Desenlaces clínicos en una cohorte colombiana de pacientes con síndrome de flujo vaginal tratadas con antimicóticos y antibióticos

Carlos Alberto Castro-Moreno, Guillermo Sánchez-Vanegas

Producción científica: Contribución a una revistaArtículo de Investigaciónrevisión exhaustiva

Resumen

OBJECTIVE: To know the real life clinical performance of the prescription of two drugs for the treatment of vaginal discharge syndrome (Fluconazole-Secnidazole and Terconazole-Clindamycin) and to compare the clinical outcomes. MATERIALS AND METHODS: An analytical cohort study was conducted. We included women older than 18 years with a diagnosis of vaginal discharge syndrome who were candidates to be treated with Fluconazole-Secnidazole or Terconazole-Clindamycin with 8 days (±3) of follow-up, in 12 cities of Colombia. This project was approved by a research with human being’s ethics committee. RESULTS: 176 patients were included, 153 (86.9%) completed the follow-up, their age ranged between 18 and 67 years. 134 (76.1%) started treatment with Fluconazole-Secnidazole and 42 (23.8%) Terconazole-Clindamycin. Symptoms improvement was compared (Enrollment vs. Control), finding for Fluconazole-Secnidazole and Terconazole-Clindamycin: discharge (p=0.0000), pruritus (p=0.002), irritation (p=0.0000), bad smell (p=0.001) and dyspareunia (p=0.4). CONCLUSIONS: The prescription of the combination Fluconazole-Secnidazole was more frequent. The adherence to treatment was 86%. The proportion of improvement in symptoms ranged between 15% and 40%, however, for the case of vaginal dis-charge it was greater than 70% (Fluconazole-Secnidazole: 115/121 and Terconazole-Clindamycin: 29/41).

Título traducido de la contribuciónClinical outcomes in a colombian cohort of patients with vaginal discharge syndrome treated with antifungals and antibiotics
Idioma originalEspañol
Páginas (desde-hasta)456-463
Número de páginas8
PublicaciónGinecologia y Obstetricia de Mexico
Volumen86
N.º7
DOI
EstadoPublicada - jul. 2018
Publicado de forma externa

Áreas temáticas de ASJC Scopus

  • Ginecología y obstetricia

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