Development of Antiepileptic Drugs throughout History: From Serendipity to Artificial Intelligence

Mariana Gaviria Carrillo, María Gabriela Corrales-Hernández, Sebastián Kurt Villarroel-Hagemann, Isabella Esther Mendoza-Rodelo, Leonardo Palacios Sanchez, Natalia Buitrago Ricaurte, Santiago Espinosa-Lugo, Carlos Alberto Calderon Ospina, Jesus Hernán Rodríguez Quintana

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

1 Cita (Scopus)


This article provides a comprehensive narrative review of the history of antiepileptic drugs (AEDs) and their development over time. Firstly, it explores the significant role of serendipity in the discovery of essential AEDs that continue to be used today, such as phenobarbital and valproic acid. Subsequently, it delves into the historical progression of crucial preclinical models employed in the development of novel AEDs, including the maximal electroshock stimulation test, pentylenetetrazol-induced test, kindling models, and other animal models. Moving forward, a concise overview of the clinical advancement of major AEDs is provided, highlighting the initial milestones and the subsequent refinement of this process in recent decades, in line with the emergence of evidence-based medicine and the implementation of increasingly rigorous controlled clinical trials. Lastly, the article explores the contributions of artificial intelligence, while also offering recommendations and discussing future perspectives for the development of new AEDs
Idioma originalInglés estadounidense
Páginas (desde-hasta)1-25
Número de páginas25
EstadoPublicada - may. 2023

Áreas temáticas de ASJC Scopus

  • Neurociencias General


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