Delayed lupus nephritis

D. C. Varela, G. Quintana, E. C. Somers, A. Rojas-Villarraga, G. Espinosa, M. E. Hincapie, W. J. McCune, R. Cervera, J. M. Anaya

Resultado de la investigación: Contribución a RevistaArtículo

15 Citas (Scopus)

Resumen

Objective: To describe and analyse the clinical and immunological characteristics of a large series of patients with delayed lupus nephritis (LN). Methods: A cross-sectional study was carried out. Patients with systemic lupus erythematosus (SLE) who developed renal involvement ≥5 years after the first manifestation (s) of the disease (delayed LN, n = 48) were compared with patients with SLE in whom LN developed within 5 years or less after SLE appeared (early-onset LN, n = 187). A control group, the no LN (NLN) group, comprised patients with longstanding SLE (duration of disease >10 years) who had never shown signs of renal involvement (n = 164). Results: The group with delayed LN was positively associated with Sjögren's syndrome, lung involvement and antiphospholipid syndrome as compared with early LN. However, its renal clinical expression and histopathological patterns were similar to those of early-onset LN. The frequency of anti-dsDNA, anti-Sm and anti-RNP antibodies was higher in patients with LN than in the NLN group, as was the frequency of low complement levels. Jaccoud's arthropathy was a protective factor for nephritis. Conclusions: Delayed LN is not uncommon in patients with SLE. The identified risk factors might aid in its diagnosis and enhance the ability to identify patients at risk for this complication of SLE.
Idioma originalEnglish (US)
Páginas (desde-hasta)1044-1046
Número de páginas3
PublicaciónAnnals of the Rheumatic Diseases
DOI
EstadoPublished - jul 1 2008

Huella dactilar

Lupus Nephritis
Systemic Lupus Erythematosus
Antibodies
Kidney
Antiphospholipid Syndrome
Nephritis
Joint Diseases
Sjogren's Syndrome
Anti-Idiotypic Antibodies
Cross-Sectional Studies
Lung
Control Groups

Citar esto

Varela, D. C., Quintana, G., Somers, E. C., Rojas-Villarraga, A., Espinosa, G., Hincapie, M. E., ... Anaya, J. M. (2008). Delayed lupus nephritis. Annals of the Rheumatic Diseases, 1044-1046. https://doi.org/10.1136/ard.2008.088740
Varela, D. C. ; Quintana, G. ; Somers, E. C. ; Rojas-Villarraga, A. ; Espinosa, G. ; Hincapie, M. E. ; McCune, W. J. ; Cervera, R. ; Anaya, J. M. / Delayed lupus nephritis. En: Annals of the Rheumatic Diseases. 2008 ; pp. 1044-1046.
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abstract = "Objective: To describe and analyse the clinical and immunological characteristics of a large series of patients with delayed lupus nephritis (LN). Methods: A cross-sectional study was carried out. Patients with systemic lupus erythematosus (SLE) who developed renal involvement ≥5 years after the first manifestation (s) of the disease (delayed LN, n = 48) were compared with patients with SLE in whom LN developed within 5 years or less after SLE appeared (early-onset LN, n = 187). A control group, the no LN (NLN) group, comprised patients with longstanding SLE (duration of disease >10 years) who had never shown signs of renal involvement (n = 164). Results: The group with delayed LN was positively associated with Sj{\"o}gren's syndrome, lung involvement and antiphospholipid syndrome as compared with early LN. However, its renal clinical expression and histopathological patterns were similar to those of early-onset LN. The frequency of anti-dsDNA, anti-Sm and anti-RNP antibodies was higher in patients with LN than in the NLN group, as was the frequency of low complement levels. Jaccoud's arthropathy was a protective factor for nephritis. Conclusions: Delayed LN is not uncommon in patients with SLE. The identified risk factors might aid in its diagnosis and enhance the ability to identify patients at risk for this complication of SLE.",
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Varela, DC, Quintana, G, Somers, EC, Rojas-Villarraga, A, Espinosa, G, Hincapie, ME, McCune, WJ, Cervera, R & Anaya, JM 2008, 'Delayed lupus nephritis', Annals of the Rheumatic Diseases, pp. 1044-1046. https://doi.org/10.1136/ard.2008.088740

