Comparison of the American-European Consensus Group Sjögren's syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised sicca cohort

Astrid Rasmussen, John A. Ice, He Li, Kiely Grundahl, Jennifer A. Kelly, Lida Radfar, Donald U. Stone, Kimberly S. Hefner, Juan Manuel Anaya, Michael Rohrer, Rajaram Gopalakrishnan, Glen D. Houston, David M. Lewis, James Chodosh, John B. Harley, Pamela Hughes, Jacen S. Maier-Moore, Courtney G. Montgomery, Nelson L. Rhodus, A. Darise FarrisBarbara M. Segal, Roland Jonsson, Christopher J. Lessard, R. Hal Scofield, Kathy L. Moser Sivils

Resultado de la investigación: Contribución a RevistaRevisión Literaria

95 Citas (Scopus)

Resumen

Objective To compare the performance of the American-European Consensus Group (AECG) and the newly proposed American College of Rheumatology (ACR) classification criteria for Sjögren's Syndrome (SS) in a well-characterised sicca cohort, given ongoing efforts to resolve discrepancies and weaknesses in the systems. Methods In a multidisciplinary clinic for the evaluation of sicca, we assessed features of salivary and lacrimal gland dysfunction and autoimmunity as defined by tests of both AECG and ACR criteria in 646 participants. Global gene expression profiles were compared in a subset of 180 participants. Results Application of the AECG and ACR criteria resulted in classification of 279 and 268 participants with SS, respectively. Both criteria were met by 244 participants (81%). In 26 of the 35 AECG+/ACR participants, the minor salivary gland biopsy focal score was ≥1 (74%), while nine had positive anti-Ro/La (26%). There were 24 AECG-/ACR+ who met ACR criteria mainly due to differences in the scoring of corneal staining. All patients with SS, regardless of classification, had similar gene expression profiles, which were distinct from the healthy controls. Conclusions The two sets of classification criteria yield concordant results in the majority of cases and gene expression profiling suggests that patients meeting either set of criteria are more similar to other SS participants than to healthy controls. Thus, there is no clear evidence for increased value of the new ACR criteria over the old AECG criteria from the clinical or biological perspective. It is our contention, supported by this report, that improvements in diagnostic acumen will require a more fundamental understanding of the pathogenic mechanisms than is at present available.
Idioma originalEnglish (US)
Páginas (desde-hasta)31-38
Número de páginas8
PublicaciónAnnals of the Rheumatic Diseases
DOI
EstadoPublished - ene 1 2014

Huella dactilar

Sjogren's Syndrome
Rheumatology
Gene expression
Transcriptome
Minor Salivary Glands
Lacrimal Apparatus
Biopsy
Gene Expression Profiling
Salivary Glands
Autoimmunity
Healthy Volunteers
Staining and Labeling

