Chlamydia trachomatis Frequency in a Cohort of HPV-Infected Colombian Women

Edith Margarita Quinónez-Calvache, Dora Inés Ríos-Chaparro, Juan David Ramírez, Sara Cecilia Soto-De León, Milena Camargo, Luisa Del Río-Ospina, Ricardo Sánchez, Manuel Elkin Patarroyo, Manuel Alfonso Patarroyo

Resultado de la investigación: Contribución a RevistaArtículo

4 Citas (Scopus)

Resumen

BACKGROUND: Chlamydia trachomatis (C. trachomatis), an obligate intracellular bacterium, is the commonest infectious bacterial agent of sexual transmission throughout the world. It has been shown that the presence of this bacteria in the cervix represents a risk regarding HPV persistence and, thereafter, in developing cervical cancer (CC). Prevalence rates may vary from 2% to 17% in asymptomatic females, depending on the population being analysed. This study reports the identification of C. trachomatis in a cohort of 219 HPV-infected Colombian females.\n\nMETHODS: C. trachomatis infection frequency was determined during each of the study's follow-up visits; it was detected by amplifying the cryptic plasmid sequence by polymerase chain reaction (PCR) using two sets of primers: KL5/KL6 and KL1/KL2. Infection was defined as a positive PCR result using either set of primers at any time during the study. Cox proportional risk models were used for evaluating the association between the appearance of infection and a group of independent variables.\n\nRESULTS: Base line C. trachomatis infection frequency was 28% (n = 61). Most females infected by C. trachomatis were infected by multiple types of HPV (77.42%), greater prevalence occurring in females infected with HPV-16 (19.18%), followed by HPV-58 (17.81%). It was observed that females having had the most sexual partners (HR = 6.44: 1.59-26.05 95%CI) or infection with multiple types of HPV (HR = 2.85: 1.22-6.63 95%CI) had the greatest risk of developing C. trachomatis.\n\nCONCLUSIONS: The study provides data regarding the epidemiology of C. trachomatis /HPV coinfection in different population groups of Colombian females and contributes towards understanding the natural history of C. trachomatis infection.
Idioma originalEnglish (US)
Páginas (desde-hasta)e0147504
PublicaciónPLoS One
Volumen11
N.º1
DOI
EstadoPublished - ene 25 2016

Huella dactilar

Chlamydia trachomatis
Polymerase chain reaction
Bacteria
Chlamydia Infections
Epidemiology
infection
Human papillomavirus 16
Plasmids
Infection
polymerase chain reaction
Polymerase Chain Reaction
uterine cervical neoplasms
cervix
Sexual Partners
bacteria
Natural History
Coinfection
mixed infection
Population Groups
natural history

Citar esto

Quinónez-Calvache, E. M., Ríos-Chaparro, D. I., Ramírez, J. D., Soto-De León, S. C., Camargo, M., Del Río-Ospina, L., ... Patarroyo, M. A. (2016). Chlamydia trachomatis Frequency in a Cohort of HPV-Infected Colombian Women. PLoS One, 11(1), e0147504. https://doi.org/10.1371/journal.pone.0147504
Quinónez-Calvache, Edith Margarita ; Ríos-Chaparro, Dora Inés ; Ramírez, Juan David ; Soto-De León, Sara Cecilia ; Camargo, Milena ; Del Río-Ospina, Luisa ; Sánchez, Ricardo ; Patarroyo, Manuel Elkin ; Patarroyo, Manuel Alfonso. / Chlamydia trachomatis Frequency in a Cohort of HPV-Infected Colombian Women. En: PLoS One. 2016 ; Vol. 11, N.º 1. pp. e0147504.
@article{2d6bccb677474b1e87c4c7b5aa3ba97e,
title = "Chlamydia trachomatis Frequency in a Cohort of HPV-Infected Colombian Women",
abstract = "BACKGROUND: Chlamydia trachomatis (C. trachomatis), an obligate intracellular bacterium, is the commonest infectious bacterial agent of sexual transmission throughout the world. It has been shown that the presence of this bacteria in the cervix represents a risk regarding HPV persistence and, thereafter, in developing cervical cancer (CC). Prevalence rates may vary from 2{\%} to 17{\%} in asymptomatic females, depending on the population being analysed. This study reports the identification of C. trachomatis in a cohort of 219 HPV-infected Colombian females.\n\nMETHODS: C. trachomatis infection frequency was determined during each of the study's follow-up visits; it was detected by amplifying the cryptic plasmid sequence by polymerase chain reaction (PCR) using two sets of primers: KL5/KL6 and KL1/KL2. Infection was defined as a positive PCR result using either set of primers at any time during the study. Cox proportional risk models were used for evaluating the association between the appearance of infection and a group of independent variables.\n\nRESULTS: Base line C. trachomatis infection frequency was 28{\%} (n = 61). Most females infected by C. trachomatis were infected by multiple types of HPV (77.42{\%}), greater prevalence occurring in females infected with HPV-16 (19.18{\%}), followed by HPV-58 (17.81{\%}). It was observed that females having had the most sexual partners (HR = 6.44: 1.59-26.05 95{\%}CI) or infection with multiple types of HPV (HR = 2.85: 1.22-6.63 95{\%}CI) had the greatest risk of developing C. trachomatis.\n\nCONCLUSIONS: The study provides data regarding the epidemiology of C. trachomatis /HPV coinfection in different population groups of Colombian females and contributes towards understanding the natural history of C. trachomatis infection.",
author = "Quin{\'o}nez-Calvache, {Edith Margarita} and R{\'i}os-Chaparro, {Dora In{\'e}s} and Ram{\'i}rez, {Juan David} and {Soto-De Le{\'o}n}, {Sara Cecilia} and Milena Camargo and {Del R{\'i}o-Ospina}, Luisa and Ricardo S{\'a}nchez and Patarroyo, {Manuel Elkin} and Patarroyo, {Manuel Alfonso}",
year = "2016",
month = "1",
day = "25",
doi = "10.1371/journal.pone.0147504",
language = "English (US)",
volume = "11",
pages = "e0147504",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "1",

