Deferral due to low hemoglobin and predictors of permanence in the blood donation system of repeat female blood donors

Adriana Urbina; Michel-Andrés García-Otálora; Dario Mendoza-Romero; Felix Rocha; Ayda Rodriguez; Fernando Palomino; Franz Weinauer

doi:10.1016/j.transci.2021.103340

Deferral due to low hemoglobin and predictors of permanence in the blood donation system of repeat female blood donors

Título traducido de la contribución: Diferimiento por baja hemoglobina y predictores de permanencia en el sistema de donación de sangre en donantes de sangre femeninas

Adriana Urbina
, Michel-Andrés García-Otálora
, Dario Mendoza-Romero
, Felix Rocha
, Ayda Rodriguez
, Fernando Palomino
, Franz Weinauer

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

6 Citas (Scopus)

190 Descargas (Pure)

Resumen

OBJETIVOS: Evaluar la tasa de aplazamiento por hemoglobina (Hb) baja en donantes de sangre femeninos repetidores e identificar los factores que afectan su permanencia en el sistema de donación de sangre.

MATERIALES Y MÉTODOS: Se incluyeron 8.368 donantes de sangre femeninos repetidores que donaron desde enero de 2012 hasta diciembre de 2018. Se utilizaron análisis bivariados y curvas de Kaplan-Meier para identificar las covariables posiblemente asociadas con el desarrollo de Hb baja, y se utilizó el modelado de riesgos proporcionales de Cox para ajustar por todos los factores de confusión.

RESULTADOS: La tasa global de aplazamiento por Hb baja fue del 2,4%. Según la Hb basal, la frecuencia de Hb baja fue del 0,7-4,1%, y fue mayor en los donantes de plaquetas (5,8-9,1%) que en los donantes de sangre total (1,9%). Los principales predictores fueron la Hb basal (en comparación con el primer cuartil; hazard ratio [HR] = 0,487 para el segundo cuartil; 0,234 para el tercero; y 0,095 para el cuarto); el cambio en la Hb (HR = 2,689 para un cambio >0. 49 g/dL, en comparación con cambios menores); el tipo de donación (en comparación con donantes de sangre total, HR = 2,317 para donantes de plaquetas); y el intervalo de donación (en comparación con intervalos de >12,5 meses; HR = 2,220 para 8,0-12,5 meses; HR = 5,658 para 5,4-8,0 meses; y HR = 9,452 para <5,4 meses).

CONCLUSIONES: En mujeres donantes de sangre a altitud moderada, la probabilidad de desarrollar Hb baja aumenta con una Hb basal de 13,5-14,0 g/dL, con un cambio en la Hb >0,49 g/dL, en donantes de plaquetas, y con intervalos de donación <12,5 meses. Estos cuatro factores predictivos pueden utilizarse conjuntamente para la identificación precoz de donantes con riesgo de desarrollar una Hb baja, a fin de instituir las medidas adecuadas.

Título traducido de la contribución	Diferimiento por baja hemoglobina y predictores de permanencia en el sistema de donación de sangre en donantes de sangre femeninas
Idioma original	Inglés estadounidense
Número de artículo	103340
Páginas (desde-hasta)	1-6
Número de páginas	6
Publicación	Transfusion and Apheresis Science
Volumen	61
N.º	3
DOI	https://doi.org/10.1016/j.transci.2021.103340
Estado	Publicada - jun 2022

ODS de las Naciones Unidas

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ODS 3: Salud y bienestar

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Salud pública, medioambiental y laboral

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@article{1a52a31894984f1e94b9f46ef72d8c66,

title = "Deferral due to low hemoglobin and predictors of permanence in the blood donation system of repeat female blood donors",

abstract = "OBJECTIVES: To evaluate the deferral rate due to low hemoglobin (Hb) in repeat female blood donors and identify the factors affecting their permanence in the blood donation system.MATERIALS AND METHODS: 8,368 repeat female blood donors who donated from January 2012 to December 2018 were included. Bivariate analysis and Kaplan-Meier curves were used to identify the covariates possibly associated with developing low Hb, and Cox proportional hazards modeling was used to adjust for all confounders.RESULTS: The global deferral rate due to low Hb was 2.4 \%. According to baseline Hb, the frequency of low Hb was 0.7-4.1 \%, and it was higher in platelet donors (5.8-9.1 \%) than in whole blood donors (1.9 \%). The main predictors were baseline Hb (compared to the first quartile; hazard ratio [HR] = 0.487 for the second quartile; 0.234 for the third; and 0.095 for the fourth); change in Hb (HR = 2.689 for a >0.49 g/dL change, compared to smaller changes); the type of donation (compared to whole blood donors, HR = 2.317 for platelet donors); and donation interval (compared to >12.5 month intervals; HR = 2.220 for 8.0-12.5 months; HR = 5.658 for 5.4-8.0 months; and HR = 9.452 for <5.4 months).CONCLUSIONS: In female blood donors at moderate altitude, the probability of developing low Hb increases with a baseline Hb of 13.5-14.0 g/dL, with a change in Hb >0.49 g/dL, in platelet donors, and with donation intervals <12.5 months. These four predictive factors can be used together for early identification of donors at risk of developing low Hb, to institute appropriate measures.",

