Contribution of mitochondria to pain in diabetic neuropathy

Natalia Hernández-Beltrán, Carlos B. Moreno, ángela María Gutiérrez-álvarez

Resultado de la investigación: Contribución a RevistaRevisión corta

8 Citas (Scopus)

Resumen

Diabetes is a metabolic disease affecting approximately 300 million people worldwide. Neuropathy is one of its frequent complications, and may affect sensory, motor, and autonomic nerves. Its pathophysiology has not fully been elucidated. Several hypotheses have been proposed, and mitochondria have been suggested to play a significant role. This article reviews the mechanisms involved in mitochondrial dysfunction and development of diabetic neuropathy, consisting mainly of oxidative and inflammatory stress, changes in intracellular calcium regulation, apoptotic processes, and changes in mitochondrial structure and function that may lead to development of diabetic neuropathy. © 2011 SEEN.
Idioma originalEnglish (US)
Páginas (desde-hasta)25-32
Número de páginas8
PublicaciónEndocrinologia y Nutricion
DOI
EstadoPublished - ene 1 2013

Huella dactilar

Diabetic Neuropathies
Mitochondria
Autonomic Pathways
Pain
Metabolic Diseases
Oxidative Stress
Calcium

Citar esto

Hernández-Beltrán, N., Moreno, C. B., & Gutiérrez-álvarez, Á. M. (2013). Contribution of mitochondria to pain in diabetic neuropathy. Endocrinologia y Nutricion, 25-32. https://doi.org/10.1016/j.endonu.2012.03.005
Hernández-Beltrán, Natalia ; Moreno, Carlos B. ; Gutiérrez-álvarez, ángela María. / Contribution of mitochondria to pain in diabetic neuropathy. En: Endocrinologia y Nutricion. 2013 ; pp. 25-32.
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Contribution of mitochondria to pain in diabetic neuropathy. / Hernández-Beltrán, Natalia; Moreno, Carlos B.; Gutiérrez-álvarez, ángela María.

En: Endocrinologia y Nutricion, 01.01.2013, p. 25-32.

Resultado de la investigación: Contribución a RevistaRevisión corta

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T1 - Contribution of mitochondria to pain in diabetic neuropathy

AU - Hernández-Beltrán, Natalia

AU - Moreno, Carlos B.

AU - Gutiérrez-álvarez, ángela María

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Diabetes is a metabolic disease affecting approximately 300 million people worldwide. Neuropathy is one of its frequent complications, and may affect sensory, motor, and autonomic nerves. Its pathophysiology has not fully been elucidated. Several hypotheses have been proposed, and mitochondria have been suggested to play a significant role. This article reviews the mechanisms involved in mitochondrial dysfunction and development of diabetic neuropathy, consisting mainly of oxidative and inflammatory stress, changes in intracellular calcium regulation, apoptotic processes, and changes in mitochondrial structure and function that may lead to development of diabetic neuropathy. © 2011 SEEN.

AB - Diabetes is a metabolic disease affecting approximately 300 million people worldwide. Neuropathy is one of its frequent complications, and may affect sensory, motor, and autonomic nerves. Its pathophysiology has not fully been elucidated. Several hypotheses have been proposed, and mitochondria have been suggested to play a significant role. This article reviews the mechanisms involved in mitochondrial dysfunction and development of diabetic neuropathy, consisting mainly of oxidative and inflammatory stress, changes in intracellular calcium regulation, apoptotic processes, and changes in mitochondrial structure and function that may lead to development of diabetic neuropathy. © 2011 SEEN.

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DO - 10.1016/j.endonu.2012.03.005

M3 - Short survey

SP - 25

EP - 32

JO - Endocrinologia, Diabetes y Nutricion

JF - Endocrinologia, Diabetes y Nutricion

SN - 2530-0164

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