Current understanding of the mixed pain concept: a brief narrative review

Rainer Freynhagen; Harold Arevalo Parada; Carlos Alberto Calderon-Ospina; Juythel Chen; Dessy Rakhmawati Emril; Freddy J Fernández-Villacorta; Hector Franco; Kok-Yuen Ho; Argelia Lara-Solares; Carina Ching-Fan Li; Alberto Mimenza Alvarado; Sasikaan Nimmaanrat; Maria Dolma Santos; Daniel Ciampi de Andrade

doi:10.1080/03007995.2018.1552042

Current understanding of the mixed pain concept: a brief narrative review

Título traducido de la contribución: Entendimiento actual del concepto de dolor mixto: una breve revisión narrativa

Rainer Freynhagen, Harold Arevalo Parada, Carlos Alberto Calderon-Ospina, Juythel Chen, Dessy Rakhmawati Emril, Freddy J Fernández-Villacorta, Hector Franco, Kok-Yuen Ho, Argelia Lara-Solares, Carina Ching-Fan Li, Alberto Mimenza Alvarado, Sasikaan Nimmaanrat, Maria Dolma Santos, Daniel Ciampi de Andrade

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

104 Citas (Scopus)

Resumen

A pesar de haber sido referenciado en la literatura por más de una década, el término "dolor mixto" nunca ha sido definido formalmente. La estricta clasificación binaria del dolor como puramente neuropático o nociceptivo dejó sin clasificar a una buena proporción de pacientes; incluso la reciente adopción del "dolor nociplástico" en la terminología de la IASP excluye a los pacientes que presentan clínicamente una superposición sustancial de síntomas nociceptivos y neuropáticos. Para estos pacientes, el término "dolor mixto" es cada vez más reconocido y aceptado por los clínicos. Por lo tanto, un grupo independiente de clínicos multidisciplinarios internacionales convocó una serie de discusiones informales para consolidar el conocimiento y articular todo lo que se conoce (o, más precisamente, se cree que se sabe) y todo lo que no se sabe acerca del dolor mixto. Para informar las discusiones del grupo, se realizó una búsqueda en Medline para el término médico "dolor mixto" a través de PubMed. La estrategia de búsqueda abarcó artículos de ensayos clínicos y revisiones desde enero de 1990 hasta el presente. Se seleccionaron y revisaron artículos de relevancia clínica. Este documento resume el consenso del grupo sobre varios aspectos clave del concepto de dolor mixto, que sirve como base para futuros intentos de generar una definición mecanística y / o clínica de dolor mixto. Una definición tendría implicaciones importantes para el desarrollo de recomendaciones o pautas para el diagnóstico y el tratamiento del dolor mixto.

Título traducido de la contribución	Entendimiento actual del concepto de dolor mixto: una breve revisión narrativa
Idioma original	Inglés estadounidense
Páginas (desde-hasta)	1-8
Número de páginas	8
Publicación	Current Medical Research and Opinion
Volumen	35
N.º	6
DOI	https://doi.org/10.1080/03007995.2018.1552042
Estado	Publicada - ene. 3 2019

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Freynhagen, R., Parada, H. A., Calderon-Ospina, C. A., Chen, J., Rakhmawati Emril, D., Fernández-Villacorta, F. J., Franco, H., Ho, K.-Y., Lara-Solares, A., Li, C. C.-F., Mimenza Alvarado, A., Nimmaanrat, S., Dolma Santos, M., & Ciampi de Andrade, D. (2019). Current understanding of the mixed pain concept: a brief narrative review. Current Medical Research and Opinion, 35(6), 1-8. https://doi.org/10.1080/03007995.2018.1552042

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title = "Current understanding of the mixed pain concept: a brief narrative review",

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year = "2019",

month = jan,

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doi = "10.1080/03007995.2018.1552042",

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Freynhagen, R, Parada, HA, Calderon-Ospina, CA, Chen, J, Rakhmawati Emril, D, Fernández-Villacorta, FJ, Franco, H, Ho, K-Y, Lara-Solares, A, Li, CC-F, Mimenza Alvarado, A, Nimmaanrat, S, Dolma Santos, M & Ciampi de Andrade, D 2019, 'Current understanding of the mixed pain concept: a brief narrative review', Current Medical Research and Opinion, vol. 35, n.º 6, pp. 1-8. https://doi.org/10.1080/03007995.2018.1552042

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T1 - Current understanding of the mixed pain concept: a brief narrative review

AU - Freynhagen, Rainer

AU - Parada, Harold Arevalo

AU - Calderon-Ospina, Carlos Alberto

AU - Chen, Juythel

AU - Rakhmawati Emril, Dessy

AU - Fernández-Villacorta, Freddy J

AU - Franco, Hector

AU - Ho, Kok-Yuen

AU - Lara-Solares, Argelia

AU - Li, Carina Ching-Fan

AU - Mimenza Alvarado, Alberto

AU - Nimmaanrat, Sasikaan

AU - Dolma Santos, Maria

AU - Ciampi de Andrade, Daniel

PY - 2019/1/3

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N2 - Despite having been referenced in the literature for over a decade, the term "mixed pain" has never been formally defined. The strict binary classification of pain as being either purely neuropathic or nociceptive once left a good proportion of patients unclassified; even the recent adoption of "nociplastic pain" in the IASP Terminology leaves out patients who present clinically with a substantial overlap of nociceptive and neuropathic symptoms. For these patients, the term "mixed pain" is increasingly recognized and accepted by clinicians. Thus, an independent group of international multidisciplinary clinicians convened a series of informal discussions to consolidate knowledge and articulate all that is known (or, more accurately, thought to be known) and all that is not known about mixed pain. To inform the group's discussions, a Medline search for the Medical Subject Heading "mixed pain" was performed via PubMed. The search strategy encompassed clinical trial articles and reviews from January 1990 to the present. Clinically relevant articles were selected and reviewed. This paper summarizes the group's consensus on several key aspects of the mixed pain concept, to serve as a foundation for future attempts at generating a mechanistic and/or clinical definition of mixed pain. A definition would have important implications for the development of recommendations or guidelines for diagnosis and treatment of mixed pain.

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UR - https://www.tandfonline.com/doi/full/10.1080/03007995.2018.1552042

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DO - 10.1080/03007995.2018.1552042

M3 - Article

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SN - 0300-7995

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EP - 8

JO - Current Medical Research and Opinion

JF - Current Medical Research and Opinion

IS - 6

ER -

Current understanding of the mixed pain concept: a brief narrative review

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