Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo

Nadine Nsiangani Lusambo; Dieudonné Kaimbo Wa Kaimbo; Dieudonné Mumba Ngoyi; Janvier Kilangalanga Ngoy; Marie Thérèse Ngoyi Bambi; Théodore Kadima Mutombo; Guy Kintoki Makela; Lady Ngandowe Nzamokili; Alejandra de-la-Torre

doi:10.1080/09273948.2022.2140297

Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo

Nadine Nsiangani Lusambo
, Dieudonné Kaimbo Wa Kaimbo
, Dieudonné Mumba Ngoyi
, Janvier Kilangalanga Ngoy
, Marie Thérèse Ngoyi Bambi
, Théodore Kadima Mutombo
, Guy Kintoki Makela
, Lady Ngandowe Nzamokili
, Alejandra de-la-Torre

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

5 Citas (Scopus)

Resumen

PROPÓSITO: Describir datos demográficos, características clínicas y perfiles serológicos en una cohorte de pacientes congoleños con toxoplasmosis ocular (OT).

MÉTODO: Estudio transversal, realizado entre marzo de 2020 y julio de 2021 en dos clínicas oftalmológicas de Kinshasa.

RESULTADOS: El estudio incluyó 95 participantes con OT. Cincuenta y tres pacientes eran hombres (55,8%). La edad media de presentación fue de 35,6 ± 14,1 años (rango 8-69 años); 71 tenían OT activa (74,7%), entre ellos, 33 tenían OT primaria (46,5%), y 38 tenían recurrencias (53,5%). En el momento de la presentación, 51 pacientes (53,7%) presentaban deterioro visual (AV < 6/18). Las lesiones retinocoroideas se localizaban en la retina central en 60 pacientes (63,1%). Los pacientes con OT primaria tienden a tener niveles de IgG más altos que aquellos con OT recurrente ( P = .01).

CONCLUSIÓN: Informamos de la mayor cohorte de pacientes con OT en el África subsahariana. En nuestro entorno, la mayoría de los pacientes tenían OT recurrente con lesiones retinocoroideas múltiples, extensas y centrales.

Idioma original	Inglés estadounidense
Páginas (desde-hasta)	1-6
Número de páginas	6
Publicación	Ocular Immunology and Inflammation
Volumen	31
N.º	7
DOI	https://doi.org/10.1080/09273948.2022.2140297
Estado	Publicada - nov. 3 2022

Áreas temáticas de ASJC Scopus

Inmulogía y alergología
Oftalmología

ODS de las Naciones Unidas

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Nsiangani Lusambo, N., Kaimbo Wa Kaimbo, D., Mumba Ngoyi, D., Kilangalanga Ngoy, J., Ngoyi Bambi, M. T., Kadima Mutombo, T., Kintoki Makela, G., Ngandowe Nzamokili, L., & de-la-Torre, A. (2022). Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo. Ocular Immunology and Inflammation, 31(7), 1-6. https://doi.org/10.1080/09273948.2022.2140297

@article{9e8ba0e4bc7c4dacbf83baa338ed838b,

title = "Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo",

abstract = "PURPOSE: To describe demographic data, clinical features, and serological profiles in a cohort of Congolese patients with ocular toxoplasmosis (OT).METHOD: Cross-sectional study, carried out between March 2020 and July 2021 in two ophthalmic clinics in Kinshasa.RESULTS: The study comprised 95 participants with OT. Fifty-three patients were male (55.8\%). The mean age at presentation was 35.6 ± 14.1 years (range 8-69 years); 71 had active OT (74.7\%), among them, 33 had primary OT (46.5\%), and 38 had recurrences (53.5\%). At presentation, 51 patients (53.7\%) had visual impairment (VA < 6/18). Retinochoroidal lesions were located in the central retina in 60 patients (63.1\%). Patients with primary OT tend to have higher IgG levels than those with recurrent OT ( P = .01). CONCLUSION: We report the largest cohort of patients with OT in sub-Saharan Africa. In our setting, most patients had recurrent OT with multiple, extensive, and central retinochoroidal lesions.",

author = "\{Nsiangani Lusambo\}, Nadine and \{Kaimbo Wa Kaimbo\}, Dieudonn{\'e} and \{Mumba Ngoyi\}, Dieudonn{\'e} and \{Kilangalanga Ngoy\}, Janvier and \{Ngoyi Bambi\}, \{Marie Th{\'e}r{\`e}se\} and \{Kadima Mutombo\}, Th{\'e}odore and \{Kintoki Makela\}, Guy and \{Ngandowe Nzamokili\}, Lady and Alejandra de-la-Torre",

