Characterization of adverse drug reactions causing admission to an intensive care unit

Camilo Rojas-Velandia, Jair Ruiz-Garzón, Juan Carlos Moscoso-Alcina, Álvaro Vallejos-Narvaéz, Jenny Castro-Canoa, Yuri Bustos-Martínez, Max Flórez-Cutiva, Mabel Contreras-Muñoz, Jully Carolina Gómez-Gil, Carlos Alberto Calderón-Ospina

Resultado de la investigación: Contribución a RevistaArtículo

3 Citas (Scopus)

Resumen

© 2017 The British Pharmacological Society.Aims: This study aimed to determine the occurrence of adverse drug reactions (ADRs) that caused admission to the intensive care unit (ICU) of a university hospital. Methods: Clinical records were reviewed for patients meeting the inclusion criteria who were admitted to the ICU between September and December 2012. Suspected cases of ADRs were documented. Nine researchers later evaluated causality using the Naranjo Algorithm, preventability using the Schumock and Thornton criteria, and clinical classification based on the dose-time-susceptibility system. Results: In total, 96 patients presented 108 cases of ADR (13.8%, 95% confidence interval 11.2-16.4%) as the cause of admission. The most frequent ADRs were bradyarrhythmias and upper gastrointestinal bleeding (12%). Therapeutic failure accounted for 20%. The most commonly associated medications were acetylsalicylic acid (16%) and losartan (10%). Forty-six cases were categorized as possible, and only one as definite. According to the dose-time-susceptibility classification, in 82% of the cases, the dosage was collateral (within the therapeutic range), and 90% were independent of time; the factors most associated with susceptibility to ADRs were comorbidities (42%) and age (49%). Forty-four percent of the ADRs were considered possibly preventable. Conclusions: ADRs contribute significantly to ICU admissions, and a significant number of ADRs are preventable. National studies are needed to assess their incidence and to establish classification standards to reduce their clinical impact.
Idioma originalEnglish (US)
PublicaciónBritish Journal of Clinical Pharmacology
DOI
EstadoPublished - ene 1 2017

Huella dactilar

Drug-Related Side Effects and Adverse Reactions
Intensive Care Units
Losartan
Bradycardia
Causality
Aspirin
Comorbidity
Research Personnel
Confidence Intervals
Hemorrhage
Incidence
Therapeutics

Citar esto

Rojas-Velandia, C., Ruiz-Garzón, J., Moscoso-Alcina, J. C., Vallejos-Narvaéz, Á., Castro-Canoa, J., Bustos-Martínez, Y., ... Calderón-Ospina, C. A. (2017). Characterization of adverse drug reactions causing admission to an intensive care unit. British Journal of Clinical Pharmacology. https://doi.org/10.1111/bcp.13199
Rojas-Velandia, Camilo ; Ruiz-Garzón, Jair ; Moscoso-Alcina, Juan Carlos ; Vallejos-Narvaéz, Álvaro ; Castro-Canoa, Jenny ; Bustos-Martínez, Yuri ; Flórez-Cutiva, Max ; Contreras-Muñoz, Mabel ; Gómez-Gil, Jully Carolina ; Calderón-Ospina, Carlos Alberto. / Characterization of adverse drug reactions causing admission to an intensive care unit. En: British Journal of Clinical Pharmacology. 2017.
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title = "Characterization of adverse drug reactions causing admission to an intensive care unit",
abstract = "{\circledC} 2017 The British Pharmacological Society.Aims: This study aimed to determine the occurrence of adverse drug reactions (ADRs) that caused admission to the intensive care unit (ICU) of a university hospital. Methods: Clinical records were reviewed for patients meeting the inclusion criteria who were admitted to the ICU between September and December 2012. Suspected cases of ADRs were documented. Nine researchers later evaluated causality using the Naranjo Algorithm, preventability using the Schumock and Thornton criteria, and clinical classification based on the dose-time-susceptibility system. Results: In total, 96 patients presented 108 cases of ADR (13.8{\%}, 95{\%} confidence interval 11.2-16.4{\%}) as the cause of admission. The most frequent ADRs were bradyarrhythmias and upper gastrointestinal bleeding (12{\%}). Therapeutic failure accounted for 20{\%}. The most commonly associated medications were acetylsalicylic acid (16{\%}) and losartan (10{\%}). Forty-six cases were categorized as possible, and only one as definite. According to the dose-time-susceptibility classification, in 82{\%} of the cases, the dosage was collateral (within the therapeutic range), and 90{\%} were independent of time; the factors most associated with susceptibility to ADRs were comorbidities (42{\%}) and age (49{\%}). Forty-four percent of the ADRs were considered possibly preventable. Conclusions: ADRs contribute significantly to ICU admissions, and a significant number of ADRs are preventable. National studies are needed to assess their incidence and to establish classification standards to reduce their clinical impact.",
author = "Camilo Rojas-Velandia and Jair Ruiz-Garz{\'o}n and Moscoso-Alcina, {Juan Carlos} and {\'A}lvaro Vallejos-Narva{\'e}z and Jenny Castro-Canoa and Yuri Bustos-Mart{\'i}nez and Max Fl{\'o}rez-Cutiva and Mabel Contreras-Mu{\~n}oz and G{\'o}mez-Gil, {Jully Carolina} and Calder{\'o}n-Ospina, {Carlos Alberto}",
year = "2017",
month = "1",
day = "1",
doi = "10.1111/bcp.13199",
language = "English (US)",
journal = "British Journal of Clinical Pharmacology",
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Rojas-Velandia, C, Ruiz-Garzón, J, Moscoso-Alcina, JC, Vallejos-Narvaéz, Á, Castro-Canoa, J, Bustos-Martínez, Y, Flórez-Cutiva, M, Contreras-Muñoz, M, Gómez-Gil, JC & Calderón-Ospina, CA 2017, 'Characterization of adverse drug reactions causing admission to an intensive care unit', British Journal of Clinical Pharmacology. https://doi.org/10.1111/bcp.13199

