Confirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: Evidence of a general susceptibility locus

Amit K. Maiti, Xana Kim-Howard, Parvathi Viswanathan, Laura Guillén, Adriana Rojas-Villarraga, Harshal Deshmukh, Haner Direskeneli, Güher Saruhan-Direskeneli, Carlos Cañas, Gabriel J. Tobón, Amr H. Sawalha, Alejandra C. Cherñavsky, Juan Manuel Anaya, Swapan K. Nath

Resultado de la investigación: Contribución a RevistaArtículo

58 Citas (Scopus)

Resumen

Objective. Autoimmune diseases often have susceptibility genes in common, indicating similar molecular mechanisms. Increasing evidence suggests that rs6822844 at the IL2-IL21 region is strongly associated with multiple autoimmune diseases in individuals of European descent. This study was undertaken to attempt to replicate the association between rs6822844 and 6 different immune-mediated diseases in non-European populations, and to perform disease-specific and overall meta-analyses using data from previously published studies. Methods. We evaluated case-control associations between rs6822844 and celiac disease (CD) in subjects from Argentina; rheumatoid arthritis (RA), type 1 diabetes mellitus (DM), primary Sjögren's syndrome (SS), and systemic lupus erythematosus (SLE) in subjects from Colombia; and Behçet's disease (BD) in subjects from Turkey. Allele and gene distributions were compared between cases and controls. Meta-analyses were performed using data from the present study and previous studies. Results. We detected significant associations of rs6822844 with SLE (P = 0.008), type 1 DM(P = 0.014), RA (P = 0.019), and primary SS (P = 0.033) but not with BD (P = 0.34) or CD (P = 0.98). We identified little evidence of population differentiation (FST = 0.01) within cases and controls from Argentina and Colombia, suggesting that association was not influenced by population substructure. Disease-specific meta-analysis indicated significant association for RA (Pmeta = 3.61 × 10-6), inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis) (Pmeta = 3.48 × 10-12), type 1 DM (Pmeta = 5.33 × 10-5), and CD (Pmeta = 5.30 × 10-3). Overall meta-analysis across all autoimmune diseases reinforced association with rs6822844 (23 data sets; Pmeta = 2.61 × 10-25, odds ratio 0.73 [95% confidence interval 0.69-0.78]). Conclusion. Our results indicate that there is an association between rs6822844 and multiple autoimmune diseases in non-European populations. Metaanalysis results strongly reinforce this robust association across multiple autoimmune diseases in both European-derived and non-European populations. © 2010, American College of Rheumatology.
Idioma originalEnglish (US)
Páginas (desde-hasta)323-329
Número de páginas7
PublicaciónArthritis and Rheumatism
DOI
EstadoPublished - feb 1 2010

Huella dactilar

Autoimmune Diseases
Interleukin-2
Meta-Analysis
Celiac Disease
Type 1 Diabetes Mellitus
Rheumatoid Arthritis
Colombia
Behcet Syndrome
Population
Sjogren's Syndrome
Argentina
Systemic Lupus Erythematosus
Immune System Diseases
Turkey
Ulcerative Colitis
Crohn Disease
Genes
Alleles
Odds Ratio
interleukin-21