Citar esto

Rasmussen, Astrid ; Ice, John A. ; Li, He ; Grundahl, Kiely ; Kelly, Jennifer A. ; Radfar, Lida ; Stone, Donald U. ; Hefner, Kimberly S. ; Anaya, Juan Manuel ; Rohrer, Michael ; Gopalakrishnan, Rajaram ; Houston, Glen D. ; Lewis, David M. ; Chodosh, James ; Harley, John B. ; Hughes, Pamela ; Maier-Moore, Jacen S. ; Montgomery, Courtney G. ; Rhodus, Nelson L. ; Farris, A. Darise ; Segal, Barbara M. ; Jonsson, Roland ; Lessard, Christopher J. ; Scofield, R. Hal ; Moser Sivils, Kathy L. / Comparison of the American-European Consensus Group Sjögren's syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised sicca cohort. En: Annals of the Rheumatic Diseases. 2014 ; pp. 31-38.
@article{d9989a282e784f2aaad7e2e92661b8d0,
title = "Comparison of the American-European Consensus Group Sj{\"o}gren's syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised sicca cohort",
abstract = "Objective To compare the performance of the American-European Consensus Group (AECG) and the newly proposed American College of Rheumatology (ACR) classification criteria for Sj{\"o}gren's Syndrome (SS) in a well-characterised sicca cohort, given ongoing efforts to resolve discrepancies and weaknesses in the systems. Methods In a multidisciplinary clinic for the evaluation of sicca, we assessed features of salivary and lacrimal gland dysfunction and autoimmunity as defined by tests of both AECG and ACR criteria in 646 participants. Global gene expression profiles were compared in a subset of 180 participants. Results Application of the AECG and ACR criteria resulted in classification of 279 and 268 participants with SS, respectively. Both criteria were met by 244 participants (81{\%}). In 26 of the 35 AECG+/ACR participants, the minor salivary gland biopsy focal score was ≥1 (74{\%}), while nine had positive anti-Ro/La (26{\%}). There were 24 AECG-/ACR+ who met ACR criteria mainly due to differences in the scoring of corneal staining. All patients with SS, regardless of classification, had similar gene expression profiles, which were distinct from the healthy controls. Conclusions The two sets of classification criteria yield concordant results in the majority of cases and gene expression profiling suggests that patients meeting either set of criteria are more similar to other SS participants than to healthy controls. Thus, there is no clear evidence for increased value of the new ACR criteria over the old AECG criteria from the clinical or biological perspective. It is our contention, supported by this report, that improvements in diagnostic acumen will require a more fundamental understanding of the pathogenic mechanisms than is at present available.",
author = "Astrid Rasmussen and Ice, {John A.} and He Li and Kiely Grundahl and Kelly, {Jennifer A.} and Lida Radfar and Stone, {Donald U.} and Hefner, {Kimberly S.} and Anaya, {Juan Manuel} and Michael Rohrer and Rajaram Gopalakrishnan and Houston, {Glen D.} and Lewis, {David M.} and James Chodosh and Harley, {John B.} and Pamela Hughes and Maier-Moore, {Jacen S.} and Montgomery, {Courtney G.} and Rhodus, {Nelson L.} and Farris, {A. Darise} and Segal, {Barbara M.} and Roland Jonsson and Lessard, {Christopher J.} and Scofield, {R. Hal} and {Moser Sivils}, {Kathy L.}",
year = "2014",
month = "1",
day = "1",
doi = "10.1136/annrheumdis-2013-203845",
language = "English (US)",
pages = "31--38",
journal = "Annals of the Rheumatic Diseases",
issn = "0003-4967",
publisher = "BMJ Publishing Group",

}

Rasmussen, A, Ice, JA, Li, H, Grundahl, K, Kelly, JA, Radfar, L, Stone, DU, Hefner, KS, Anaya, JM, Rohrer, M, Gopalakrishnan, R, Houston, GD, Lewis, DM, Chodosh, J, Harley, JB, Hughes, P, Maier-Moore, JS, Montgomery, CG, Rhodus, NL, Farris, AD, Segal, BM, Jonsson, R, Lessard, CJ, Scofield, RH & Moser Sivils, KL 2014, 'Comparison of the American-European Consensus Group Sjögren's syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised sicca cohort', Annals of the Rheumatic Diseases, pp. 31-38. https://doi.org/10.1136/annrheumdis-2013-203845

Comparison of the American-European Consensus Group Sjögren's syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised sicca cohort. / Rasmussen, Astrid; Ice, John A.; Li, He; Grundahl, Kiely; Kelly, Jennifer A.; Radfar, Lida; Stone, Donald U.; Hefner, Kimberly S.; Anaya, Juan Manuel; Rohrer, Michael; Gopalakrishnan, Rajaram; Houston, Glen D.; Lewis, David M.; Chodosh, James; Harley, John B.; Hughes, Pamela; Maier-Moore, Jacen S.; Montgomery, Courtney G.; Rhodus, Nelson L.; Farris, A. Darise; Segal, Barbara M.; Jonsson, Roland; Lessard, Christopher J.; Scofield, R. Hal; Moser Sivils, Kathy L.

En: Annals of the Rheumatic Diseases, 01.01.2014, p. 31-38.

