Diabetes Mellitus Type 1 has a Higher Impact on Corneal Endothelial Cell Density and Pachymetry than Diabetes Mellitus Type 2, Independent of Age: A Meta-Regression Model

Diana Patricia Amador-Muñoz; Valentina Conforti; Luisa Marina Matheus; Nicolas Molano-Gonzalez; César Payán-Gómez

doi:10.1097/ICO.0000000000002841

Diabetes Mellitus Type 1 has a Higher Impact on Corneal Endothelial Cell Density and Pachymetry than Diabetes Mellitus Type 2, Independent of Age: A Meta-Regression Model

Diana Patricia Amador-Muñoz, Valentina Conforti, Luisa Marina Matheus, Nicolas Molano-Gonzalez, César Payán-Gómez

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Objetivo:Los pacientes con diabetes mellitus (DM) a menudo presentan queratopatía. Sinembargo, el compromiso del endotelio corneal en la DM tipo 1 (T1DM) y tipo 2(T2DM) hasta el momento no ha sido bien caracterizado.

Metodología: Se realizó una búsqueda bibliográficasistemática para encontrar artículos en humanos que combinaran DM1 y/o DM2 y elendotelio corneal. El período analizado fue desde la fecha de publicación delartículo original hasta junio de 2020. El análisis de meta-regresión evaluó elpapel de cada tipo de DM en la densidad de células endoteliales de la córnea (DCE)y la paquimetría. Los modelos estadísticos incluyeron la edad como moduladorpara discriminar entre los cambios normales debidos a la edad y el efecto de laenfermedad, y determinar el impacto de la duración de la enfermedad.

Resultados: La búsqueda inicial identificó 752registros, de los cuales 17 fueron incluidos en la meta-regresión. Lospacientes con DM1 tenían, en promedio, 193 células/mm2 menos que lospacientes control (P < 0,00001). Los pacientes con DM2 tenían 151 células/mm2menos en comparación con los pacientes control (P < 0,00001). Se esperaba lapérdida de células endoteliales de la córnea puesto que el envejecimiento fuesimilar en pacientes con DM1 y DM2, y sus grupos de control. Los pacientes conDM1 y DM2 mostraron un aumento de la paquimetría frente a los pacientescontrol, y en ambos grupos se asoció este aumento con la duración de laenfermedad.

Conclusiones: Ambos tipos de DM redujeron la densidaddel endotelio corneal y aumentaron la paquimetría. Estas diferencias fueronmayores en pacientes con DM1 versus pacientes control que en pacientes con DM2versus pacientes control. En T1DM, la reducción de DCE no se correlacionó conel tiempo transcurrido desde el diagnóstico de la enfermedad. En ambos grupos,los pacientes tuvieron una reducción de DCE debido al envejecimiento similar ala de los pacientes control.

Idioma original	Inglés estadounidense
Páginas (desde-hasta)	1
Número de páginas	9
Publicación	Cornea
Volumen	41
N.º	8
DOI	https://doi.org/10.1097/ICO.0000000000002841
Estado	Publicación electrónica previa a su impresión - ago. 2022

Áreas temáticas de ASJC Scopus

Endocrinología, diabetes y metabolismo

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

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10.1097/ICO.0000000000002841

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@article{2f87eb6d01b840109b2bacb6d31b3ff7,

title = "Diabetes Mellitus Type 1 has a Higher Impact on Corneal Endothelial Cell Density and Pachymetry than Diabetes Mellitus Type 2, Independent of Age: A Meta-Regression Model",

abstract = "PURPOSE: Patients with diabetes mellitus (DM) often have keratopathy. However, the compromise of the corneal endothelium in type 1 DM (T1DM) and type 2 DM (T2DM) has so far not been well characterized.METHODS: We performed a systematic literature search to find articles on humans combining T1DM and/or T2DM and the corneal endothelium. The period was from inception to June 2020. The meta-regression evaluated the role of each type of DM on corneal endothelial cell density (CED) and pachymetry. The statistical models included age as a modulator to discriminate between the normal changes due to age and the effect of the disease and to determine the impact of the disease duration.RESULTS: The initial search identified 752 records, of which 17 were included in the meta-regression. Patients with T1DM had, on average, 193 cells/mm2 lesser than control patients (P < 0.00001). Patients with T2DM had 151 cells/mm2 less compared with control patients (P < 0.00001). The loss of corneal endothelial cells was expected because the aging was similar in patients with T1DM and T2DM and their control groups. Patients with T1DM and T2DM showed an increase in pachymetry versus control patients, and in both groups, it was associated with the duration of the disease.CONCLUSIONS: Both types of DM reduced CED and increased pachymetry. These differences were higher in patients with T1DM versus control patients than patients with T2DM versus control patients. In T1DM, CED reduction was not correlated with the time from diagnosis. In both groups, patients had CED reduction due to aging similar to that of their matched control patients.",