Citar esto

Maiti, Amit K. ; Kim-Howard, Xana ; Viswanathan, Parvathi ; Guillén, Laura ; Rojas-Villarraga, Adriana ; Deshmukh, Harshal ; Direskeneli, Haner ; Saruhan-Direskeneli, Güher ; Cañas, Carlos ; Tobón, Gabriel J. ; Sawalha, Amr H. ; Cherñavsky, Alejandra C. ; Anaya, Juan Manuel ; Nath, Swapan K. / Confirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: Evidence of a general susceptibility locus. En: Arthritis and Rheumatism. 2010 ; pp. 323-329.
@article{0eaa1cab08fc46608d4fd9becb178b7a,
title = "Confirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: Evidence of a general susceptibility locus",
abstract = "Objective. Autoimmune diseases often have susceptibility genes in common, indicating similar molecular mechanisms. Increasing evidence suggests that rs6822844 at the IL2-IL21 region is strongly associated with multiple autoimmune diseases in individuals of European descent. This study was undertaken to attempt to replicate the association between rs6822844 and 6 different immune-mediated diseases in non-European populations, and to perform disease-specific and overall meta-analyses using data from previously published studies. Methods. We evaluated case-control associations between rs6822844 and celiac disease (CD) in subjects from Argentina; rheumatoid arthritis (RA), type 1 diabetes mellitus (DM), primary Sj{\"o}gren's syndrome (SS), and systemic lupus erythematosus (SLE) in subjects from Colombia; and Beh{\cc}et's disease (BD) in subjects from Turkey. Allele and gene distributions were compared between cases and controls. Meta-analyses were performed using data from the present study and previous studies. Results. We detected significant associations of rs6822844 with SLE (P = 0.008), type 1 DM(P = 0.014), RA (P = 0.019), and primary SS (P = 0.033) but not with BD (P = 0.34) or CD (P = 0.98). We identified little evidence of population differentiation (FST = 0.01) within cases and controls from Argentina and Colombia, suggesting that association was not influenced by population substructure. Disease-specific meta-analysis indicated significant association for RA (Pmeta = 3.61 × 10-6), inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis) (Pmeta = 3.48 × 10-12), type 1 DM (Pmeta = 5.33 × 10-5), and CD (Pmeta = 5.30 × 10-3). Overall meta-analysis across all autoimmune diseases reinforced association with rs6822844 (23 data sets; Pmeta = 2.61 × 10-25, odds ratio 0.73 [95{\%} confidence interval 0.69-0.78]). Conclusion. Our results indicate that there is an association between rs6822844 and multiple autoimmune diseases in non-European populations. Metaanalysis results strongly reinforce this robust association across multiple autoimmune diseases in both European-derived and non-European populations. {\circledC} 2010, American College of Rheumatology.",
author = "Maiti, {Amit K.} and Xana Kim-Howard and Parvathi Viswanathan and Laura Guill{\'e}n and Adriana Rojas-Villarraga and Harshal Deshmukh and Haner Direskeneli and G{\"u}her Saruhan-Direskeneli and Carlos Ca{\~n}as and Tob{\'o}n, {Gabriel J.} and Sawalha, {Amr H.} and Cher{\~n}avsky, {Alejandra C.} and Anaya, {Juan Manuel} and Nath, {Swapan K.}",
year = "2010",
month = "2",
day = "1",
doi = "10.1002/art.27222",
language = "English (US)",
pages = "323--329",
journal = "Arthritis and Rheumatology",
issn = "2326-5191",
publisher = "John Wiley and Sons Ltd",

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Maiti, AK, Kim-Howard, X, Viswanathan, P, Guillén, L, Rojas-Villarraga, A, Deshmukh, H, Direskeneli, H, Saruhan-Direskeneli, G, Cañas, C, Tobón, GJ, Sawalha, AH, Cherñavsky, AC, Anaya, JM & Nath, SK 2010, 'Confirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: Evidence of a general susceptibility locus', Arthritis and Rheumatism, pp. 323-329. https://doi.org/10.1002/art.27222

Confirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: Evidence of a general susceptibility locus. / Maiti, Amit K.; Kim-Howard, Xana; Viswanathan, Parvathi; Guillén, Laura; Rojas-Villarraga, Adriana; Deshmukh, Harshal; Direskeneli, Haner; Saruhan-Direskeneli, Güher; Cañas, Carlos; Tobón, Gabriel J.; Sawalha, Amr H.; Cherñavsky, Alejandra C.; Anaya, Juan Manuel; Nath, Swapan K.

En: Arthritis and Rheumatism, 01.02.2010, p. 323-329.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Confirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: Evidence of a general susceptibility locus

AU - Maiti, Amit K.

AU - Kim-Howard, Xana

AU - Viswanathan, Parvathi

AU - Guillén, Laura

AU - Rojas-Villarraga, Adriana

AU - Deshmukh, Harshal

AU - Direskeneli, Haner

AU - Saruhan-Direskeneli, Güher

AU - Cañas, Carlos

AU - Tobón, Gabriel J.

AU - Sawalha, Amr H.

AU - Cherñavsky, Alejandra C.