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year = "2022",

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day = "3",

doi = "10.1080/09273948.2022.2140297",

language = "English (US)",

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Nsiangani Lusambo, N, Kaimbo Wa Kaimbo, D, Mumba Ngoyi, D, Kilangalanga Ngoy, J, Ngoyi Bambi, MT, Kadima Mutombo, T, Kintoki Makela, G, Ngandowe Nzamokili, L & de-la-Torre, A 2022, 'Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo', Ocular Immunology and Inflammation, vol. 31, n.º 7, pp. 1-6. https://doi.org/10.1080/09273948.2022.2140297

Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo. / Nsiangani Lusambo, Nadine; Kaimbo Wa Kaimbo, Dieudonné; Mumba Ngoyi, Dieudonné et al.
En: Ocular Immunology and Inflammation, Vol. 31, N.º 7, 03.11.2022, p. 1-6.

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

TY - JOUR

T1 - Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo

AU - Nsiangani Lusambo, Nadine

AU - Kaimbo Wa Kaimbo, Dieudonné

AU - Mumba Ngoyi, Dieudonné

AU - Kilangalanga Ngoy, Janvier

AU - Ngoyi Bambi, Marie Thérèse

AU - Kadima Mutombo, Théodore

AU - Kintoki Makela, Guy

AU - Ngandowe Nzamokili, Lady

AU - de-la-Torre, Alejandra

PY - 2022/11/3

Y1 - 2022/11/3

N2 - PURPOSE: To describe demographic data, clinical features, and serological profiles in a cohort of Congolese patients with ocular toxoplasmosis (OT).METHOD: Cross-sectional study, carried out between March 2020 and July 2021 in two ophthalmic clinics in Kinshasa.RESULTS: The study comprised 95 participants with OT. Fifty-three patients were male (55.8%). The mean age at presentation was 35.6 ± 14.1 years (range 8-69 years); 71 had active OT (74.7%), among them, 33 had primary OT (46.5%), and 38 had recurrences (53.5%). At presentation, 51 patients (53.7%) had visual impairment (VA < 6/18). Retinochoroidal lesions were located in the central retina in 60 patients (63.1%). Patients with primary OT tend to have higher IgG levels than those with recurrent OT ( P = .01). CONCLUSION: We report the largest cohort of patients with OT in sub-Saharan Africa. In our setting, most patients had recurrent OT with multiple, extensive, and central retinochoroidal lesions.

AB - PURPOSE: To describe demographic data, clinical features, and serological profiles in a cohort of Congolese patients with ocular toxoplasmosis (OT).METHOD: Cross-sectional study, carried out between March 2020 and July 2021 in two ophthalmic clinics in Kinshasa.RESULTS: The study comprised 95 participants with OT. Fifty-three patients were male (55.8%). The mean age at presentation was 35.6 ± 14.1 years (range 8-69 years); 71 had active OT (74.7%), among them, 33 had primary OT (46.5%), and 38 had recurrences (53.5%). At presentation, 51 patients (53.7%) had visual impairment (VA < 6/18). Retinochoroidal lesions were located in the central retina in 60 patients (63.1%). Patients with primary OT tend to have higher IgG levels than those with recurrent OT ( P = .01). CONCLUSION: We report the largest cohort of patients with OT in sub-Saharan Africa. In our setting, most patients had recurrent OT with multiple, extensive, and central retinochoroidal lesions.

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U2 - 10.1080/09273948.2022.2140297

DO - 10.1080/09273948.2022.2140297

M3 - Research Article

C2 - 36328437

AN - SCOPUS:85141372517

SN - 0927-3948

VL - 31

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JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

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ER -

Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo

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