psychology Experiment Building Language (PEBL) battery. A linear regression model was used for the analysis of association with the SNPStats program. We found that 4/4 genotype carriers showed a better performance and made fewer moves, in comparison to 4/5 and 5/5 genotype carriers (p=0.003). These results appear to be independent from effects of this polymorphism on self-reported average hours of sleep during work days in our sample. This is the first evidence of an association between PER3-VNTR and planning performance in a sample of healthy subjects and our results are consistent from previous findings for alterations in other cognitive domains. Future studies examining additional genes could lead to the identification of novel molecular underpinnings of planning in healthy subjects and in patients with neuropsychiatric disorders.",
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Differences in planning performance, a neurocognitive endophenotype, are associated with a functional variant in PER3 gene. / González-Giraldo, Yeimy; González-Reyes, Rodrigo E.; Mueller, Shane T.; Piper, Brian J.; Adan, Ana; Forero, Diego A.

En: Chronobiology International, Vol. 32, N.º 5, 01.06.2015, p. 591-595.

Resultado de la investigación: Contribución a RevistaArtículo

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