AU - Anaya, Juan Manuel

AU - Nath, Swapan K.

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Objective. Autoimmune diseases often have susceptibility genes in common, indicating similar molecular mechanisms. Increasing evidence suggests that rs6822844 at the IL2-IL21 region is strongly associated with multiple autoimmune diseases in individuals of European descent. This study was undertaken to attempt to replicate the association between rs6822844 and 6 different immune-mediated diseases in non-European populations, and to perform disease-specific and overall meta-analyses using data from previously published studies. Methods. We evaluated case-control associations between rs6822844 and celiac disease (CD) in subjects from Argentina; rheumatoid arthritis (RA), type 1 diabetes mellitus (DM), primary Sjögren's syndrome (SS), and systemic lupus erythematosus (SLE) in subjects from Colombia; and Behçet's disease (BD) in subjects from Turkey. Allele and gene distributions were compared between cases and controls. Meta-analyses were performed using data from the present study and previous studies. Results. We detected significant associations of rs6822844 with SLE (P = 0.008), type 1 DM(P = 0.014), RA (P = 0.019), and primary SS (P = 0.033) but not with BD (P = 0.34) or CD (P = 0.98). We identified little evidence of population differentiation (FST = 0.01) within cases and controls from Argentina and Colombia, suggesting that association was not influenced by population substructure. Disease-specific meta-analysis indicated significant association for RA (Pmeta = 3.61 × 10-6), inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis) (Pmeta = 3.48 × 10-12), type 1 DM (Pmeta = 5.33 × 10-5), and CD (Pmeta = 5.30 × 10-3). Overall meta-analysis across all autoimmune diseases reinforced association with rs6822844 (23 data sets; Pmeta = 2.61 × 10-25, odds ratio 0.73 [95% confidence interval 0.69-0.78]). Conclusion. Our results indicate that there is an association between rs6822844 and multiple autoimmune diseases in non-European populations. Metaanalysis results strongly reinforce this robust association across multiple autoimmune diseases in both European-derived and non-European populations. © 2010, American College of Rheumatology.

AB - Objective. Autoimmune diseases often have susceptibility genes in common, indicating similar molecular mechanisms. Increasing evidence suggests that rs6822844 at the IL2-IL21 region is strongly associated with multiple autoimmune diseases in individuals of European descent. This study was undertaken to attempt to replicate the association between rs6822844 and 6 different immune-mediated diseases in non-European populations, and to perform disease-specific and overall meta-analyses using data from previously published studies. Methods. We evaluated case-control associations between rs6822844 and celiac disease (CD) in subjects from Argentina; rheumatoid arthritis (RA), type 1 diabetes mellitus (DM), primary Sjögren's syndrome (SS), and systemic lupus erythematosus (SLE) in subjects from Colombia; and Behçet's disease (BD) in subjects from Turkey. Allele and gene distributions were compared between cases and controls. Meta-analyses were performed using data from the present study and previous studies. Results. We detected significant associations of rs6822844 with SLE (P = 0.008), type 1 DM(P = 0.014), RA (P = 0.019), and primary SS (P = 0.033) but not with BD (P = 0.34) or CD (P = 0.98). We identified little evidence of population differentiation (FST = 0.01) within cases and controls from Argentina and Colombia, suggesting that association was not influenced by population substructure. Disease-specific meta-analysis indicated significant association for RA (Pmeta = 3.61 × 10-6), inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis) (Pmeta = 3.48 × 10-12), type 1 DM (Pmeta = 5.33 × 10-5), and CD (Pmeta = 5.30 × 10-3). Overall meta-analysis across all autoimmune diseases reinforced association with rs6822844 (23 data sets; Pmeta = 2.61 × 10-25, odds ratio 0.73 [95% confidence interval 0.69-0.78]). Conclusion. Our results indicate that there is an association between rs6822844 and multiple autoimmune diseases in non-European populations. Metaanalysis results strongly reinforce this robust association across multiple autoimmune diseases in both European-derived and non-European populations. © 2010, American College of Rheumatology.

U2 - 10.1002/art.27222

DO - 10.1002/art.27222

M3 - Article

SP - 323

EP - 329

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

SN - 2326-5191

ER -