Delayed lupus nephritis. / Varela, D. C.; Quintana, G.; Somers, E. C.; Rojas-Villarraga, A.; Espinosa, G.; Hincapie, M. E.; McCune, W. J.; Cervera, R.; Anaya, J. M.

En: Annals of the Rheumatic Diseases, 01.07.2008, p. 1044-1046.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Delayed lupus nephritis

AU - Varela, D. C.

AU - Quintana, G.

AU - Somers, E. C.

AU - Rojas-Villarraga, A.

AU - Espinosa, G.

AU - Hincapie, M. E.

AU - McCune, W. J.

AU - Cervera, R.

AU - Anaya, J. M.

PY - 2008/7/1

Y1 - 2008/7/1

N2 - Objective: To describe and analyse the clinical and immunological characteristics of a large series of patients with delayed lupus nephritis (LN). Methods: A cross-sectional study was carried out. Patients with systemic lupus erythematosus (SLE) who developed renal involvement ≥5 years after the first manifestation (s) of the disease (delayed LN, n = 48) were compared with patients with SLE in whom LN developed within 5 years or less after SLE appeared (early-onset LN, n = 187). A control group, the no LN (NLN) group, comprised patients with longstanding SLE (duration of disease >10 years) who had never shown signs of renal involvement (n = 164). Results: The group with delayed LN was positively associated with Sjögren's syndrome, lung involvement and antiphospholipid syndrome as compared with early LN. However, its renal clinical expression and histopathological patterns were similar to those of early-onset LN. The frequency of anti-dsDNA, anti-Sm and anti-RNP antibodies was higher in patients with LN than in the NLN group, as was the frequency of low complement levels. Jaccoud's arthropathy was a protective factor for nephritis. Conclusions: Delayed LN is not uncommon in patients with SLE. The identified risk factors might aid in its diagnosis and enhance the ability to identify patients at risk for this complication of SLE.

AB - Objective: To describe and analyse the clinical and immunological characteristics of a large series of patients with delayed lupus nephritis (LN). Methods: A cross-sectional study was carried out. Patients with systemic lupus erythematosus (SLE) who developed renal involvement ≥5 years after the first manifestation (s) of the disease (delayed LN, n = 48) were compared with patients with SLE in whom LN developed within 5 years or less after SLE appeared (early-onset LN, n = 187). A control group, the no LN (NLN) group, comprised patients with longstanding SLE (duration of disease >10 years) who had never shown signs of renal involvement (n = 164). Results: The group with delayed LN was positively associated with Sjögren's syndrome, lung involvement and antiphospholipid syndrome as compared with early LN. However, its renal clinical expression and histopathological patterns were similar to those of early-onset LN. The frequency of anti-dsDNA, anti-Sm and anti-RNP antibodies was higher in patients with LN than in the NLN group, as was the frequency of low complement levels. Jaccoud's arthropathy was a protective factor for nephritis. Conclusions: Delayed LN is not uncommon in patients with SLE. The identified risk factors might aid in its diagnosis and enhance the ability to identify patients at risk for this complication of SLE.

U2 - 10.1136/ard.2008.088740

DO - 10.1136/ard.2008.088740

M3 - Article

SP - 1044

EP - 1046

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

ER -

Varela DC, Quintana G, Somers EC, Rojas-Villarraga A, Espinosa G, Hincapie ME y otros. Delayed lupus nephritis. Annals of the Rheumatic Diseases. 2008 jul 1;1044-1046. https://doi.org/10.1136/ard.2008.088740