Resultado de la investigación: Contribución a RevistaRevisión Literaria

TY - JOUR

T1 - Comparison of the American-European Consensus Group Sjögren's syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised sicca cohort

AU - Rasmussen, Astrid

AU - Ice, John A.

AU - Li, He

AU - Grundahl, Kiely

AU - Kelly, Jennifer A.

AU - Radfar, Lida

AU - Stone, Donald U.

AU - Hefner, Kimberly S.

AU - Anaya, Juan Manuel

AU - Rohrer, Michael

AU - Gopalakrishnan, Rajaram

AU - Houston, Glen D.

AU - Lewis, David M.

AU - Chodosh, James

AU - Harley, John B.

AU - Hughes, Pamela

AU - Maier-Moore, Jacen S.

AU - Montgomery, Courtney G.

AU - Rhodus, Nelson L.

AU - Farris, A. Darise

AU - Segal, Barbara M.

AU - Jonsson, Roland

AU - Lessard, Christopher J.

AU - Scofield, R. Hal

AU - Moser Sivils, Kathy L.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objective To compare the performance of the American-European Consensus Group (AECG) and the newly proposed American College of Rheumatology (ACR) classification criteria for Sjögren's Syndrome (SS) in a well-characterised sicca cohort, given ongoing efforts to resolve discrepancies and weaknesses in the systems. Methods In a multidisciplinary clinic for the evaluation of sicca, we assessed features of salivary and lacrimal gland dysfunction and autoimmunity as defined by tests of both AECG and ACR criteria in 646 participants. Global gene expression profiles were compared in a subset of 180 participants. Results Application of the AECG and ACR criteria resulted in classification of 279 and 268 participants with SS, respectively. Both criteria were met by 244 participants (81%). In 26 of the 35 AECG+/ACR participants, the minor salivary gland biopsy focal score was ≥1 (74%), while nine had positive anti-Ro/La (26%). There were 24 AECG-/ACR+ who met ACR criteria mainly due to differences in the scoring of corneal staining. All patients with SS, regardless of classification, had similar gene expression profiles, which were distinct from the healthy controls. Conclusions The two sets of classification criteria yield concordant results in the majority of cases and gene expression profiling suggests that patients meeting either set of criteria are more similar to other SS participants than to healthy controls. Thus, there is no clear evidence for increased value of the new ACR criteria over the old AECG criteria from the clinical or biological perspective. It is our contention, supported by this report, that improvements in diagnostic acumen will require a more fundamental understanding of the pathogenic mechanisms than is at present available.

AB - Objective To compare the performance of the American-European Consensus Group (AECG) and the newly proposed American College of Rheumatology (ACR) classification criteria for Sjögren's Syndrome (SS) in a well-characterised sicca cohort, given ongoing efforts to resolve discrepancies and weaknesses in the systems. Methods In a multidisciplinary clinic for the evaluation of sicca, we assessed features of salivary and lacrimal gland dysfunction and autoimmunity as defined by tests of both AECG and ACR criteria in 646 participants. Global gene expression profiles were compared in a subset of 180 participants. Results Application of the AECG and ACR criteria resulted in classification of 279 and 268 participants with SS, respectively. Both criteria were met by 244 participants (81%). In 26 of the 35 AECG+/ACR participants, the minor salivary gland biopsy focal score was ≥1 (74%), while nine had positive anti-Ro/La (26%). There were 24 AECG-/ACR+ who met ACR criteria mainly due to differences in the scoring of corneal staining. All patients with SS, regardless of classification, had similar gene expression profiles, which were distinct from the healthy controls. Conclusions The two sets of classification criteria yield concordant results in the majority of cases and gene expression profiling suggests that patients meeting either set of criteria are more similar to other SS participants than to healthy controls. Thus, there is no clear evidence for increased value of the new ACR criteria over the old AECG criteria from the clinical or biological perspective. It is our contention, supported by this report, that improvements in diagnostic acumen will require a more fundamental understanding of the pathogenic mechanisms than is at present available.

U2 - 10.1136/annrheumdis-2013-203845

DO - 10.1136/annrheumdis-2013-203845

M3 - Literature review

C2 - 23968620

SP - 31

EP - 38

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

ER -