Cloning, expression, and characterisation of a Plasmodium vivax MSP7 family merozoite surface protein

Alvaro Mongui; Oscar Perez-Leal; Sara C. Soto; Jimena Cortes; Manuel A. Patarroyo

doi:10.1016/j.bbrc.2006.10.082

Cloning, expression, and characterisation of a Plasmodium vivax MSP7 family merozoite surface protein

Título traducido de la contribución: Clonación, expresión y caracterización de una proteína de superficie del merozoito de la familia MSP7 de Plasmodium vivax

Alvaro Mongui
, Oscar Perez-Leal
, Sara C. Soto
, Jimena Cortes
, Manuel A. Patarroyo

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

22 Citas (Scopus)

Resumen

Plasmodium vivax sigue siendo la especie de parásito Plasmodium más extendida en todo el mundo, y produce unos 75 millones de casos de paludismo, principalmente en Sudamérica y Asia. La identificación de nuevos antígenos implicados en la invasión de células diana y, por tanto, posibles candidatos a vacuna, es una prioridad. En este estudio se identificó una proteína perteneciente a la familia de la proteína de superficie del merozoito 7 de P. vivax (PvMSP7). Esta proteína (denominada PvMSP71) tiene 311 aminoácidos que muestran una región N-terminal que comparte una alta identidad con la MSP7 de P. falciparum, así como un patrón de escisión proteolítica similar. La expresión de esta proteína en estadios sanguíneos asexuales de P. vivax se reveló mediante técnicas inmunohistoquímicas y moleculares.

Título traducido de la contribución	Clonación, expresión y caracterización de una proteína de superficie del merozoito de la familia MSP7 de Plasmodium vivax
Idioma original	Inglés estadounidense
Páginas (desde-hasta)	639-644
Número de páginas	6
Publicación	Biochemical and Biophysical Research Communications
Volumen	351
N.º	3
DOI	https://doi.org/10.1016/j.bbrc.2006.10.082
Estado	Publicada - dic. 22 2006

ODS de las Naciones Unidas

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ODS 3: Salud y bienestar

Áreas temáticas de ASJC Scopus

Inmulogía y alergología

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title = "Cloning, expression, and characterisation of a Plasmodium vivax MSP7 family merozoite surface protein",

abstract = "Plasmodium vivax remains the most widespread Plasmodium parasite specie around the world, producing about 75 million malaria cases, mainly in South America and Asia. A vaccine against this disease is of urgent need, making the identification of new antigens involved in target cell invasion, and thus potential vaccine candidates, a priority. A protein belonging to the P. vivax merozoite surface protein 7 (PvMSP7) family was identified in this study. This protein (named PvMSP71) has 311 amino acids displaying an N-terminal region sharing high identity with P. falciparum MSP7, as well as a similar proteolytical cleavage pattern. This protein's expression in P. vivax asexual blood stages was revealed by immuno-histochemical and molecular techniques. {\textcopyright} 2006 Elsevier Inc. All rights reserved.",

author = "Alvaro Mongui and Oscar Perez-Leal and Soto, \{Sara C.\} and Jimena Cortes and Patarroyo, \{Manuel A.\}",

year = "2006",

month = dec,

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doi = "10.1016/j.bbrc.2006.10.082",

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TY - JOUR

T1 - Cloning, expression, and characterisation of a Plasmodium vivax MSP7 family merozoite surface protein

AU - Mongui, Alvaro

AU - Perez-Leal, Oscar

AU - Soto, Sara C.

AU - Cortes, Jimena

AU - Patarroyo, Manuel A.

PY - 2006/12/22

Y1 - 2006/12/22

N2 - Plasmodium vivax remains the most widespread Plasmodium parasite specie around the world, producing about 75 million malaria cases, mainly in South America and Asia. A vaccine against this disease is of urgent need, making the identification of new antigens involved in target cell invasion, and thus potential vaccine candidates, a priority. A protein belonging to the P. vivax merozoite surface protein 7 (PvMSP7) family was identified in this study. This protein (named PvMSP71) has 311 amino acids displaying an N-terminal region sharing high identity with P. falciparum MSP7, as well as a similar proteolytical cleavage pattern. This protein's expression in P. vivax asexual blood stages was revealed by immuno-histochemical and molecular techniques. © 2006 Elsevier Inc. All rights reserved.

AB - Plasmodium vivax remains the most widespread Plasmodium parasite specie around the world, producing about 75 million malaria cases, mainly in South America and Asia. A vaccine against this disease is of urgent need, making the identification of new antigens involved in target cell invasion, and thus potential vaccine candidates, a priority. A protein belonging to the P. vivax merozoite surface protein 7 (PvMSP7) family was identified in this study. This protein (named PvMSP71) has 311 amino acids displaying an N-terminal region sharing high identity with P. falciparum MSP7, as well as a similar proteolytical cleavage pattern. This protein's expression in P. vivax asexual blood stages was revealed by immuno-histochemical and molecular techniques. © 2006 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.bbrc.2006.10.082

DO - 10.1016/j.bbrc.2006.10.082

M3 - Research Article

C2 - 17081497

SN - 0006-291X

VL - 351

SP - 639

EP - 644

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 3

ER -

Cloning, expression, and characterisation of a Plasmodium vivax MSP7 family merozoite surface protein

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