}

Quinónez-Calvache, EM, Ríos-Chaparro, DI, Ramírez, JD, Soto-De León, SC, Camargo, M, Del Río-Ospina, L, Sánchez, R, Patarroyo, ME & Patarroyo, MA 2016, 'Chlamydia trachomatis Frequency in a Cohort of HPV-Infected Colombian Women', PLoS One, vol. 11, n.º 1, pp. e0147504. https://doi.org/10.1371/journal.pone.0147504

Chlamydia trachomatis Frequency in a Cohort of HPV-Infected Colombian Women. / Quinónez-Calvache, Edith Margarita; Ríos-Chaparro, Dora Inés; Ramírez, Juan David; Soto-De León, Sara Cecilia; Camargo, Milena; Del Río-Ospina, Luisa; Sánchez, Ricardo; Patarroyo, Manuel Elkin; Patarroyo, Manuel Alfonso.

En: PLoS One, Vol. 11, N.º 1, 25.01.2016, p. e0147504.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Chlamydia trachomatis Frequency in a Cohort of HPV-Infected Colombian Women

AU - Quinónez-Calvache, Edith Margarita

AU - Ríos-Chaparro, Dora Inés

AU - Ramírez, Juan David

AU - Soto-De León, Sara Cecilia

AU - Camargo, Milena

AU - Del Río-Ospina, Luisa

AU - Sánchez, Ricardo

AU - Patarroyo, Manuel Elkin

AU - Patarroyo, Manuel Alfonso

PY - 2016/1/25

Y1 - 2016/1/25

N2 - BACKGROUND: Chlamydia trachomatis (C. trachomatis), an obligate intracellular bacterium, is the commonest infectious bacterial agent of sexual transmission throughout the world. It has been shown that the presence of this bacteria in the cervix represents a risk regarding HPV persistence and, thereafter, in developing cervical cancer (CC). Prevalence rates may vary from 2% to 17% in asymptomatic females, depending on the population being analysed. This study reports the identification of C. trachomatis in a cohort of 219 HPV-infected Colombian females.\n\nMETHODS: C. trachomatis infection frequency was determined during each of the study's follow-up visits; it was detected by amplifying the cryptic plasmid sequence by polymerase chain reaction (PCR) using two sets of primers: KL5/KL6 and KL1/KL2. Infection was defined as a positive PCR result using either set of primers at any time during the study. Cox proportional risk models were used for evaluating the association between the appearance of infection and a group of independent variables.\n\nRESULTS: Base line C. trachomatis infection frequency was 28% (n = 61). Most females infected by C. trachomatis were infected by multiple types of HPV (77.42%), greater prevalence occurring in females infected with HPV-16 (19.18%), followed by HPV-58 (17.81%). It was observed that females having had the most sexual partners (HR = 6.44: 1.59-26.05 95%CI) or infection with multiple types of HPV (HR = 2.85: 1.22-6.63 95%CI) had the greatest risk of developing C. trachomatis.\n\nCONCLUSIONS: The study provides data regarding the epidemiology of C. trachomatis /HPV coinfection in different population groups of Colombian females and contributes towards understanding the natural history of C. trachomatis infection.

AB - BACKGROUND: Chlamydia trachomatis (C. trachomatis), an obligate intracellular bacterium, is the commonest infectious bacterial agent of sexual transmission throughout the world. It has been shown that the presence of this bacteria in the cervix represents a risk regarding HPV persistence and, thereafter, in developing cervical cancer (CC). Prevalence rates may vary from 2% to 17% in asymptomatic females, depending on the population being analysed. This study reports the identification of C. trachomatis in a cohort of 219 HPV-infected Colombian females.\n\nMETHODS: C. trachomatis infection frequency was determined during each of the study's follow-up visits; it was detected by amplifying the cryptic plasmid sequence by polymerase chain reaction (PCR) using two sets of primers: KL5/KL6 and KL1/KL2. Infection was defined as a positive PCR result using either set of primers at any time during the study. Cox proportional risk models were used for evaluating the association between the appearance of infection and a group of independent variables.\n\nRESULTS: Base line C. trachomatis infection frequency was 28% (n = 61). Most females infected by C. trachomatis were infected by multiple types of HPV (77.42%), greater prevalence occurring in females infected with HPV-16 (19.18%), followed by HPV-58 (17.81%). It was observed that females having had the most sexual partners (HR = 6.44: 1.59-26.05 95%CI) or infection with multiple types of HPV (HR = 2.85: 1.22-6.63 95%CI) had the greatest risk of developing C. trachomatis.\n\nCONCLUSIONS: The study provides data regarding the epidemiology of C. trachomatis /HPV coinfection in different population groups of Colombian females and contributes towards understanding the natural history of C. trachomatis infection.

U2 - 10.1371/journal.pone.0147504

DO - 10.1371/journal.pone.0147504

M3 - Article

C2 - 26807957

VL - 11

SP - e0147504

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 1

ER -

Quinónez-Calvache EM, Ríos-Chaparro DI, Ramírez JD, Soto-De León SC, Camargo M, Del Río-Ospina L y otros. Chlamydia trachomatis Frequency in a Cohort of HPV-Infected Colombian Women. PLoS One. 2016 ene 25;11(1):e0147504. https://doi.org/10.1371/journal.pone.0147504