Characterization of adverse drug reactions causing admission to an intensive care unit. / Rojas-Velandia, Camilo; Ruiz-Garzón, Jair; Moscoso-Alcina, Juan Carlos; Vallejos-Narvaéz, Álvaro; Castro-Canoa, Jenny; Bustos-Martínez, Yuri; Flórez-Cutiva, Max; Contreras-Muñoz, Mabel; Gómez-Gil, Jully Carolina; Calderón-Ospina, Carlos Alberto.

En: British Journal of Clinical Pharmacology, 01.01.2017.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Characterization of adverse drug reactions causing admission to an intensive care unit

AU - Rojas-Velandia, Camilo

AU - Ruiz-Garzón, Jair

AU - Moscoso-Alcina, Juan Carlos

AU - Vallejos-Narvaéz, Álvaro

AU - Castro-Canoa, Jenny

AU - Bustos-Martínez, Yuri

AU - Flórez-Cutiva, Max

AU - Contreras-Muñoz, Mabel

AU - Gómez-Gil, Jully Carolina

AU - Calderón-Ospina, Carlos Alberto

PY - 2017/1/1

Y1 - 2017/1/1

N2 - © 2017 The British Pharmacological Society.Aims: This study aimed to determine the occurrence of adverse drug reactions (ADRs) that caused admission to the intensive care unit (ICU) of a university hospital. Methods: Clinical records were reviewed for patients meeting the inclusion criteria who were admitted to the ICU between September and December 2012. Suspected cases of ADRs were documented. Nine researchers later evaluated causality using the Naranjo Algorithm, preventability using the Schumock and Thornton criteria, and clinical classification based on the dose-time-susceptibility system. Results: In total, 96 patients presented 108 cases of ADR (13.8%, 95% confidence interval 11.2-16.4%) as the cause of admission. The most frequent ADRs were bradyarrhythmias and upper gastrointestinal bleeding (12%). Therapeutic failure accounted for 20%. The most commonly associated medications were acetylsalicylic acid (16%) and losartan (10%). Forty-six cases were categorized as possible, and only one as definite. According to the dose-time-susceptibility classification, in 82% of the cases, the dosage was collateral (within the therapeutic range), and 90% were independent of time; the factors most associated with susceptibility to ADRs were comorbidities (42%) and age (49%). Forty-four percent of the ADRs were considered possibly preventable. Conclusions: ADRs contribute significantly to ICU admissions, and a significant number of ADRs are preventable. National studies are needed to assess their incidence and to establish classification standards to reduce their clinical impact.

AB - © 2017 The British Pharmacological Society.Aims: This study aimed to determine the occurrence of adverse drug reactions (ADRs) that caused admission to the intensive care unit (ICU) of a university hospital. Methods: Clinical records were reviewed for patients meeting the inclusion criteria who were admitted to the ICU between September and December 2012. Suspected cases of ADRs were documented. Nine researchers later evaluated causality using the Naranjo Algorithm, preventability using the Schumock and Thornton criteria, and clinical classification based on the dose-time-susceptibility system. Results: In total, 96 patients presented 108 cases of ADR (13.8%, 95% confidence interval 11.2-16.4%) as the cause of admission. The most frequent ADRs were bradyarrhythmias and upper gastrointestinal bleeding (12%). Therapeutic failure accounted for 20%. The most commonly associated medications were acetylsalicylic acid (16%) and losartan (10%). Forty-six cases were categorized as possible, and only one as definite. According to the dose-time-susceptibility classification, in 82% of the cases, the dosage was collateral (within the therapeutic range), and 90% were independent of time; the factors most associated with susceptibility to ADRs were comorbidities (42%) and age (49%). Forty-four percent of the ADRs were considered possibly preventable. Conclusions: ADRs contribute significantly to ICU admissions, and a significant number of ADRs are preventable. National studies are needed to assess their incidence and to establish classification standards to reduce their clinical impact.

U2 - 10.1111/bcp.13199

DO - 10.1111/bcp.13199

M3 - Article

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

SN - 0306-5251

ER -

Rojas-Velandia C, Ruiz-Garzón J, Moscoso-Alcina JC, Vallejos-Narvaéz Á, Castro-Canoa J, Bustos-Martínez Y y otros. Characterization of adverse drug reactions causing admission to an intensive care unit. British Journal of Clinical Pharmacology. 2017 ene 1. https://doi.org/10.1111/bcp.13199