author = "Adriana Urbina and Michel-Andr{\'e}s Garc{\'i}a-Ot{\'a}lora and Dario Mendoza-Romero and Felix Rocha and Ayda Rodriguez and Fernando Palomino and Franz Weinauer",

year = "2022",

month = jun,

doi = "10.1016/j.transci.2021.103340",

language = "English (US)",

volume = "61",

pages = "1--6",

journal = "Transfusion and Apheresis Science",

issn = "1473-0502",

publisher = "Elsevier Limited",

number = "3",

}

Deferral due to low hemoglobin and predictors of permanence in the blood donation system of repeat female blood donors. / Urbina, Adriana; García-Otálora, Michel-Andrés; Mendoza-Romero, Dario et al.
En: Transfusion and Apheresis Science, Vol. 61, N.º 3, 103340, 06.2022, p. 1-6.

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

TY - JOUR

T1 - Deferral due to low hemoglobin and predictors of permanence in the blood donation system of repeat female blood donors

AU - Urbina, Adriana

AU - García-Otálora, Michel-Andrés

AU - Mendoza-Romero, Dario

AU - Rocha, Felix

AU - Rodriguez, Ayda

AU - Palomino, Fernando

AU - Weinauer, Franz

PY - 2022/6

Y1 - 2022/6

N2 - OBJECTIVES: To evaluate the deferral rate due to low hemoglobin (Hb) in repeat female blood donors and identify the factors affecting their permanence in the blood donation system.MATERIALS AND METHODS: 8,368 repeat female blood donors who donated from January 2012 to December 2018 were included. Bivariate analysis and Kaplan-Meier curves were used to identify the covariates possibly associated with developing low Hb, and Cox proportional hazards modeling was used to adjust for all confounders.RESULTS: The global deferral rate due to low Hb was 2.4 %. According to baseline Hb, the frequency of low Hb was 0.7-4.1 %, and it was higher in platelet donors (5.8-9.1 %) than in whole blood donors (1.9 %). The main predictors were baseline Hb (compared to the first quartile; hazard ratio [HR] = 0.487 for the second quartile; 0.234 for the third; and 0.095 for the fourth); change in Hb (HR = 2.689 for a >0.49 g/dL change, compared to smaller changes); the type of donation (compared to whole blood donors, HR = 2.317 for platelet donors); and donation interval (compared to >12.5 month intervals; HR = 2.220 for 8.0-12.5 months; HR = 5.658 for 5.4-8.0 months; and HR = 9.452 for <5.4 months).CONCLUSIONS: In female blood donors at moderate altitude, the probability of developing low Hb increases with a baseline Hb of 13.5-14.0 g/dL, with a change in Hb >0.49 g/dL, in platelet donors, and with donation intervals <12.5 months. These four predictive factors can be used together for early identification of donors at risk of developing low Hb, to institute appropriate measures.

AB - OBJECTIVES: To evaluate the deferral rate due to low hemoglobin (Hb) in repeat female blood donors and identify the factors affecting their permanence in the blood donation system.MATERIALS AND METHODS: 8,368 repeat female blood donors who donated from January 2012 to December 2018 were included. Bivariate analysis and Kaplan-Meier curves were used to identify the covariates possibly associated with developing low Hb, and Cox proportional hazards modeling was used to adjust for all confounders.RESULTS: The global deferral rate due to low Hb was 2.4 %. According to baseline Hb, the frequency of low Hb was 0.7-4.1 %, and it was higher in platelet donors (5.8-9.1 %) than in whole blood donors (1.9 %). The main predictors were baseline Hb (compared to the first quartile; hazard ratio [HR] = 0.487 for the second quartile; 0.234 for the third; and 0.095 for the fourth); change in Hb (HR = 2.689 for a >0.49 g/dL change, compared to smaller changes); the type of donation (compared to whole blood donors, HR = 2.317 for platelet donors); and donation interval (compared to >12.5 month intervals; HR = 2.220 for 8.0-12.5 months; HR = 5.658 for 5.4-8.0 months; and HR = 9.452 for <5.4 months).CONCLUSIONS: In female blood donors at moderate altitude, the probability of developing low Hb increases with a baseline Hb of 13.5-14.0 g/dL, with a change in Hb >0.49 g/dL, in platelet donors, and with donation intervals <12.5 months. These four predictive factors can be used together for early identification of donors at risk of developing low Hb, to institute appropriate measures.

U2 - 10.1016/j.transci.2021.103340

DO - 10.1016/j.transci.2021.103340

M3 - Research Article

C2 - 34896008

SN - 1473-0502

VL - 61

SP - 1

EP - 6

JO - Transfusion and Apheresis Science

JF - Transfusion and Apheresis Science

IS - 3

M1 - 103340

ER -

Deferral due to low hemoglobin and predictors of permanence in the blood donation system of repeat female blood donors

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