author = "Amador-Mu{\~n}oz, {Diana Patricia} and Valentina Conforti and Matheus, {Luisa Marina} and Nicolas Molano-Gonzalez and C{\'e}sar Pay{\'a}n-G{\'o}mez",

year = "2022",

month = aug,

doi = "10.1097/ICO.0000000000002841",

language = "English (US)",

volume = "41",

pages = "1",

journal = "Cornea",

issn = "0277-3740",

publisher = "Lippincott Williams and Wilkins",

number = "8",

}

Diabetes Mellitus Type 1 has a Higher Impact on Corneal Endothelial Cell Density and Pachymetry than Diabetes Mellitus Type 2, Independent of Age: A Meta-Regression Model. / Amador-Muñoz, Diana Patricia; Conforti, Valentina; Matheus, Luisa Marina et al.
En: Cornea, Vol. 41, N.º 8, 08.2022, p. 1.

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

TY - JOUR

T1 - Diabetes Mellitus Type 1 has a Higher Impact on Corneal Endothelial Cell Density and Pachymetry than Diabetes Mellitus Type 2, Independent of Age

T2 - A Meta-Regression Model

AU - Amador-Muñoz, Diana Patricia

AU - Conforti, Valentina

AU - Matheus, Luisa Marina

AU - Molano-Gonzalez, Nicolas

AU - Payán-Gómez, César

PY - 2022/8

Y1 - 2022/8

N2 - PURPOSE: Patients with diabetes mellitus (DM) often have keratopathy. However, the compromise of the corneal endothelium in type 1 DM (T1DM) and type 2 DM (T2DM) has so far not been well characterized.METHODS: We performed a systematic literature search to find articles on humans combining T1DM and/or T2DM and the corneal endothelium. The period was from inception to June 2020. The meta-regression evaluated the role of each type of DM on corneal endothelial cell density (CED) and pachymetry. The statistical models included age as a modulator to discriminate between the normal changes due to age and the effect of the disease and to determine the impact of the disease duration.RESULTS: The initial search identified 752 records, of which 17 were included in the meta-regression. Patients with T1DM had, on average, 193 cells/mm2 lesser than control patients (P < 0.00001). Patients with T2DM had 151 cells/mm2 less compared with control patients (P < 0.00001). The loss of corneal endothelial cells was expected because the aging was similar in patients with T1DM and T2DM and their control groups. Patients with T1DM and T2DM showed an increase in pachymetry versus control patients, and in both groups, it was associated with the duration of the disease.CONCLUSIONS: Both types of DM reduced CED and increased pachymetry. These differences were higher in patients with T1DM versus control patients than patients with T2DM versus control patients. In T1DM, CED reduction was not correlated with the time from diagnosis. In both groups, patients had CED reduction due to aging similar to that of their matched control patients.

AB - PURPOSE: Patients with diabetes mellitus (DM) often have keratopathy. However, the compromise of the corneal endothelium in type 1 DM (T1DM) and type 2 DM (T2DM) has so far not been well characterized.METHODS: We performed a systematic literature search to find articles on humans combining T1DM and/or T2DM and the corneal endothelium. The period was from inception to June 2020. The meta-regression evaluated the role of each type of DM on corneal endothelial cell density (CED) and pachymetry. The statistical models included age as a modulator to discriminate between the normal changes due to age and the effect of the disease and to determine the impact of the disease duration.RESULTS: The initial search identified 752 records, of which 17 were included in the meta-regression. Patients with T1DM had, on average, 193 cells/mm2 lesser than control patients (P < 0.00001). Patients with T2DM had 151 cells/mm2 less compared with control patients (P < 0.00001). The loss of corneal endothelial cells was expected because the aging was similar in patients with T1DM and T2DM and their control groups. Patients with T1DM and T2DM showed an increase in pachymetry versus control patients, and in both groups, it was associated with the duration of the disease.CONCLUSIONS: Both types of DM reduced CED and increased pachymetry. These differences were higher in patients with T1DM versus control patients than patients with T2DM versus control patients. In T1DM, CED reduction was not correlated with the time from diagnosis. In both groups, patients had CED reduction due to aging similar to that of their matched control patients.

U2 - 10.1097/ICO.0000000000002841

DO - 10.1097/ICO.0000000000002841

M3 - Article

C2 - 34561313

SN - 0277-3740

VL - 41

SP - 1

JO - Cornea

JF - Cornea

IS - 8

ER -

Diabetes Mellitus Type 1 has a Higher Impact on Corneal Endothelial Cell Density and Pachymetry than Diabetes Mellitus Type 2, Independent of Age: A Meta-Regression Model

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